Clinical trials: Delivery Systems
Chronic Pain, Nociplastic Pain
Internet-Delivered Psychological Treatments for Chronic Pain in Adolescents: ACT and Pain Education.
One in four children in Sweden experiences chronic pain. For many, the pain is temporary, but for about 5% it significantly affects daily life, leading to sleep problems, school absence, and reduced physical activity.
- Conditions
- Chronic Pain, Nociplastic Pain, Pain Management, Acceptance and Commitment Therapy
- Trial name
- NCT06981312
- Testing
- Acceptance and Commitment Therapy, Pain Science Education
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Immunodeficiency
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages
These studies are designed to evaluate the relative efficiency of gene transfer into primitive human hematopoietic cells by comparing lentiviral and foamy virus vectors as vehicles for transfer and expression of globin genes.
- Trial name
- NCT00758992
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Parkinson Disease
Effect of Fecal Microbiota Transfer on Progression of Parkinson Disease
The aim of the study is to assess impact of Fecal Microbiota Transfer (FMT) on clinical symptoms of Parkinson's disease. Assesment of tremor, slowness of movements and balance problems before and after FMT will be performed.
- Trial name
- EFFACE-PD (NCT05204641)
- Testing
- Fecal Microbiota Transfer provided by Human Biome Institute
- Where
- Poland
- Volunteers
- 59 people
- Sponsor
- Medical University of Warsaw
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
To compare the use of pentamidine aerosol (inhaled mist) with the standard intravenous method of administration in patients with AIDS related Pneumocystis carinii pneumonia (PCP), to measure the amount of pentamidine aerosol that…
- Trial name
- NCT00000722
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma
Pressure Enabled Delivery of SD-101 With Checkpoint Blockade for Primary Liver Tumors
This is an Open-label, Phase 1b/2 Study of the Pressure-Enabled Hepatic Artery Infusion (HAI) of SD-101, a TLR9 agonist, Alone or in Combination with Intravenous Checkpoint Blockade in Adults with Hepatocellular Carcinoma (HCC)…
- Trial name
- NCT05220722
- Testing
- SD-101, Pembrolizumab, Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- TriSalus Life Sciences, Inc.
Encephalopathy, Birth Defect
Clinical Utility of Pediatric Whole Exome Sequencing
The investigator aims to examine the clinical utility of WES, including assessment of a variety of clinical outcomes in undiagnosed pediatric cases.
- Conditions
- Encephalopathy, Birth Defect, Intellectual Disability, Multiple Congenital Anomaly
- Trial name
- NCT03525431
- Testing
- Whole Exome Sequencing
- Where
- 4 sites in United States
- Volunteers
- 529 people
- Sponsor
- University of California, San Francisco
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
ICBT for Pain-predominant FGIDs in Children and Adolescents: an Implementation Study.
This open trial aims to evaluate feasibility and preliminary effectiveness of an internet-delivered CBT-program for children and adolescents with functional gastrointestinal disorders when implemented in regular care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Dyspepsia, Functional Abdominal Pain
- Trial name
- NCT03252743
- Testing
- Exposure-based internet-delivered CBT
- Where
- Sweden
- Volunteers
- 68 people
- Sponsor
- Karolinska Institutet
Infertility of Tubal Origin
Clinical Evaluation of a Tubal Selective Delivery System
A single center study to evaluate the performance and optimize the design of a novel intrauterine catheter system intended as a nonsignificant risk medical device to aid in evaluating tubal patency as part of the initial…
- Trial name
- NCT05775913
- Testing
- Tubal Selective Delivery System (TSDS)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Childbirth, Pain
Mental Training and Childbirth
Labour pain is a challenge to the parturient woman. Pain relief methods during birth are limited and often associated with side effects.
- Trial name
- NCT00914082
- Testing
- Self hypnosis
- Where
- Denmark
- Volunteers
- 1,222 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
HIV Infections
Safety/Immunogenicity of Immunizations of ALVAC-DC-SC vs ALVAC-SC
The purpose of this study is to determine how safe it is to give patients a shot that has a mixture of a vaccine and dendritic cells (DCs), a special kind of immune cell, and how safe it is to give a shot of the vaccine alone.
- Trial name
- NCT00026624
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), Keyhole-Limpet Hemocyanin
- Where
- 2 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiration; Insufficient or Poor, Newborn, Infant, Premature, Diseases
Comparison Of Respiratory Support After Delivery on Infants Born Before 28 Weeks Gestational Age
Trial purpose: For infants born <28 weeks of age, can initial respiratory resuscitation with new system (low imposed work of breathing and prongs) reduce the frequency of delivery room intubations compared to standard treatment…
- Trial name
- CORSAD (NCT02563717)
- Testing
- T-piece used for respiratory support (several manufacturers), New system used for respiratory support
- Where
- 6 sites in Iceland, Lithuania and 3 more
- Volunteers
- 250 people
- Sponsor
- Baldvin Jonsson
Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease
A Study of the Safety and Efficacy of Prime Editing (PM647a) in Participants With Alpha-1 Antitrypsin Deficiency
The purpose of this study is to evaluate the safety, tolerability, biological activity, and initial efficacy of PM647a, an investigational Prime Editing therapy, in adults and adolescents with Alpha-1 Antitrypsin Deficiency…
- Conditions
- Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease, Alpha-1 Antitrypsin Deficiency (AATD), AATD
- Trial name
- PM647a (NCT07887347)
- Testing
- PM647a
- Volunteers
- 54 people
- Sponsor
- Prime Medicine, Inc.
Retinopathy of Prematurity, Pain Management
Pain Management During Screening for Retinopathy of Prematurity
Abstract Background: Screening examinations for retinopathy of prematurity (ROP) is critical to reduce ROP-related vision loss, however, the procedure is painful and uncomfortable, and topical anesthetics do not completely…
- Trial name
- NCT04767178
- Testing
- Ibuprofen (Sanofi, Istanbul, Turkey), Paracetamol (GlaxoSmithKline, Istanbul, Turkey)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul Medeniyet University
Parkinson's Disease
Safety of CERE-120 (AAV2-NTN) in Subjects With Idiopathic Parkinson's Disease
This is a Phase I dose escalating open-label study designed to assess the safety, tolerability and biologic activity of an in vivo AAV2 mediated delivery of the gene encoding NTN (CERE-120).
- Trial name
- NCT00252850
- Testing
- CERE-120: AAV2-NTN
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Sangamo Therapeutics
Parturition, Analgesia, Obstetrical
Neuraxial Labor Analgesia and the Incidence of Postpartum Depression
Postpartum depression (PPD) affects approximately 15% of women during the first year after giving birth, and is common across cultures. The etiology of postpartum depression is not totally clear.
- Conditions
- Parturition, Analgesia, Obstetrical, Depression, Postpartum
- Trial name
- NCT02823418
- Testing
- No neuraxial labor analgesia, Neuraxial labor analgesia
- Volunteers
- 599 people
- Sponsor
- Peking University First Hospital
Pregnancy, Anxiety
Mandala Coloring in Late Pregnancy
Anxiety, depression and poor sleep are common in the last months of pregnancy and often occur together. Medication options during pregnancy are limited, so simple, safe non-drug methods are needed.
- Conditions
- Pregnancy, Anxiety, Depression, Psychological Stress
- Trial name
- NCT07906743
- Testing
- Mandala Coloring Group
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Fidan Balkaya
Parkinson's Disease
Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
The objective of this study is to evaluate the long-term safety of AAV-GAD delivered bilaterally to the subthalamic nuclei (STN) in participants with Parkinson's disease.
- Trial name
- NCT05894343
- Testing
- AAV-GAD
- Where
- 6 sites in United States
- Volunteers
- 13 people
- Sponsor
- MeiraGTx, LLC
Weight Gain, Anemia, Iron Deficiency
Egg Intervention During Pregnancy in Indonesia
The study consists of two arms: 1) intervention group using eggs as supplementary food given from 2nd trimester of pregnancy to birth, and 2) observational group of pregnant mothers.
- Conditions
- Weight Gain, Anemia, Iron Deficiency, Birth Weight, Birth Length
- Trial name
- PRECODE (NCT04694235)
- Testing
- Egg intervention
- Where
- Indonesia
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Influenza
Phase 1 Evaluation of H1 Influenza Vaccine Delivered by MIMIX MAP
A Phase 1, Randomized, Rater and Participant Blinded Placebo Controlled Study to Evaluate the Safety, Reactogenicity, Tolerability and Immunogenicity of a Standard and a Fractional Dose of H1 Influenza Vaccine Delivered by VX-103…
- Trial name
- NCT06125717
- Testing
- H1 influenza antigen
- Where
- 3 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Terrestrial Bio, Inc.
Secondary Pancreatic Diabetes
Closed-loop Insulin Delivery Systems in Pancreatic Diabetes
The purpose of this study is to evaluate the metabolic and the safety outcomes in people living with pancreatic diabetes (pancreatitis or pancreatectomy-induced diabetes) and using a closed-loop insulin delivery systems…
- Trial name
- IADIASP (NCT06227650)
- Testing
- hybrid closed loop insulin delivery system
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Sud Francilien
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