Clinical trials: Delivery, Obstetric
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sepsis, Length of Stay
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis…
- Conditions
- Sepsis, Length of Stay, Mortality, Neurodevelopmental Delay
- Trial name
- LET-FEED (NCT06893939)
- Testing
- Limited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
- Where
- 6 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Washington
Prematurity
Effect of Osteopathic Manipulative Treatment on Pain in Preterms
Osteopathic manipulative treatment (OMT) has been used to treat term and preterm newborns. Recent studies demonstrated the effectiveness of OMT in reducing length of stay and costs (Cerritelli, 2013) as well as the likelihood of…
- Trial name
- NCT02146677
- Testing
- Osteopathic manipulative treatment, Usual care
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
PreTerm Birth
Physical Examination-Indicated Pessary
Cervical insufficiency, previously referred to as cervical incompetence, has classically been defined as painless dilation of the cervix in the absence of contractions or bleeding in the second trimester resulting in recurrent…
- Trial name
- NCT02967445
- Testing
- Arabin Pessary, Cervical cerclage
- Where
- Italy
- Sponsor
- Federico II University
Labor Pain
Intermittent Automated Devices for Labor Analgesia in Emilia Romagna
The study aims to determine whether the use of automated intermittent devices for labor analgesia could prevent the increase of instrumental deliveries, with same analgesia.
- Trial name
- PA-RER (NCT02710877)
- Testing
- Programmed Intermittent bolus, Manual epidural bolus, Levobupivacaine
- Where
- 3 sites in Italy
- Volunteers
- 671 people
- Sponsor
- University of Modena and Reggio Emilia
Premature Birth
Use of a Tummy Time Intervention and Parent Education in Infants Born Preterm
The purpose of this research study is to see if tummy time and parent education helps motor development among infants born preterm. Participants will be recruited from Ann and Robert H.
- Trial name
- NCT03759119
- Testing
- Tummy time and parent education, Parent education only
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Indianapolis
Preterm Birth
Preterm Birth and Long Term Consequences on Myocardial Functions and Structure
Cardiovascular diseases (hypertension, coronary heart disease, stroke and cardiac insufficiency) are the leading cause of death worldwide. They are a major cause of concern in public health worldwide as well.
- Trial name
- PREMACOEUR (NCT03589365)
- Testing
- Magnetic resonance imaging (MRI)
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Malnutrition
Dose Comparison of Amino Acids on Growth in Premature Neonates
Malnutrition is a common problem in the neonatal intensive care unit. Recent studies indicate that prematurely born neonates commonly develop a severe nutritional deficit during the first weeks after birth, referred to as…
- Trial name
- NCT00120926
- Testing
- Parenteral Nutrition
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Pediatrix
Preeclampsia
Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis
This clinical investigation is a medical device trial to examine the safety and efficacy of TheraSorb sFlt-1 adsorber treatment of pregnant patients with preeclampsia.
- Trial name
- SAVE (NCT02923206)
- Testing
- TheraSorb sFlt-1 adsorber
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Miltenyi Biomedicine GmbH
Pregnancy, Prematurity
Clindamycin to Reduce Preterm Birth in a Low Resource Setting
Preterm birth has been linked to certain types of vaginal infections. The goal of this study is to determine if giving women pregnant between 13-20 weeks with an elavated vaginal pH(evidence of this type of infection)Oral…
- Conditions
- Pregnancy, Prematurity, Preterm Birth, Bacterial Vaginosis
- Trial name
- NCT01800825
- Testing
- Clindamycin
- Where
- India
- Volunteers
- 1,726 people
- Sponsor
- Christiana Care Health Services
Preterm Birth
Evaluation of a Novel Diagnostic Kit for the Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth in Women Presenting With Signs and Symptoms of Preterm Labor
Currently, the American College of Obstetricians and Gynecologists (ACOG) indicate in their most recent Practice Bulletin on the Management of Preterm Labor that many tests to identify women at risk of preterm birth have been…
- Trial name
- PartoSure (NCT05742997)
- Testing
- PartoSure, Fetal Fibronectine
- Where
- Belgium
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Infant, Premature
The Comparison of Gentle Human Touch's Effect by Mother and Nurse on Pain Level During Heel Blood Sampling in Preterm Infants
This study is an experimental randomized controlled study conducted to compare the effect of gentle human touch applied by mother and nurse on pain level during heel blood sampling in preterm infant.
- Trial name
- NCT05857423
- Testing
- Gentle Human Touch
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
RDS of Prematurity, Prematurity
Fast Assessment of Surfactant Deficiency to Speed up Treatment
The aim is to validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) in terms of safety, usability, and efficacy.
- Trial name
- FAST (NCT03235882)
- Testing
- LS-ratio
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Blood Loss, Surgical, Blood Loss, Postoperative
Tranexamic Acid Versus Misoprostol to Reduce Blood Loss During and After Cesarean Section
Brief Summary The goal of this clinical trial is to compare two medicines, intravenous tranexamic acid and rectal misoprostol, for reducing blood loss in women undergoing cesarean section.
- Conditions
- Blood Loss, Surgical, Blood Loss, Postoperative, Cesarean Section
- Trial name
- NCT07712510
- Testing
- Intravenous Tranexamic Acid, rectal misoprostol
- Where
- Pakistan
- Volunteers
- 214 people
- Sponsor
- Medicare Hospital (Pvt) Limited
Preterm Labor
PoC Study of OBE022 in Threatened Preterm Labour
This is a proof-of-concept study in 2 parts. In Part A, patients will receive OBE022 open-label in order to assess the safety and pharmacokinetics in pregnant women with spontaneous preterm labour with a gestational age between…
- Trial name
- PROLONG (NCT03369262)
- Testing
- OBE022, Atosiban
- Where
- 18 sites in Czechia, Finland and 4 more
- Volunteers
- 115 people
- Sponsor
- ObsEva SA
Infant Development, Neonatal Intensive Care Unit
Individual Structured Therapy in Early Premature Infants at the Neonatal Intensive Care Unit
In this study, investigators aimed to apply an individual structured therapy protocol within the framework of neurodevelopmental therapy principles in early premature infants hospitalized in the neonatal intensive care unit and…
- Conditions
- Infant Development, Neonatal Intensive Care Unit, INDIVIDUALIZED THERAPY
- Trial name
- NCT06648213
- Testing
- Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Development
Neurodevelopmental Outcomes of Preterm Infants Treated for Pain Management With Repeated Doses of Sucrose 24%
The purpose of this study is to determine the effect of sucrose 24% for pain prevention on preterm infants. Our hypothesis is that repeated doses of sucrose 24%, given prior to painful procedure,do not impair neurodevelopmental…
- Trial name
- NCT01742520
- Testing
- multiple doses of sucrose, Formula or breast milk
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Vitamin d Deficiency, Preeclampsia
25- Hydroxyvitamin D Levels in Pregnancy and Effects on Pregnancy Related Disorders
Evaluation of 25- Hydroxyvitamin D levels in pregnant women in Austria and potential related disorders Hypothesis: Austrian pregnant women are Vitamin D deficient Present vitamin D supplementation in pregnancy is insufficient…
- Conditions
- Vitamin d Deficiency, Preeclampsia, Preterm Delivery, Gestational Hypertension
- Trial name
- VIDIS (NCT04637880)
- Where
- Austria
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Premature Infants
Kangaroo Care an EffectonTransitionTime From Gavage Feeding
Objectives: Kangaroo care is a safe and effective alternative method to conventional neonatal care for newborn babies. The aim of this study was to evaluate the effect of kangaroo care on the transition time to full oral feeding…
- Trial name
- KangarooCare (NCT05492747)
- Testing
- Kangaroo Care an Effect
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Firat University
Chlamydia Trachomatis Infection, Neonatal Infection
Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences
To assess the effectiveness of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) testing and treatment during pregnancy to reduce adverse pregnancy and birth outcomes compared to the standard of care (treatment based on…
- Conditions
- Chlamydia Trachomatis Infection, Neonatal Infection, Preterm Birth, Gonorrhea
- Trial name
- NCT04955717
- Testing
- Chlamydia trachomatis and Neisseria gonorrhoeae screening using the GeneXpert
- Where
- 2 sites in United States, Botswana
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Southern California