Clinical trials: Delirium, completed
Emergence Delirium
Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children
Study where children will receive one premedication, either intranasal dexmedetomidine or oral midazolam, to reduce agitation on emergence of anesthesia.
- Trial name
- NCT03171740
- Testing
- Dexmedetomidine, Midazolam oral solution, Oral saline
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Brasilia University Hospital
Emergence Delirium, Anesthesia Emergence Delirium
Effect of Monochromatic Light on Incidence of Emergence Delirium in Children
Emergence delirium/emergence agitation (ED/EA) is a behavioral phenomenon of unclear etiology consisting of short lived behavioral changes that can be both traumatic to families and pose a safety risk to patients and staff.
- Trial name
- NCT03285243
- Testing
- Monochromatic blue light
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Delirium, Critical Illness
Delirium Screening 3 Methods Study
Observational study comparing three different methods of delirium detection in critically ill patients.
- Trial name
- DELIS-3 (NCT04551508)
- Where
- 14 sites in Denmark
- Volunteers
- 1,126 people
- Sponsor
- Hospitalsenheden Vest
Delirium
Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients
The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.
- Trial name
- NCT02548923
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Postoperative Delirium (POD)
The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study
Glucocorticoids can be used to inhibit postoperative systemic inflammatory response syndrome. They may reduce the risk of major complications and mortality.
- Trial name
- NCT07271394
- Testing
- Administration of methylprednisolone sodium succinate during general anesthesia induction, No administration of methylprednisolone sodium succinate during general anesthesia induction
- Where
- China
- Volunteers
- 25,800 people
- Sponsor
- Chinese PLA General Hospital
Delirium
Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium
180 patients will be randomly divided into two groups 90 patients each using a computer-generated program. Group R: 90 patients will receive a Rivastigmine patch (4.6 mg) 24 h before the operation to 3 days post-operative Group…
- Trial name
- NCT04189666
- Testing
- Rivastigmine Transdermal System [Exelon], Melatonin
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Critical Illness, Delirium
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study
This proof-of-concept study examines whether the acute brain dysfunction that occurs in critically ill patients is improved by administration of intravenous guanfacine.
- Conditions
- Critical Illness, Delirium, Cognitive Impairment
- Trial name
- MENDING (NCT04742673)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt University Medical Center
Delirium Superimposed on Dementia
Delirium in Persons With Dementia
The aims of this study were to identify risk factors associated with delirium in hospitalized persons with dementia, and to describe immediate and post-hospital (1\&3 months) trajectory of cognitive decline and associated…
- Trial name
- NCT01394328
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- Penn State University
Delirium, Congenital Heart Disease
An Intervention to Reduce Delirium After Cardiac Surgery
Patients that have cardiac surgery may suffer from unrecognized cerebral ischemia or loss of blood flow to the brain temporarily during surgery.
- Conditions
- Delirium, Congenital Heart Disease, Coronary Artery Disease, Heart Valve Disease
- Trial name
- NCT02587039
- Testing
- Remote ischemic pre-conditioning, Delirium Assessment
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Johns Hopkins University
Emergence Delirium
Preoperative Chronotype and Emergence Delirium in the Elderly
Emergence delirium (ED) is a prevalent and severe postoperative complication in elderly surgical patients. It can occur at any perioperative stage but most frequently develops during or immediately after emergence from general…
- Trial name
- NCT07722481
- Testing
- the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
- Where
- China
- Volunteers
- 235 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Delirium
Prediction of PACU Delirium Using EEG - German Validation Study
Aim of this observational study is to investigate whether frontal electroencephalogram analysis is able to predict increased risk for PACU delirium.
- Trial name
- PACUD-EEG (NCT03287401)
- Testing
- Electroencephalography
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Delirium in Old Age, Delirium of Mixed Origin
Music Therapy as a Treatment for Delirium in Acutely Hospitalized Older Patients
The purpose of this study is to assess feasibility and potential effectiveness of two different music interventions for managing delirium symptoms in acute geriatric patients.
- Conditions
- Delirium in Old Age, Delirium of Mixed Origin, Delirium Superimposed on Dementia, Delirium Confusional State
- Trial name
- NCT05398211
- Testing
- Preferred Recorded Music (PRM), Preferred Live Music (PLM)
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Delirium, Intensive Care Unit, Randomised Controlled Trial
The Effects of a Model-based Sensory Stimulation Intervention on Preventing Delirium Among Intensive Care Unit Patients: A Randomised Controlled Trial
Delirium is highly associated with adverse clinical outcomes of intensive care unit (ICU) patients, including increased cognitive impairment, duration of intubation, ICU length of stay, mortality, physical dependence, and health…
- Trial name
- NCT04306016
- Testing
- Sensory stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Chinese University of Hong Kong
Adult Patients, Intensive Care Unit
Functional Recovery Over the First Year After ICU Discharge
Intensive Care Unit Acquired Delirium (ICU-AD) and Intensive Care Unit Acquired Weakness (ICU-AW) are common in critically ill, mechanically ventilated adult patients.
- Trial name
- NCT04206306
- Where
- Taiwan
- Volunteers
- 407 people
- Sponsor
- National Taiwan University Hospital
Postoperative Delirium, Transcranial Magnetic Stimulation, Repetitive
Continuous Theta Burst Stimulation (cTBS) and Postoperative Delirium
To investigate the impact of cTBS on the incidence of postoperative delirium and changes of cognitive function in elderly patients after surgery.
- Trial name
- NCT04661904
- Testing
- Continuous theta burst stimulation (cTBS)
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Shanghai 10th People's Hospital
C.Surgical Procedure; Cardiac, Acute Kidney Injury
Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery
The purpose of this study is to evaluate the possible association between portal vein flow pulsatility and acute kidney injury after cardiac surgery.
- Conditions
- C.Surgical Procedure; Cardiac, Acute Kidney Injury, Postoperative Complications, Right-Sided Heart Failure
- Trial name
- PP-AKI (NCT02831907)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- Montreal Heart Institute
Delirium
Physical Restraint of Critically Ill Patients
Background: Physical restraint of patients in the intensive care unit (ICU) is a common practice, with estimated prevalence of 50% of all ICU patients, with and without invasive ventilation support(1).
- Trial name
- NCT04771793
- Testing
- new physical restraint protocols
- Where
- Israel
- Volunteers
- 992 people
- Sponsor
- Meir Medical Center
Postoperative Vomiting, Postoperative Nausea
Sugammadex and Neostigmine in Pediatric Patients
In this study, it was aimed to compare the use of sugammadex instead of neostigmine + atropine in the reversal of NMB in children undergoing lower abdominal surgery or urogenital surgery, and to compare the rates of postoperative…
- Conditions
- Postoperative Vomiting, Postoperative Nausea, Postoperative Delirium
- Trial name
- NCT05618236
- Testing
- Group N; neostigmine+atropine, GROUP S; decurarized with sugammadex.
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Marmara University
Elderly (People Aged 65 or More), Hip Fracture
The Role of Precision Anesthesia Strategy on Perioperative Organ Protection in Hip Surgery [PASPOP]
The goal of this clinical trial is to investigate the effect of three anesthetic strategies on organ protection in elderly patients undergoing hip fracture surgery.
- Conditions
- Elderly (People Aged 65 or More), Hip Fracture, Delirium - Postoperative, Organ Protection
- Trial name
- PASPOP (NCT06696404)
- Testing
- Combined Lumbar Plexus and Sacral Plexus Block, iliac fascial block, spinal anesthesia
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Delirium, Cognition Disorders
The MIND Study: Modifying the INcidence of Delirium
Delirium is associated with increased risk of death, prolonged stay, higher cost of care, and likely long-term brain deficits in survivors.
- Trial name
- NCT00096863
- Testing
- Ziprasidone, Haloperidol
- Where
- 5 sites in United States
- Volunteers
- 102 people
- Sponsor
- Vanderbilt University