Clinical trials: Delivery Systems
Allergic Rhinitis
Single Dose Pharmacokinetics of Intranasal Azelastine Delivered by a Fixed Combination With Fluticasone in Comparison to Azelastine Nasal Sprays
The primary objective is to assess the effect of fluticasone propionate (FLU) on the relative bioavailability (AUC0-∞) of azelastine hydrochloride (AZE) when administered as fixed AZE-FLU combination product (TEST) compared to a…
- Trial name
- NCT01190852
- Testing
- Azelastine, Fluticasone, Azelastine mono, Azelastine
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MEDA Pharma GmbH & Co. KG
Premature Birth, NEC
Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit
Infections, particularly on the gastrointestinal tract, has been known to be one of the leading causes of death in preterm infants. This is due to the immaturity of the intestinal epithelial cells.
- Trial name
- NCT04004091
- Testing
- Spermine
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- dr. Riana Pauline Tamba, SpB(K)BA
Dementia
Delivery Models of Caregiver Support and Education
The proposed study seeks to compare usual care and two different interventions for caregivers (CGs) of Veterans with dementia that are brief and administered by telephone.
- Trial name
- NCT02368132
- Testing
- Group Delivered TEP, Individual Delivered TEP
- Where
- 2 sites in United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Contraception
KYleena Satisfaction Study / Observational Study on User Satisfaction With the Levonorgestrel Intrauterine Delivery System Kyleena (LNG-IUS 12) in New Contraceptive Users and After Switching From Another Contraceptive Method
The main goal of this non-interventional study (NIS) is to evaluate user satisfaction with Kyleena in a real-life setting and to identify factors which influence user satisfaction, taking into account previously used…
- Trial name
- KYSS (NCT03182140)
- Testing
- Kyleena
- Where
- 19 sites in United States, Belgium and 6 more
- Volunteers
- 1,134 people, healthy volunteers welcome
- Sponsor
- Bayer
Hiv
Estamos Juntos (We Are Together): Improving HIV Care Delivery by Capacitating Health Care Providers
Health care workers' negative behavior towards patients (likely a reflection of low job satisfaction, frustration with delivering HIV care and treatment in extremely resource-limited settings, and burnout) is one of the primary…
- Trial name
- NCT05938621
- Testing
- behavioral therapy and education
- Where
- Mozambique
- Volunteers
- 28,448 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Intestinal Perforation, Necrotizing Enterocolitis
IRT in Infants With Intestinal Perforation
This study is designed to evaluate a novel tool to aid in the diagnosis of intestinal perforation in infants who are at high risk.
- Trial name
- NCT01530828
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Sexually Transmitted Infection, HIV/AIDS
Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)
This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes.
- Conditions
- Sexually Transmitted Infection, HIV/AIDS, Cost-effectiveness, Birth Outcomes
- Trial name
- NCT04446611
- Testing
- First antenatal care + test-of-cure, First antenatal care + week 30-34 gestation (no test-of-cure)
- Where
- South Africa
- Volunteers
- 2,247 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Spinal Cord Injury
Biomechanics of Wheelchair Transfers
This is a laboratory-based study to evaluate the risk of shoulder injury associated with transfers between wheelchair and vehicle in persons with spinal cord injury.
- Trial name
- NCT00645567
- Testing
- Unassisted Manual Transfer, Standard Transfer Board, Glide n' Go
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
HIV Infections
Voluntary HIV Counseling, Testing, and Medication for Pregnant Women to Prevent Mother-to-Child HIV Transmission
Voluntary HIV counseling and testing (VCT) and anti-HIV drugs for pregnant women and their newborns decrease rates of mother-to-child transmission (MTCT) of HIV.
- Trial name
- NCT00084045
- Testing
- Intrapartum HIV counseling/testing, Postpartum HIV counseling/testing
- Where
- 2 sites in South Africa
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uterine Bleeding Profile Prediction
A Study to Learn More About How a Smartphone App Called MyIUS Predicts Future Menstrual Bleeding in Women After They Have Begun Using Intrauterine Birth Control Method (a Birth Control Device is Inserted Into a Woman's Uterus by Her Doctor)
Researchers are looking to learn more about future menstrual bleeding in women who have started using intrauterine contraception methods.
- Trial name
- MyIUS (NCT04989595)
- Testing
- MyIUS app
- Where
- 6 sites in Brazil, Denmark and 4 more
- Volunteers
- 3,045 people, healthy volunteers welcome
- Sponsor
- Bayer
Vomiting, Nausea
Exteriorized Versus In Situ Uterine Repair at Cesarean Delivery
This study was undertaken to compare the two techniques (exteriorized vs in situ) of uterine repair with respect to patient comfort, hemodynamic changes, surgical time and blood loss, in patients undergoing elective CD under a…
- Conditions
- Vomiting, Nausea, Pain, Hypotension
- Trial name
- NCT00452972
- Testing
- Spinal Anesthesia
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pre - Delivery Pregnant Women, Chronic Pain
Assessment of Central Pain in the Peripartum Period
Chronic pain is common. Up to 10% of the Population has been estimated to suffer from chronic pain and up to 5% of the female population has been estimated to suffer from widespread, chronic pain and tenderness, thus fulfilling…
- Conditions
- Pre - Delivery Pregnant Women, Chronic Pain, Pain During Delivery
- Trial name
- NCT01291680
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Polycystic Ovary Syndrome
Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age
The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age.
- Trial name
- SHK002 (NCT03905941)
- Testing
- Metformin, Oral combined hormonal contraceptives
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Insomnia
CBT-I Chatbot for Youth
Insomnia is prevalent in youth, and it associates with depression and other psychiatric disorders, leading to increased mental health burden.
- Trial name
- NCT05769231
- Testing
- Cognitive Behavioral Therapy for Insomnia in Chatbot
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Neural Tube Defects, Congenital Abnormalities
Birth Outcomes In Eswatini After Transition To Dolutegravir-Based Treatment
The goal of this observational study is to assess the birth outcomes of HIV-positive women delivering in hospitals in Eswatini who are receiving dolutegravir (DTG) or other anti-retroviral (ARV) drug regimens.
- Conditions
- Neural Tube Defects, Congenital Abnormalities, Teratogens
- Trial name
- NCT05883761
- Where
- 5 sites in Eswatini
- Volunteers
- 50,075 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Premature Birth, Bronchopulmonary Dysplasia
Assessment of Lung Structure and Function of Infants Born Prematurely
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Premature Birth, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00422305
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Indiana University
Preterm, Assessment
GMA and Peri in Moderate-late Preterms
To analyze the relationship between the early diagnosis of cerebral palsy with the risk factors of this pathology in moderate and late premature infants
- Conditions
- Preterm, Assessment, Risk Factor, Cerebral Palsy
- Trial name
- NCT04073836
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Hyperglycemia, Pregnancy
The Extension of HAPO Follow-up Study
The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease.
- Conditions
- Hyperglycemia, Pregnancy, Overnutrition, Maternal Obesity During Childbirth
- Trial name
- NCT05477511
- Where
- Hong Kong
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong