Clinical trials: Delivery Systems
Hepatic Malignant Neoplasm Primary Non-Resectable
Registry Protocol- Melphalan Percutaneous Hepatic Perfusion for the Treatment of Unresectable Hepatic Malignancy
Collection of Safety, Efficacy and Resource Utilization Information in Patients Who Have Received Melphalan PHP with the Delcath Hepatic Delivery System for the Treatment of Unresectable Hepatic Malignancy
- Trial name
- NCT03266042
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Delcath Systems Inc.
Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis
Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth
This study will only include infants born to mothers who are tested as seronegative for human immunodeficiency virus (HIV) \& hepatitis B surface antigen (HBsAg).
- Trial name
- NCT00317122
- Testing
- DTPw-HBV/Hib-MenAC conjugate vaccine
- Where
- 4 sites in South Africa
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dementia
Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer
The overarching goal of this work is to determine methods that improve caregiver education about the behavioral and psychological symptoms (BPSD) of dementia.
- Trial name
- NCT07377331
- Testing
- Structured Retrieval Practice (SRP)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Premature Ventricular Contraction
Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex
Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine.
- Trial name
- NCT03447002
- Testing
- 24 hours urine levels metanephrine and normetanephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
Asthma
Transporter Mediated Uptake of Montelukast
Leukotriene receptor antagonists (LTRAs) are frequently prescribed to reduce the symptoms associated with asthma. Singulair, manufactured by Merck, is a popular LTRA, however its effectiveness varies greatly between individuals.
- Trial name
- TPORT (NCT00513760)
- Testing
- Grapefruit juice, Orange Juice, Gatorade
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Nemours Children's Clinic
Parkinson Disease
Effect of Fecal Microbiota Transfer on Progression of Parkinson Disease
The aim of the study is to assess impact of Fecal Microbiota Transfer (FMT) on clinical symptoms of Parkinson's disease. Assesment of tremor, slowness of movements and balance problems before and after FMT will be performed.
- Trial name
- EFFACE-PD (NCT05204641)
- Testing
- Fecal Microbiota Transfer provided by Human Biome Institute
- Where
- Poland
- Volunteers
- 59 people
- Sponsor
- Medical University of Warsaw
Neuropathic Pain, Nociplastic Pain
Efficacy of Home-delivered Transcranial Direct Electrical Stimulation or Chronic Pain
This clinical investigation aims to evaluate the efficacy and safety of a home-based device providing electrical stimulation of the brain named transcranial direct current stimulation (tDCS ) , in patients with chronic pain who…
- Trial name
- Homestim-DC (NCT07211256)
- Testing
- tDCS of the motor cortex
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospital Ambroise Paré Paris
Acute Stroke
Intra-arterial Magnesium Administration for Acute Stroke
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. This investigation will address the safety and feasibility of directed, intra-arterial Magnesium measurement and therapy, through…
- Trial name
- NCT01502761
- Testing
- Magnesium Sulfate
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Acupuncture Analgesia
Effectiveness of Cheek Acupuncture Therapy for Pain Control After Cesarean Delivery
This study investigates whether cheek acupuncture therapy can alleviate postoperative pain in cesarean section patients and explores its mechanisms of action through a prospective randomized controlled clinical trial.
- Trial name
- NCT06795594
- Testing
- cheek acupuncture, sufentanil 2 µg/kg + ondansetron 0.2 mg/kg
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tongren Hospital
Type 1 Diabetes, Type 2 Diabetes
Automated Insulin Delivery for Inpatients With Dysglycemia
This randomized controlled trial will test the efficacy and safety of automated insulin delivery (AID) in hospitalized patients with diabetes (type 1 or type 2) requiring insulin therapy who are admitted to general…
- Trial name
- AIDING (NCT06418880)
- Testing
- AID system with Remote Real-Time CGM, Standard of Care Insulin Therapy + CGM
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Intellectual Disabilities (F70-F79), Problem;Behaviour;Adult
Mental Health and Healthcare in Adults With Intellectual Disabilities
Intellectual disability (ID) is a diagnosis characterized by significant limitations both in intellectual functioning and in adaptive behavior as expressed in conceptual, social and practical adaptive skills.
- Conditions
- Intellectual Disabilities (F70-F79), Problem;Behaviour;Adult, Mental Health Issue, Employment
- Trial name
- NCT05703503
- Where
- Norway
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Zika Virus Infection on Fetus and Child During the Pregnancy
Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America
The Zika epidemic has spread into the three French Overseas Departments in the Caribbean (DFAs). It is therefore urgent to set up tools to collect clinical and paraclinical data for the evaluation of potential complications due…
- Trial name
- ZIKA-DFA-BB (NCT02810210)
- Testing
- fundus examination, Head ultrasound
- Where
- 6 sites in France, French Guiana and 2 more
- Volunteers
- 1,180 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anaplastic (Malignant) Meningioma, Atypical Meningioma
Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma
The purpose of this research study is to determine the effects bevacizumab (the study drug) combined with Optune (the study device) tumor treatment field therapy has on meningiomas.
- Conditions
- Anaplastic (Malignant) Meningioma, Atypical Meningioma, Grade II Meningioma, Grade III Meningioma
- Trial name
- NCT02847559
- Testing
- Bevacizumab, Electric Field Therapy, NovoTTF-200A Device
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Diabetes, Depression
Behavioral Activation Therapy for Both Depression and Diabetes Vs. Diabetes Alone Delivered Via Group Visits
The purpose of this study is to determine whether group visits with added behavioral activation (BA) for depression will have a greater clinical impact than our standard group visits without BA for depression in reducing the risk…
- Trial name
- BA-MEDIC (NCT02027259)
- Testing
- Behavioral activation (BA)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Providence VA Medical Center
Hypoxia, Brain, Premature Birth
PREMOD2 With Near Infrared Spectroscopy Sub-study
Early hemodynamic effects (within 3 hours of life) of Delayed Cord Clamping compared to Umbilical Cord Milking are still unknown.
- Trial name
- PREMOD2 (NCT03145142)
- Testing
- Umbilical cord milking, Delayed Cord Clamping
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 121 people
- Sponsor
- Sharp HealthCare
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Non Arteritic Anterior Ischemic Optic Neuropathy
Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
This study will determine the effect of QPI-1007 on visual function in subjects with recent-onset NAION and assess the safety and tolerability of intravitreal injections of QPI-1007 in this population.
- Trial name
- NCT02341560
- Testing
- QPI-1007 Injection - 1.5 mg, QPI-1007 Injection - 3.0 mg
- Where
- 85 sites in United States, Australia and 6 more
- Volunteers
- 732 people
- Sponsor
- Quark Pharmaceuticals
Human Immunodeficiency Virus
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
The goal of this clinical trial is to learn if the DSD model (SUSTAIN-DSD) is effective in improving participants HIV treatment adherence.
- Trial name
- NCT06554223
- Testing
- SUSTAIN-DSD, Enhanced (guideline-driven) Standard of Care (E-SoC)
- Where
- South Africa
- Volunteers
- 310 people
- Sponsor
- Brigham and Women's Hospital
HIV-1, HIV Infections
Safety and Immunogenicity Study of Candidate HIV-1 Vaccine Given to Healthy Infants Born to HIV-1/2-uninfected Mothers
Objectives: Safety and immunogenicity of MVA.HIVA vaccine in 20-week-old healthy Gambian infants born to HIV-1/2-uninfected mothers.
- Trial name
- PedVacc001 (NCT00982579)
- Testing
- MVA.HIVA
- Where
- The Gambia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
Healthy, Cystic Fibrosis
Comparison of Amikacin Lung Delivery With Two Nebulizers
Comparison between two modalities of nebulization.
- Trial name
- NCT02538588
- Testing
- Nebulizer 1, Nebulizer 2
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
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