Clinical trials: Delirium in the Intensive Care Unit
Delirium
Effectiveness and Safety of a Flexible Family Visitation Model for Delirium Prevention in Adult Intensive Care Units: a Cluster-randomized, Crossover Trial (The ICU Visits Study)
A cluster-randomized crossover trial involving adult ICU patients, family members, and ICU professionals will be conducted. Forty medical-surgical Brazilian ICUs with visiting hours <4.5 h/day will be randomly assigned to either…
- Trial name
- NCT02932358
- Testing
- Flexible Family Visitation Model (FFVM), Restrictive Family Visitation Model (RFVM)
- Where
- 33 sites in Brazil
- Volunteers
- 1,650 people
- Sponsor
- Hospital Moinhos de Vento
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Delirium
Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation
The primary aim of the DahLIA trial is to determine, in patients with ICU-associated delirium and agitation who are otherwise pathophysiologically stable (as defined), the number of ventilator-free hours in the incident ICU…
- Trial name
- DahLIA (NCT01151865)
- Testing
- Dexmedetomidine
- Where
- 7 sites in Australia
- Volunteers
- 96 people
- Sponsor
- Austin Health
Critical Illness, Intensive Care Unit Delirium
Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study
This BRAIN-ICU-2 study [Bringing to light the Risk factors And Incidence of Neuropsychological dysfunction (dementia) in ICU Survivors, 2nd Study] is in direct response to PAR-17-038 and will determine ICU patients' main paths to…
- Trial name
- BRAIN-2 (NCT04305600)
- Where
- 2 sites in United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Intensive Care Unit Delirium
PRE-DELIRIC Prediction Model Plus SMART Care to Reduce the Incidence of Delirium in ICU Patients
Delirium is a severe acute brain dysfunction characterised by sudden confusion, inattention and fluctuating level of consciousness, which mainly affects intubated intensive care patients.
- Trial name
- NCT06279390
- Where
- Taiwan
- Volunteers
- 381 people
- Sponsor
- National Taiwan University Hospital
Delirium
Reducing Delirium in the Surgical Intensive Care Unit
Delirium is an acute disturbance in mental abilities and confusion that affects many patient in the hospital and is caused by multiple factors including and altered sleep/wake cycles and multiple sedating medications.
- Trial name
- NCT02856737
- Testing
- eye masks and earplugs
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Intensive Care Unit Delirium
Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
- Trial name
- NCT05849597
- Testing
- Dexmedetomidine, Propofol
- Where
- Serbia
- Volunteers
- 200 people
- Sponsor
- University of Novi Sad
Patients in ICU, Delirium in the Intensive Care Unit
A Prospective Observational Study Using the FAM-CAM
The goal of this observational study is to learn whether family members can help identify signs of delirium in adult patients who are staying in the intensive care unit.
- Conditions
- Patients in ICU, Delirium in the Intensive Care Unit, Family
- Trial name
- NCT07694687
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium, Sleep
Investigation of Sleep in the Intensive Care Unit
Sleep deprivation is common and often severe in critically ill patients cared for in intensive care units (ICUs) and is hypothesized to be a modifiable risk factor for delirium, which in turn is hypothesized to be a modifiable…
- Trial name
- ICU-SLEEP (NCT03355053)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 522 people
- Sponsor
- Massachusetts General Hospital
Delirium, Critical Illness
Haloperidol for Delirium in Adult Critically Ill Patients
The EuRIDICE trial will study whether haloperidol as a first line treatment for ICU delirium reduces delirium duration (and severity).
- Conditions
- Delirium, Critical Illness, Intensive Care Psychosis, Cognitive Impairment
- Trial name
- EuRIDICE (NCT03628391)
- Testing
- Haloperidol
- Where
- 8 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- Erasmus Medical Center
Immersive Virtual Reality, Discomfort
Effect of a Virtual Reality Program on Patient Comfort in the Surgical Intensive Care Unit
Admission to a surgical intensive care unit (ICU) following major surgery is associated with a number of discomforts, not only related to the disease itself, but also to the care provided or the ICU environment itself (lights…
- Conditions
- Immersive Virtual Reality, Discomfort, IPREA, Intensive Care Unit
- Trial name
- ZION (NCT06830369)
- Testing
- HypnoVR, usual health care
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Delirium
Prevention of Delirium With Light in the Intensive Care Unit
The purpose of this multicenter randomised controlled trial is to investigate if circadian light at the patients bedside (using Philips HealWell system, CE marked)significantly reduces prevalence of delirium in mechanically…
- Trial name
- PreDeLight-ICU (NCT01727375)
- Testing
- Circadian light
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Mechanical Ventilation, Sedation
Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use
The purpose of the study is to develop and implement an evidence-based analgesia-sedation algorithm in the pediatric intensive care unit (PICU) using quality improvement and implementation science methodology.
- Trial name
- NCT04263662
- Testing
- Analgesia-Sedation algorithm
- Where
- United States
- Volunteers
- 680 people
- Sponsor
- Boston Children's Hospital
Critical Illness, Sleep Disturbance
Mobilisation in the EveNing to TreAt Delirium
Patients with severe illness require lifesaving treatment in intensive care units. Around a third of patients admitted to intensive care develop delirium. This is a severe state of confusion.
- Conditions
- Critical Illness, Sleep Disturbance, Mobility Limitation, Intensive Care Unit Delirium
- Trial name
- MENTAL (NCT05401461)
- Testing
- Evening mobilisation
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
ICU Delirium
Constructing a Model of Pupillary Parameters in Predicting Delirium Among Critically Ill Patients in the Intensive Unit
Delirium is commonly observed in critically ill patients in intensive care units (ICUs), imposing significant burdens on both patients and the healthcare system. Existing assessment tools have certain limitations.
- Trial name
- NCT06187792
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Delirium
The Impact of Nursing Delirium Preventive Interventions in the Intensive Care Unit
Delirium is a common disorder in Intensive Care Unit (ICU) patients and is associated with serious short- and long-term consequences.
- Trial name
- UNDERPIN-ICU (NCT03002701)
- Testing
- UNDERPIN-ICU program
- Where
- 11 sites in Netherlands
- Volunteers
- 1,750 people
- Sponsor
- Radboud University Medical Center
Intensive Care Unit Delirium, Delirium
The Effectiveness of Acupuncture for Delirium in Critically Ill Patients
Introduction: Intensive care unit (ICU) delirium is an acute onset of brain dysfunction, which can affect 25-80% of ICU patients.
- Conditions
- Intensive Care Unit Delirium, Delirium, Agitation
- Trial name
- NCT04312893
- Testing
- Acupuncture (Press Tack Needle)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Sleep Deprivation, Delirium
Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU
The purpose of this study is to analyze a multi-component sleep/wake protocol for optimization of environmental factors (noise, light, nursing activities) as well as non-environmental factors (pain, mechanical support devices…
- Trial name
- NCT03313115
- Testing
- Sleep/Wake Protocol
- Where
- United States
- Volunteers
- 685 people
- Sponsor
- University of Utah
Delirium, Sedation
Neurosteer Bedside Monitoring System
The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients.
- Conditions
- Delirium, Sedation, Agitation
- Trial name
- NCT06718764
- Testing
- Neurosteer's single-channel EEG monitoring device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai