Clinical trials: Delayed Graft Function
Delayed Graft Function, End Stage Renal Disease
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients.
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Kidney Transplantation
- Trial name
- NCT06367205
- Testing
- Goal-Directed Fluid Therapy (GDFT), Regular Fluid Therapy
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- RenJi Hospital
End Stage Renal Disease, Reperfusion Injury
Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function
The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplantation.
- Conditions
- End Stage Renal Disease, Reperfusion Injury, Delayed Graft Function, Kidney Transplantation
- Trial name
- KTX (NCT02568696)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Deceased Donor Kidney Transplantation, Living Donor Kidney Transplantation
Adequate Definition of Delayed Graft Function in Living and Deceased Donor Kidney Transplantation
It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict…
- Trial name
- NCT02080117
- Testing
- kidney transplantation, living or deceased donor
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Delayed Graft Function, Other Complications of Kidney Transplant
Biomarkers of Aging as Predictors of Kidney Transplant Function
The primary purpose of this study is to measure the correlation between baseline expression of aging biomarkers, SenesceTest in blood of organ donor and renal graft function.
- Trial name
- NCT02335333
- Testing
- No treatment
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sapere Bio
Kidney Transplantation
ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF
The primary objective of the following randomized open label trial is to demonstrate how low immunological risk patients (no anti HLA immunization and first kidney transplantation) but diagnosed at high-risk of delayed graft…
- Trial name
- PREDICT-DGF (NCT02056938)
- Testing
- Anti-Thymocyte Globulins treatment, Basiliximab treatment
- Where
- 4 sites in France
- Volunteers
- 19 people
- Sponsor
- Nantes University Hospital
Kidney Transplantation, Graft Rejection
A Study on a New Staining Method (C4d Staining) of Transplanted Kidney Biopsies
Patients who had received kidney transplantation may suffer from rejection. Recently, positive staining for C4d in kidney biopsies of malfunctioning transplant kidney is increasingly recognized as an important prognostic…
- Trial name
- NCT00498095
- Testing
- Renal biopsy
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Hospital Authority, Hong Kong
Kidney Transplantation
Contrast-Enhanced Ultrasound for Kidney Transplant
Contrast-enhanced ultrasound (CEUS) is a promising non-invasive imaging tool that may aid in the early detection of kidney transplant complications, such as delayed graft function (DGF) and acute allograft rejection.
- Trial name
- NCT02911714
- Testing
- Lumason Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
End Stage Renal Disease, Kidney Failure
C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI
The use of C1INH (Berinert) in patients receiving deceased donor kidney transplants with high risk for delayed graft function (DGF) may show significant improvement in outcomes post transplant compared with patients that do not…
- Conditions
- End Stage Renal Disease, Kidney Failure, Delayed Graft Function, Ischemic Reperfusion Injury
- Trial name
- C1INHDGF (NCT02134314)
- Testing
- C1 Esterase Inhibitor
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Cedars-Sinai Medical Center
Delayed Graft Function, Acute Graft Rejection
Comparison of Sirolimus and Azathioprine in Lung Transplantation
The purpose of this study is to compare the safety and effectiveness of two different anti-rejection drug regimens.
- Trial name
- NCT00321906
- Testing
- azathioprine, sirolimus
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Chicago
Renal Transplant
A Study of the Correlation Between Donor UDP-Glc and Transplanted Kidney Function
Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), however, organ shortage is the primary bottleneck restricting the progression of organ transplantation.1 Organs from Expanded Criteria Donors…
- Trial name
- NCT06707272
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qianghua Leng
Delayed Graft Function
Propensity Score Matched Comparison of HMP vs. SCS in Kidney Transplantation
Hypothermic machine perfusion (HMP) is considered superior to static cold storage (SCS) in kidney transplantation, but the true benefit in the real-world experience remains incompletely understood.
- Trial name
- HMP (NCT04359173)
- Where
- Austria
- Volunteers
- 347 people
- Sponsor
- Medical University Innsbruck
Delayed Graft Function
Role of T Helper 17 and Regulatory T Cells in Delayed Graft Function
Delayed graft function (DGF) increases risk of acute rejection after kidney transplantation (KTx). Interleukin-6, which is produced in DGF, is critical in directing naive T helper cells differentiation towards T helper 17 (Th17)…
- Trial name
- NCT01232816
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Kidney Transplantation, Delayed Graft Function
Context - Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Function
The purpose of this study is to determine whether remote ischemic conditioning can improve the outcome after renal transplantation with deceased donor.
- Conditions
- Kidney Transplantation, Delayed Graft Function, Acute Kidney Injury, Glomerular Filtration Rate
- Trial name
- Context (NCT01395719)
- Testing
- Remote ischemic conditioning
- Where
- 4 sites in Denmark, Netherlands and 1 more
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Delayed Graft Function
Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant
Delayed graft function occurs in more than 20% of kidney transplantations. It is an episode of post-ischemic acute kidney injury with long-term consequences on the allograft's function.
- Trial name
- GABRIEL (NCT05513807)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Graft-Versus-Host Disease(GVHD), Anemia Due to Disturbance of Proliferation and/or Differentiation of Hematopoietic Stem Cells
CliniMACS® CD34+ Reagent System for Expanded Access Use
CliniMACs is an investigational device used to select and enrich stem cells. The device will select the stem cells with CD34+ protein.
- Conditions
- Graft-Versus-Host Disease(GVHD), Anemia Due to Disturbance of Proliferation and/or Differentiation of Hematopoietic Stem Cells, Graft Failure, Delayed Graft Function
- Trial name
- NCT02026934
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joseph Antin
Delayed Graft Function, End Stage Renal Disease
Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation
A Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Deceased Donor Kidney Transplant
- Trial name
- NCT07020832
- Testing
- Pegcetacoplan
- Where
- Brazil
- Sponsor
- Apellis Pharmaceuticals, Inc.
Delayed Function of Renal Transplant
A Study on SANGUINATE™ for the Reduction of Delayed Graft Function in Kidney Transplant Patients
Safety and efficacy study of SANGUINATE on reduction of delayed graft function (DGF) in patients who will be recipients of a donation after brain death (DBD) donor kidney.
- Trial name
- NCT02658162
- Testing
- SANGUINATE, Normal Saline
- Sponsor
- Prolong Pharmaceuticals
Delayed Graft Function, Kidney Transplant; Complications
The Frequency and Risk Factors of Delayed Graft Function
Delayed graft function (DGF) is an important phenomenon after kidney transplantation with direct and indirect implication on graft survival.
- Trial name
- NCT03555513
- Testing
- living kidney transplantation
- Volunteers
- 500 people
- Sponsor
- nooshin dalili
Ischemia Reperfusion Injury, Delayed Graft Function
Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation
The objectives of this study are to test the preliminary safety and efficacy of a two-day peri-operative course of treprostinil in reducing ischemia-reperfusion injury in adult patients receiving a deceased donor kidney…
- Trial name
- NCT04005469
- Testing
- Treprostinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rhode Island Hospital
Delayed Graft Function
YSPSL for Prevention of Delayed Graft Function Part A
Selectins have been implicated in the pathogenesis of ischemia/reperfusion (I/R)-induced kidney injury and resultant DGF. PSGL-1 is a ligand for P-, E-, and L-selectin.
- Trial name
- NCT00298181
- Testing
- YSPSL
- Where
- 10 sites in United States
- Volunteers
- 15 people
- Sponsor
- Y's Therapeutics, Inc.