Clinical trials: Delivery Systems
Diabetes Mellitus, Type 2
Contextualizing Evidence for Action on Diabetes - Population Survey
This protocol reflects the first part of a larger mixed-methods study aimed at exploring the process by which global recommendations can be translated into context-specific, evidence-informed action for diabetes prevention in…
- Trial name
- CEAD (NCT03968380)
- Testing
- Population survey with biological and physical measurements.
- Where
- Ecuador
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Pneumonia, Bacterial
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative and / or Gram-positive Bacterial Colonization
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin Fosfomycin Inhalation System (AFIS) versus aerosolized placebo in mechanically ventilated patients with Gram-negative and / or Gram-positive bacterial…
- Trial name
- NCT02218359
- Testing
- Amikacin Fosfomycin Inhalation Solution
- Sponsor
- Cardeas Pharma
Perinatal Mental Health
Transforming Maternal Mental Health Care
The overall objective of this pilot study is to assess the feasibility of a RCT comparing Lōvu-augmented with usual prenatal care at UU.
- Trial name
- IUFU (NCT07766174)
- Testing
- Lōvu platform, Standard Care Arm
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Ulcerative Colitis
Angiographic Delivery of AD-MSC for Ulcerative Colitis
Researchers are trying to determine the safety and feasibility of using an adipose derived mesenchymal stem cell (MSC) to treat people with Ulcerative Colitis.
- Trial name
- NCT04312113
- Testing
- Adipose derived, autologous mesenchymal stem cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Hypercholesterolemia, Atherosclerosis
Causes and Natural History of Dyslipidemias
This study will evaluate people with dyslipidemias - disorders that affect the fat content in the blood. Fats, or lipids, such as cholesterol and triglycerides, are carried in the blood in particles called lipoproteins.
- Trial name
- NCT00353782
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Infectious Diseases
LoewenKIDS - Infections and the Development of the Immune System
The purpose of this study is to determine in what way infections, microbiome, and vaccinations during childhood interact in shaping the development of immunity and tolerance.
- Trial name
- LoewenKIDS (NCT02654210)
- Testing
- No Intervention
- Where
- 2 sites in Germany
- Volunteers
- 782 people
- Sponsor
- Helmholtz Centre for Infection Research
Degenerative Mitral Valve Disease
EXPLORE DMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation
An early feasibility study to evaluate the safety and feasibility of the PLAR Implant and Delivery System to treat severe degenerative mitral regurgitation and to gather preliminary data on its performance thereby providing…
- Trial name
- NCT04679662
- Testing
- Transcatheter mitral valve repair (PLAR Implant and Delivery System)
- Where
- Brazil
- Sponsor
- Polares Medical SA
Contraception
Early Postpartum Intrauterine Device (IUD) Placement
Women who have just given birth are at high risk for rapid repeat pregnancy, which can lead to negative consequences during the subsequent pregnancy.
- Trial name
- NCT01594476
- Testing
- Levonorgestrel IUS
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
TakeCharge: Telephone Delivered Self-management Intervention for People With Multiple Sclerosis (MS)
The proposed project will evaluate the efficacy of a telephone-delivered self-management (T-SM) intervention for reducing the impact of secondary conditions in persons with multiple sclerosis (MS), including chronic pain…
- Trial name
- TakeCharge (NCT00944190)
- Testing
- Self-management intervention, Education
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Washington
Gulf War Illness, Insomnia
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Sleep disturbance is a common complaint of Veterans with Gulf War Illness (GWI). Because there is clinical evidence that sleep quality influences pain, fatigue, mood, cognition, and daily functioning, this study will investigate…
- Trial name
- CBTi GWI (NCT02782780)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- VA Office of Research and Development
Lowe Syndrome
Genetic Analysis of Oculocerebrorenal Syndrome of Lowe
This study will investigate the genetic basis of oculocerebrorenal syndrome of Lowe (OCRL)-a rare X-linked disorder (carried by females and passed to males).
- Trial name
- NCT00359515
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Prostate Cancer
Lycopene in Preventing Prostate Cancer in Patients Who Are at High Risk of Developing Prostate Cancer
RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of lycopene, a substance found in tomatoes, may keep prostate cancer from forming in patients at…
- Trial name
- NCT00416325
- Testing
- lycopene, laboratory biomarker analysis
- Volunteers
- 18 people
- Sponsor
- University of Illinois Chicago
Neurofibroma
Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas
Plexiform neurofibromas (PN) represent one of the most significant complications of NF1. They are a significant cause of morbidity in neurofibromatosis type 1 (NF1) by causing pain, impaired function, and disfigurement.
- Trial name
- PDT (NCT00716469)
- Testing
- LS11
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Children's Hospital of Philadelphia
Iron Deficiency
Iron Absorption From GDS Capsules II
Slow release iron capsules containing ferrous sulfate have been designed based on the gastric delivery system. Iron absorption from those capsules administered with and without meals will be measured using stable iron isotopes.
- Trial name
- NCT01985386
- Testing
- GDS capsule with meal, Ferrous sulfate with meal
- Where
- Switzerland
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Asthma
Transporter Mediated Uptake of Montelukast
Leukotriene receptor antagonists (LTRAs) are frequently prescribed to reduce the symptoms associated with asthma. Singulair, manufactured by Merck, is a popular LTRA, however its effectiveness varies greatly between individuals.
- Trial name
- TPORT (NCT00513760)
- Testing
- Grapefruit juice, Orange Juice, Gatorade
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Nemours Children's Clinic
Degenerated Mitral Regurgitation
Safety and Effectiveness Study of SQ-Kyrin TMVr System for Degenerated Mitral Regurgitation
To verify the safety and effectiveness of transcatheter mitral valve clip delivery system and steerable guide catheter produced by Shanghai Shenqi Medical Technology Co., Ltd.in patients with moderate-severe or severe degenerated…
- Trial name
- NCT06467110
- Testing
- transcatheter mitral valve clip delivery system and steerable guide catheter (Shenqi Medical)
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shanghai Shenqi Medical Technology Co., Ltd
Acute Stroke
"Mobile Stroke Unit"-Concept for Delivery of Specialized Acute Stroke Care to Patients in Remote Areas
Treatment of acute stroke must be fast. The aim of this trial is to show feasibility, safety and clinical benefit of a strategy of diagnosis and treatment directly at the emergency site for hyperacute treatment and transfer to…
- Trial name
- NCT02465346
- Testing
- MSU-based stroke management, Control stroke management
- Where
- Germany
- Volunteers
- 116 people
- Sponsor
- University Hospital, Saarland
Transcatheter Aortic Valve Implantation
Investigation of the ALLEGRA THV System With a New Delivery System in Patients With Aortic Stenosis or Failed Surgical Bioprosthesis
The EMPIRE study confirms the technical performance of the new IMPERIA Delivery System and evaluates the safety and efficacy of the entire ALLEGRA THV System.
- Trial name
- EMPIRE (NCT05478161)
- Testing
- (ALLEGRA Transcatheter Heart Valve) TAVI in severe calcified aortic stenosis or in failed surgical aortic bioprosthesis
- Where
- 11 sites in Germany, Netherlands and 1 more
- Volunteers
- 137 people
- Sponsor
- NVT GmbH
Infant, Very Low Birth Weight, Infant, Premature
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)
This trial was to determine whether giving low-dose indomethacin to infants weight 500 to 999 grams (approximately 1 to 2 pounds) at birth improves their survival without cerebral palsy or developmental problems at 18 to 22…
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Ductus Arteriosus, Patent
- Trial name
- TIPP (NCT00009646)
- Testing
- indomethacin
- Where
- 9 sites in United States
- Volunteers
- 1,202 people
- Sponsor
- NICHD Neonatal Research Network
HIV/AIDS
Accelerated PrEP Access for Black MSM and TW
The investigators will pilot-test an accelerated PrEP initiation approach among young high-risk Black/African American (B/AA) men who have sex with men (MSM) and transgender women (YMSM/TW) at the point of care in community…
- Trial name
- NCT04329442
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
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