Clinical trials: Deglutition Disorder
GERD
A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects
A Study to compare pharmacokinetics and safety of CKD-381 and D026 in healthy male subjects
- Trial name
- NCT03444402
- Testing
- CKD-381(formulation I), CKD-381(formulation II), D026(Nexium 40mg)
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Nasogastric Feeding, Training Family Caregivers
Effectiveness of an Web Application in Enhancing Informal Caregivers' Nasogastric Tube Feeding Competency
The goal of this trial is to determine whether adding a nasogastric tube web application to standard face-to-face caregiver training helps informal caregivers learn nasogastric tube feeding more quickly than standard training…
- Conditions
- Nasogastric Feeding, Training Family Caregivers, Family Caregivers, Informal Caregiver
- Trial name
- NCT07414563
- Testing
- Nasogastric tube web application
- Where
- Singapore
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Dysphagia, Oral Phase, Temporomandibular Disorders
Efficacy of the Myofunctional Therapy on Oral Dysphagia
The aim of the study is to analyze the effects of orofacial myofunctional therapy (OMT) on oral dysphagia (OD) in patients with temporomandibular disorders (TMD).
- Trial name
- NCT04636606
- Testing
- Home Exercise, Manual Therapy Combined with Home Exercise, Orofacial Myofunctional Therapy combined with Manual Therapy and Home Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hasan Kalyoncu University
Disorders of Gut-brain Interaction, Lifestyle and Dietary Interventions
Comprehensive Management Strategies for Gastroesophageal Reflux Disease: A Study of Multidimensional Interventions and Health Impacts
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder, with around 80% of patients experiencing nighttime symptoms.
- Conditions
- Disorders of Gut-brain Interaction, Lifestyle and Dietary Interventions, Gastroesophageal Reflux Disease
- Trial name
- NCT07754721
- Testing
- Dietary intervention guided by a nutritionist, Written dietary education intervention
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- Hualien Tzu Chi General Hospital
Deglutition Disorders, Critical Illness
Swallowing Difficulties in ICU Patients [Synkebesvær Hos Intensivpatienter]
Swallow disorders or dysphagia related to mechanical ventilation affects between 1,300 and 2,000 patients in Danish intensive care units every year and increases aspiration, pneumonia and risk of dying.
- Trial name
- ICU-Swallow (NCT04428749)
- Testing
- Yale Swallow Protocol, FEES (fiberoptic endoscopic evaluation of swallowing)
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hospitalsenheden Vest
Cough, Gastroesophageal Reflux
Longitudinal Study of Children With a Chronic Cough and the Impact of Gastroesophageal Reflux
Cough is both an important physiologic component of lung defense and a cardinal indicator of disease. For those with chronic cough, defined as cough lasting for more than 3 weeks, the differential diagnosis is broad, including…
- Trial name
- NCT00771706
- Testing
- Proton Pump Inhibitor
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Gastroesophageal Reflux Disease
PK Study With Pantoprazole in Obese Children and Adolescents
Multicenter, comparative single-dose pharmacokinetic (PK) study
- Trial name
- PAN01 (NCT02186652)
- Testing
- Pantoprazole
- Where
- 4 sites in United States
- Volunteers
- 41 people
- Sponsor
- Phillip Brian Smith
Amyotrophic Lateral Sclerosis (ALS), Dysphagia
Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS
Prospective, single-arm pilot study evaluating transcutaneous electrical nerve stimulation of the superior laryngeal nerve (TENS-SLN) in individuals with ALS.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Dysphagia, Dystussia
- Trial name
- NCT07606235
- Testing
- Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow
- Volunteers
- 5 people
- Sponsor
- Nova Southeastern University
Gastrointestinal Subepithelial Tumors
The Prospective Study on the Effect of Ilaprazole in Non-erosive Reflux Disease Patients; Focused on Histologic Findings and Inflammatory Biomarker
Non-erosive reflux disease (NERD) patients used to be less responsive to proton pump inhibitor (PPI)s as compared with patients with erosive esophagitis.
- Trial name
- NCT02666976
- Testing
- Ilaprazole
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Gastroesophageal Reflux Disease, Obesity, Morbid
Determination of Change in Reflux Disease After Sleeve Gastrectomy by Intraluminal Impedance and pH-meter
710 / 5.000 Çeviri sonuçları Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric procedure in obesity. The overall relationship between sleeve gastrectomy and gastroesophageal reflux disease is still…
- Trial name
- NCT05405816
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Gastroesophageal Reflux
ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)
The purpose of this study is to evaluate the effect of ADX10059 in patients with gastroesophageal reflux disease who are partial responders to proton pump inhibitors
- Trial name
- NCT00810485
- Testing
- ADX10059
- Where
- 40 sites in United States, France and 3 more
- Volunteers
- 298 people
- Sponsor
- Addex Pharma S.A.
Cervical Disc Disease, Cervical Radiculopathy
Rehabilitation After Anterior Cervical Discectomy and Fusion
Anterior cervical discectomy and fusion (ACDF) is a commonly performed surgical procedure for cervical disc herniation, cervical radiculopathy, and degenerative cervical spine disorders.
- Conditions
- Cervical Disc Disease, Cervical Radiculopathy, Postoperative Dysphagia
- Trial name
- ACDF-REHAB (NCT07814950)
- Testing
- Structured Postoperative Rehabilitation Program, Standard Postoperative Follow-up
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
IBM, Inclusion Body Myositis
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
This study will evaluate whether neuromuscular ultrasound and MRI can be used as imaging markers of bulbar involvement and swallowing dysfunction in individuals with inclusion body myositis (IBM).
- Conditions
- IBM, Inclusion Body Myositis, Myopathy, Myositis
- Trial name
- NCT07823101
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dysphagia, Stroke
Fostering Eating After Stroke With Transcranial Direct Current Stimulation
Swallowing difficulties are common after a stroke and can lead to serious complications like pneumonia and malnutrition. Unfortunately, there are no effective treatment for improving swallowing in stroke patients.
- Trial name
- FEASt (NCT01919112)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Esophageal Stenosis, Deglutition Disorders
Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis
Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. There are some cases of strictures refractory to dilation sessions.
- Conditions
- Esophageal Stenosis, Deglutition Disorders, Head and Neck Neoplasms, Esophageal Neoplasms
- Trial name
- NCT03540953
- Testing
- Endoscopic injection of Mitomycin C
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Fauze Maluf Filho
Gastroesophageal Reflux
Treatment Of Gastroesophageal Reflux Disease By Endoscopic Fundoplication, A Placebo-Controlled Study
Aim: To evaluate the therapeutic efficacy of a therapeutic procedure, involving endoscopic suturing, for gastroesophageal reflux disease (GERD) compared to a sham procedure.
- Trial name
- NCT00235677
- Testing
- Endoscopic gastroplication
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Laryngopharyngeal Reflux
Prevacid vs Lifestyle Modifications for the Treatment of LPR
The purpose of this study is to evaluate changes in scores on the Reflux Finding Score and Reflux Symptom Index over a 24 week period.
- Trial name
- NCT00274339
- Testing
- Prevacid 30mg BID, Lifestyle changes of exercise and diet changes for weight loss and avoidance of reflux inducing foods.
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Hodge, Kenneth M., M.D.
Dysphagia, Healthy Aging
Swallowing Impairments in ICU Survivors and Community-Dwelling Adults
Post-intensive care syndrome (PICS), which consists of physical, cognitive, and psychosocial problems, is a pervasive complication for older intensive care unit (ICU) survivors and contributes to detrimental health outcomes and…
- Conditions
- Dysphagia, Healthy Aging, Post Intensive Care Syndrome, Caregiver Burden
- Trial name
- NCT07005037
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Sjögren's Syndrome, Xerostomia
The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome
Sjögren's syndrome (SS) is a chronic, systemic and autoimmune disease characterized by inflammation, fibrosis and dysfunction of exocrine glands such as tear and salivary glands.
- Conditions
- Sjögren's Syndrome, Xerostomia, Dysphagia, Salivary Flow Rate
- Trial name
- SS (NCT05680064)
- Testing
- Tongue, lip, chin exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Saglik Bilimleri Universitesi
Gastro Esophageal Reflux
Efficacy Of Hiatal Closure For GERD
The purpose of this protocol is to study the efficacy of hiatal closure for early GERD disease. The study team hypothesizes that hiatal closure for early GERD disease is an efficacious treatment of GERD.
- Trial name
- NCT06280664
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
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