Clinical trials: Delivery Systems
HIV Infections, Mental Disorders
Psychiatric Problems in Children and Adolescents Infected With HIV at Birth
The purpose of this study is to determine whether HIV and anti-HIV drugs cause mental health problems or make mental health problems worse in children and adolescents who were infected with HIV at birth.
- Trial name
- NCT00100542
- Testing
- Psychiatric interviews
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Pain, Cesarean Section
Intrathecal Hydromorphone for Pain Control After Cesarean Section
The use of intrathecal opioids for analgesia in the setting of cesarean section has become standard obstetric anesthesia practice. Currently, two opioids are commonly used. These opioids are fentanyl and morphine (Duramorph).
- Trial name
- NCT02096003
- Testing
- Intrathecal morphine, Intrathecal hydromorphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Asthma, Healthy Subjects or Volunteers
A Study of Tralokinumab When Delivered Subcutaneously at Different Flow Rates to Healthy Volunteers
The primary objective of this study is to evaluate the pharmacokinetics (PK) and tolerability of tralokinumab when delivered subcutaneously at different flow rates to healthy volunteers.
- Trial name
- NCT02085473
- Testing
- Tralokinumab 300 mg
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Maternal Health, Infant Health
Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
The goal of this cluster randomized controlled trial is to study the effect of a mobile-phone based application used by pregnant women on maternal and newborn health indicators.
- Conditions
- Maternal Health, Infant Health, Institutional Delivery, Birth Preparedness and Complication Readiness
- Trial name
- CITH (NCT05697822)
- Testing
- Mobile Phone and Cloud-based Electronic Contact and Recording System
- Where
- Nepal
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Amit Arjyal
HIV Infections
Effectiveness of Communication Technology in Disseminating HIV Prevention Training to Non-governmental Organizations
This study will compare the effectiveness of face-to-face training versus Web-based training seminars in disseminating HIV prevention interventions to nongovernmental organizations in Eastern Europe and Central Asia.
- Trial name
- NCT00698529
- Testing
- Face-to-face training, Distance training, Popular Opinion Leader (POL)
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Feeding; Difficult, Newborn, Growth Failure
Prophylactic Probiotics to Extremely Low Birth Weight Prematures
Mortality and incidence of severe complications is still high among extremely premature infants. Common causes of severe complications in this population are poor nutrition, necrotizing enterocolitis, and severe infections.
- Conditions
- Feeding; Difficult, Newborn, Growth Failure, Necrotizing Enterocolitis, Sepsis
- Trial name
- PROPEL (NCT01603368)
- Testing
- Lactobacillus reuteri
- Where
- 2 sites in Sweden
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Analgesia, Epidural, Instrumental Delivery
The Randomised Epidural Analgesia in Term Delivering Women Trial (TREAT)
The objective of the study: to assess the impact of a proactive policy of offering EA at the start of labour as compared to a restrictive policy or care as usual.
- Conditions
- Analgesia, Epidural, Instrumental Delivery, Maternal Outcome, Neonatal Outcome
- Trial name
- TREAT (NCT01261689)
- Testing
- Ropivacaine/ Sufentanil according to local hospital protocol, Care-as usual pain treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bioavailability
Comparative Study Menaquinone-7
The objective of this study is to investigate the absorption of menaquinone-7 from a nutrient-enriched dairy product compared to a general dairy product enriched with menaquinone-7 and a menaquinone-7-containing supplement.
- Trial name
- NCT01873274
- Testing
- MK-7 containing capsule, basic yogurt enriched with MK-7, nutrient-enriched yogurt with MK-7
- Where
- Netherlands
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HIV Infections
Evaluating the Safety of and Immune Response to HIV-MAG DNA Vaccine With or Without Plasmid IL-12 Adjuvant Delivered Intramuscularly Via Electroporation Followed by VSV-gag HIV Vaccine Boost in Healthy, HIV-Uninfected Adults
Some vaccines may work better when given together with another substance known as an adjuvant or when given with an experimental procedure called electroporation (EP).
- Trial name
- NCT01578889
- Testing
- HIV-MAG vaccine, IL-12 pDNA adjuvant, VSV HIV gag vaccine
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ovarian Cancer
Salpingectomy at Cesarean Delivery for Ovarian Cancer Reduction (SCORE)
To compare the feasibility and surgical outcomes between complete salpingectomy and standard postpartum tubal ligation (partial salpingectomy) at the time of cesarean delivery in women with undesired future fertility.
- Trial name
- SCORE (NCT02374827)
- Testing
- Standard postpartum tubal ligation, Complete Salpingectomy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Sleep Quality, Premature Labor
Music Therapy in the Threat of Premature Birth
The scope of the study covers the effects of music therapy on risk perception levels and sleep quality in pregnant women hospitalized due to the diagnosis of premature birth threat.
- Conditions
- Sleep Quality, Premature Labor, Risk-Taking
- Trial name
- NCT05602883
- Testing
- music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sakarya University
HIV Infections
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
A new approach to HIV prevention currently being studied includes the use of topical microbicides, substances that kill microbes.
- Trial name
- NCT00540605
- Testing
- Tenofovir 1% vaginal gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain
Effect of Intracervical on the Pain Associated With the Insertion of the LNG-IUS
This study has the objective to evaluate the effect of Injectable intracervical anesthesia in comparison with a non-steroidal anti-inflammatory drug (NSAID) on the pain scores immediately after insertion of the…
- Trial name
- NCT02155166
- Testing
- Intracervical anesthesia with lidocaine 2%, ibuprofen 400 mg
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
HIV Infection, Tuberculosis
Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV
Tuberculosis (TB) is highly endemic in sub-Saharan Africa. The increased burden of TB in settings with high prevalence of the Human Immunodeficiency Virus (HIV) is associated with high rates of transmission of Mycobacterium…
- Conditions
- HIV Infection, Tuberculosis, Pneumocystis Jiroveci Pneumonia
- Trial name
- NCT00080119
- Testing
- Isoniazid (INH), Trimethoprim/Sulfamethoxazole (TMP/SMX)
- Where
- 6 sites in Botswana, South Africa
- Volunteers
- 1,354 people, healthy volunteers welcome
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Smoking
Nicotine Pharmacokinetic and Pharmacodynamics Profile, Safety and Tolerability of P3L
The purpose of this study is to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD, i.e., subjective effects) profiles, and the safety and tolerability of the nicotine-containing aerosol delivered by Platform 3 Liquid…
- Trial name
- NCT02532374
- Testing
- Nicorette® inhalator, P3L
- Where
- New Zealand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Parkinson Disease
Effects of Action Observation Training and Motor Imagery Delivered by Telerehabilitation in Patients with Parkinson's Disease
The goal of this clinical trial is to investigate the efficacy on motor and postural tasks of Action Observation Training (AOT) and Action Observation combined with Motor Imagery (AOMI) delivered by telerehabilitation in patients…
- Trial name
- TeleAOTPD (NCT06814782)
- Testing
- Action Observation Training, Action Observation and Motor Imagery, Exercise
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Insomnia, Anxiety
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
Transdiagnostic Internet-delivered Cognitive Behaviour Therapy (ICBT) is an efficacious treatment option for anxiety and depression; however, not all patients benefit equally and some leave treatment before program completion.
- Conditions
- Insomnia, Anxiety, Depression
- Trial name
- NCT04512768
- Testing
- Transdiagnostic Internet-delivered Cognitive Behaviour Therapy, Brief Internet-Delivered Cognitive Behaviour Therapy for Insomnia
- Where
- Canada
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Regina
Smoking, Smoking Cessation
Preference-based Tools for Smoking Cessation Among Disadvantaged Smokers, a Pragmatic Randomised Controlled Trial
Objective: Our study aims to evaluate the effectiveness of the "STOP" (Sevrage Tabagique à l'aide d'Outils dédiés selon la Préférence: Smoking Cessation using preference-based tools) intervention, a preference-based smoking…
- Trial name
- STOP (NCT04654585)
- Testing
- The STOP intervention, Standard Care
- Where
- 15 sites in France
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Société de Formation Thérapeutique du Généraliste - Recherche
Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders
The diabEAT Study: Insulin dElivery Technologies And eaTing Behaviours in People With Type 1 Diabetes
Type 1 diabetes is an autoimmune health condition that requires daily injections of insulin. Insulin allows the body to use energy from carbohydrates in food.
- Conditions
- Insulin Dependent Diabetes Mellitus, Feeding and Eating Disorders, Eating Behavior, Type 1 Diabetes
- Trial name
- NCT07348432
- Testing
- Automated Insulin Delivery (AID) Systems, Carbohydrate Counting Inaccuracy Percentage
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- McGill University