Clinical trials: Delirium
Ophthalmology
Study on the Effect of Eye-covering Pretreatment on Acute Delirium After General Anesthesia in Pre-school Aged Children
Participants (preschool children), because their cognitive ability and anti pressure ability are obviously weaker than adults, most of the children who have this kind of operation and anesthesia stressors will have perioperative…
- Trial name
- NCT04973150
- Testing
- To explore whether pretreatment with eye covering can reduce the incidence of acute delirium and the score of delirium after general anesthesia in ophthalmology pre-age children.
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Delirium (POD), Frailty at Older Adults
Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients
Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Lymphocyte
- Trial name
- NCT07322744
- Where
- China
- Volunteers
- 6,475 people
- Sponsor
- Chinese PLA General Hospital
Cardiac Surgical Procedures
Low Dose Dexmedetomidine and Delirium After Cardiac Surgery
Delirium after cardiac surgery can occur in up to 50% of the patients and has been shown to be significantly associated with increased morbidity and mortality. Advanced age is a significant risk factor of delirium.
- Trial name
- LOWDEXDEL (NCT03388541)
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 420 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Implementation Science, Delirium
Determinants of Implementation Success Coordinating Ventilator, Early Ambulation and Rehabilitation Efforts
There is a fundamental gap between the discovery of proven-effective intensive care unit (ICU) sedation, mechanical ventilation, mobility, and symptom management strategies and approaches that can equip ICU providers with the…
- Conditions
- Implementation Science, Delirium, Intensive Care Unit Acquired Weakness, Pain
- Trial name
- DISCOVER-ICU (NCT04249141)
- Testing
- Survey and concept mapping
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Delirium
Delirium in the (Neuro)Intensive/Critical Care in the Adult and Paediatric Czech Populations
Intensive and critical care in the intensive care unit (ICU) is often associated with ICU delirium and post-ICU dementia, regardless of the nature of the primary disease or insult.
- Trial name
- NCT05891873
- Testing
- CAM-ICU, ICDSC, 4AT
- Where
- Czechia
- Volunteers
- 700 people
- Sponsor
- Masaryk University
Perioperative Cardiavascular Complication, Peroperative Complication
Perioperative Management of Risk Factors in the Elderly Patients
In 2017, the number of operations on hospitalized patients in China was more than 57 million, of which more than 20 million were performed on elderly patients (≥65 years of age).
- Conditions
- Perioperative Cardiavascular Complication, Peroperative Complication, Perioperative Pulmonary Complication, Perioperative Neurological Complication
- Trial name
- NCT04967872
- Testing
- Implementing risk management and control plan for the elderly during perioperative period
- Where
- China
- Volunteers
- 4,782 people
- Sponsor
- Ailin Luo
Delirium Risk, Critical Illness in Coronary ICU Patients
THE EFFECTS OF VIRTUAL ART THERAPY ON PHYSIOLOGICAL PARAMETERS, DELIRIUM RISK, ANGER, ANXIETY, AND MENTAL AND SPIRITUAL RECOVERY IN INTENSIVE CARE PATIENTS.
Patients in intensive care units experience significant physiological and psychological stress due to life-threatening conditions and invasive treatments.
- Conditions
- Delirium Risk, Critical Illness in Coronary ICU Patients, Mental and Spiritual Recovery, Effects of Virtual Art Therapy
- Trial name
- NCT07562802
- Testing
- Virtual Art Therapy
- Volunteers
- 62 people
- Sponsor
- Inonu University
Anxiety, Preoperative Care
A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation
Proper preoperative sedation can reduce patients' anxiety, enhance patients' cooperation and reduce perioperative complications.
- Conditions
- Anxiety, Preoperative Care, Pharmacokinetics, Emergence Delirium
- Trial name
- NCT03800641
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Postoperative Delirium (POD) After Nephrectomy
A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic Nephrectomy
A prospective comparative clinical trial of postoperative delirium incidence in open versus laparoscopic nephrectomy
- Trial name
- NCT07892898
- Testing
- Open Nephrectomy, Laparoscopic Nephrectomy
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Postoperative Delirium
Biomarkers and Postoperative Delirium in Elderly Patients
This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method…
- Trial name
- NCT05454228
- Testing
- postoperative delirium
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Provincial People's Hospital
Valvular Surgery
Relationship Between Postoperative Delirium and Heart Function in Valvular Surgery
Delirium is an acute brain lesion characterized by abnormalities of consciousness, attention, cognition and sensation. Many brain diseases such as stroke, traumatic brain injury and intracranial hypertension can lead to cardiac…
- Trial name
- NCT05211934
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Anzhen Hospital
Foramen Ovale, Patent, Delirium
Patent Foramen Ovale and the Risk of Postoperative Delirium Following Elective Hip and Knee Arthroplasty Surgeries
This study will involve patients who are planned to have hip or knee replacement surgeries. They will undergo a Transthoracic Echocardiogram study (an ultrasound of the heart) to look for a Patent Foramen Ovale (PFO).
- Conditions
- Foramen Ovale, Patent, Delirium, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT02400892
- Testing
- TTE Bubble Study
- Where
- Canada
- Volunteers
- 226 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Delirium, Diagnosis, Psychiatric
Validation Study of the Malay Version of 3D-CAM
Validation of the Malay version of 3D-CAM, involving two-staged process. 1. Translation and cultural adaptation of 3D-CAM into the Malay language. 2.
- Trial name
- VS-MEDCAM (NCT03366896)
- Testing
- Malay 3D-CAM diagnostic tool 1, Malay 3D-CAM Diagnostic tool 2
- Volunteers
- 110 people
- Sponsor
- University of Malaya
Delirium in Old Age, Sleep Disturbance
Sleep & Postoperative Delirium in Hispanic/ Latino Patients After Cardiothoracic Surgery
The purpose of this research is to study pre-operative sleep problems and delirium in Hispanic/Latino patients after heart and lung surgery.
- Conditions
- Delirium in Old Age, Sleep Disturbance, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04786899
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
COVID-19
Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational Study
The purpose of this study is to determine the prevalence of brainstem dysfunction in critically ill ventilated and deeply sedated patients hospitalized in the Intensive Care Unit (ICU) for a SARS-CoV-s2 infection.
- Trial name
- BRAINSTEM-COV (NCT04527198)
- Testing
- Brainstem Responses Assessment Sedation Score (BRASS), Electroencephalogram with EKG lead
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Delirium
Longitudinal Cohort Study - for the Treatment of Acute Postoperative Pain and Postoperative Delirium, Postoperative Cognitive Dysfunctions, and Chronic Pain.
Adequate pain therapy is important aspect of perioperative care. Sequelae of inadequate pain management are patient dissatisfaction, post-operative nausea and vomiting (PONV), inadequate nutrition, lack of mobilization, and an…
- Conditions
- Pain, Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT03133858
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Delirium
Delirium in the Emergency Department: Novel Screening
Delirium is an acute confusional state characterized by altered or fluctuating mental status, inattention, and either disorganized thinking or an altered level of consciousness.
- Trial name
- NCT01162343
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Delirium, Postoperative Cognitive Dysfunction
Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery
Postoperative neurocognitive impairments often occur in elderly patients undergoing anesthesia and non-cardiac surgery, including postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Trial name
- NCT04341844
- Testing
- Methylene Blue
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Fudan University
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06861998
- Testing
- Message-based bedtime routine, sleep hygiene education
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Yan Fuxia
Postoperative Delirium
Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults
This research project is an observational cohort study by retrospective chart review of patients that underwent major noncardiac surgery at University Hospital Basel, Switzerland, in the years 2011-2015.
- Trial name
- PODMAS (NCT04460716)
- Testing
- Major noncardiac surgery
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland