Clinical trials: Delirium, completed
Dementia, Delirium
Pharmacokinetic Study Comparing Topical, Rectal, and Oral Quetiapine
Quetiapine, a second generation antipsychotic, is only available as oral tablets. However, topical and rectal formulations have been produced in compounding pharmacies.
- Trial name
- NCT02131545
- Testing
- Quetiapine 25 mg gel applied topically, Quetiapine 25 mg tablet by mouth, Quetiapine 25 mg rectal suppository
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postoperative Nausea and Vomiting, Post Operative Pain
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children
this study will aim to evaluate the effects of dexmedetomidine, dexamethasone and Ondansetron on the prevention of postoperative nausea and vomiting in children undergoing dental rehabilitation surgery.
- Conditions
- Postoperative Nausea and Vomiting, Post Operative Pain, Emergence Delirium
- Trial name
- NCT05124067
- Testing
- Dexamethasone, Ondansetron, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tanta University
Delirium
Feasibility of an App to Measure Patient Stressors in an Intensive Care Unit (ICU Feel Better App)- a Before-and-after Study
This study examines the feasibility and efficacy of a mobile application (app), which enables critically ill patients to report perceived patient stressors to their caregivers.
- Trial name
- NCT04880967
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Hip Fractures
Deep Neuromuscular Block on Cytokines Release and Postoperative Delirium
The purpose of the study is to determine the relationship between the degree of neuromuscular block, the release of cytokines and clinical outcomes in elderly patients undergoing orthopedic surgery.
- Trial name
- NCT02507609
- Testing
- Moderate neuromuscular blockade, Deep neuromuscular blockade
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Konkuk University Medical Center
Delirium, Critical Illness
Light and Noise: Objectively Assessing Environmental Risk Factors for Delirium in the ICU
Recognition of delirium as a medical entity with relevance to both morbidity and mortality, especially in critically ill patients, is a relatively recent development.
- Trial name
- LANYARD-ICU (NCT06294158)
- Testing
- Brightness measurement, Sound level measurement
- Where
- Austria
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Emergence Delirium, Anxiety Preoperative
Comparative Study Between Nebulised Dexmedetomidine and Nebulised Midazolam in Children Undergoing Lower Abdominal Surgeries
Comparative study between nebulised dexmedetomidine and nebulized midazolam in reducing preoperative anxiety and emergence delirium in children undergoing lower abdominal surgeries
- Trial name
- NCT05872087
- Testing
- Nebulised Dexmeditomidine, Nebulised Midazolam
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Orthopedics
Intraoperative Sedation and Postoperative Delirium
Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality.
- Trial name
- NCT02573558
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 855 people
- Sponsor
- Seoul National University Bundang Hospital
Delirium
Effect of Auditory Stimulation by Family Voices in Preventing Delirium: A Randomized Controlled Trial
Delirium is an acute cerebral dysfunction syndrome characterized by acute fluctuating changes in consciousness, cognitive dysfunction, and disorientation.
- Trial name
- NCT05732584
- Testing
- structured family voice stimulation, unstructured family voice stimulation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Delirium, Aging
A Trial to Reduce Delirium in Aged Post Acute Patients
The purpose of this study is to develop a comprehensive Delirium Abatement Program of care of delirious patients in the post acute care setting and to evaluate its impact on persistence and severity of delirium and on functional…
- Trial name
- NCT00182936
- Testing
- Delirium Abatement Program
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute on Aging (NIA)
Hip Fractures, Delirium
Post-Operative Delirium in Elderly Surgical Patients
This research is being done to see what effects sedative drugs during surgery have on peoples' thinking processes after they wake up.
- Trial name
- STRIDE (NCT00590707)
- Testing
- Deeper sedation, Moderate sedation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Delirium
Clinical Investigation of an Eye-Tracking Device as a Predictor of Delirium in the Recovery Room After Surgery With General Anesthesia
Neurotrack™ is an FDA-approved device for measuring and tracking cognitive decline, as may occur with age-related cognitive decline and Alzheimer's disease.
- Trial name
- NCT05579093
- Testing
- Cognitive test + Pupillary measure
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Columbia University
Delirium, Depression
Incidence and Predictors of Delirium After Cardiac Surgery
The objective of the present research is to evaluate the incidence and independent predictors of delirium observed among patients after cardiac surgery.
- Conditions
- Delirium, Depression, Cognitive Impairment
- Trial name
- IPDACS (NCT00784576)
- Where
- Poland
- Volunteers
- 563 people
- Sponsor
- Medical University of Lodz
Cerebrovascular Circulation
NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery
Postoperative neurocognitive disorders (NCD) are of high priority in perioperative management. The risk of suffering from NCD after surgery may be increased due to perioperative impairment of cerebrovascular autoregulation and…
- Trial name
- SONICA (NCT04978558)
- Testing
- Continuous assessment of cerebrovascular autoregulation with NIRS and TCD
- Where
- Germany
- Volunteers
- 509 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Dementia, Depression
3D Team Care for Cognitively Vulnerable Older Adults
This study addresses how to achieve better outcomes for cognitively vulnerable community-dwelling older adults and their families.
- Conditions
- Dementia, Depression, Delirium
- Trial name
- NCT02945085
- Testing
- Home Based Care Team, Telephone Based Care Team
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- UConn Health
Rebound Pain Impact After Hip Surgery With Nerve Block
Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly.
- Trial name
- NCT07295184
- Testing
- Peripheral nerve block applied, Only multimodal analgesia applied
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konya City Hospital
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Delirium
Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults
(From NIH reporter) Each year >16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory…
- Trial name
- INTUIT (NCT03273335)
- Testing
- Millipore biomarker assay plate
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Postoperative Delirium (POD), Thoracoscopic Surgery
Comparative Effects of Remimazolam Tosylate and Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery.
Postoperative delirium (POD) is a common acute brain dysfunction in the perioperative period, characterized by acute fluctuations in attention, consciousness, and cognition, typically occurring early after surgery.
- Conditions
- Postoperative Delirium (POD), Thoracoscopic Surgery, Dexmedetomidine, Remimazolam Besylate
- Trial name
- NCT07569614
- Testing
- Dexmedetomidine, Remimazolam Besylate, Normal Saline
- Where
- China
- Volunteers
- 105 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Anesthesia Emergence Delirium
Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair
Emergence Delirium And Recovery Profile In Patients Undergoing Cleft Lip And Cleft Palate Repair With Either Combination Of Morphine Plus Fentanyl Or Fentanyl Alone
- Trial name
- NCT03010540
- Testing
- MORPHINE PLUS FENTANYL, Fentanyl
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Delirium, Sleep Disorders, Circadian Rhythm
Study of Sleep and Delirium in the Intensive Care Unit (ICU)
The investigators will perform a prospective, cohort study of 100 older intensive care unit (ICU) patients, to investigate the association between sleep disruption and ICU delirium.
- Trial name
- SID (NCT01280097)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco