Clinical trials: Dementia, Familial
Dementia
Behavioral Sleep Intervention in Adult Family Homes
Sleep disturbances are widespread among demented residents of board and care homes and are a leading cause for transfer into nursing homes.
- Trial name
- NCT00393627
- Testing
- Sleep Education Program
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Washington
Familial Amyloid Polyneuropathy, ATTR-PN
An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy
This study is designed to determine the long-term safety and tolerability of Fx-1006A as well as the effects of Fx-1006A on clinical outcomes in patients with ATTR-PN.
- Trial name
- NCT00791492
- Testing
- Fx-1006A
- Where
- 11 sites in Argentina, Brazil and 4 more
- Volunteers
- 86 people
- Sponsor
- Pfizer
Transthyretin (TTR) Amyloid Cardiomyopathy
Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy
Open label study to evaluate tafamidis for the treatment of transthyretin cardiomyopathy
- Trial name
- NCT02791230
- Testing
- Tafamidis
- Where
- 80 sites in United States, Argentina and 15 more
- Volunteers
- 1,733 people
- Sponsor
- Pfizer
Suicide, Depression
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
This project aims to adapt, implement, and evaluate a Dialectical Behavior Therapy skills training group intervention for aging adult family caregivers of person with Alzheimer's Disease and Alzheimer's Disease Related Dementias…
- Conditions
- Suicide, Depression, Caregiver Burden, Physical Health
- Trial name
- NCT06055322
- Testing
- Adapted Dialectical Behavior Therapy
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Alzheimer Disease, Dementia
CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders
The prevalence of major neurocognitive disorders (MNCDs), particularly Alzheimer's disease, among older adults is increasing. These individuals and their caregivers often face challenges due to inefficient and poorly coordinated…
- Conditions
- Alzheimer Disease, Dementia, Neurocognitive Decline
- Trial name
- NCT06608589
- Testing
- CoMPAS+ MNCDs Program - Quality improvement program targeting the care transitions of patients living with a major neurocognitive disorder and their caregivers
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Laval University
Alzheimers Disease, Dementia
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with…
- Conditions
- Alzheimers Disease, Dementia, Alzheimers Disease, Familial
- Trial name
- DIAN-TU (NCT01760005)
- Testing
- Gantenerumab, Solanezumab, E2814
- Where
- 38 sites in United States, Argentina and 13 more
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dementia in Nursing Home, Family
Connecting Today to Combat Social Isolation and Loneliness
The investigators developed Connecting Today, a feasible and highly acceptable remote visiting program that can support care home residents living with moderate to severe dementia to have video calls with their family members…
- Conditions
- Dementia in Nursing Home, Family, Remote Visits
- Trial name
- NCT07182019
- Testing
- Connecting Today
- Where
- Canada
- Volunteers
- 320 people
- Sponsor
- University of Alberta
Dementia, Family Relations
Management of Psychological and Behavioral Symptoms in Patients With Dementias
Background: The psychological and behavioral symptoms (SPCD) of dementias are the manifestations that cause the most suffering in the patient and caregiver, worsening the other two symptomatic areas (cognitive and functional) and…
- Conditions
- Dementia, Family Relations, Psychological and Behavioral Symptoms
- Trial name
- PRESTA (NCT03732521)
- Testing
- Educational therapy
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Traumatic Brain Injury, Alzheimer Disease
The Aging Brain ANSWERS Program
This study will test the effectiveness of an intervention for Veterans diagnosed with Alzheimer's Disease (AD) or Traumatic Brain Injury (TBI) and the burden on their informal (family/friend) caregiver.
- Conditions
- Traumatic Brain Injury, Alzheimer Disease, Veterans, Family Caregivers
- Trial name
- ABC ANSWERS (NCT03397667)
- Testing
- ABC ANSWERS, Control
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Indiana University
Alzheimer Disease, Familial Alzheimer Disease (FAD)
The Chinese Familial Alzheimer's Network
This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide.
- Trial name
- CFAN (NCT03657732)
- Where
- 65 sites in China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Dementia, Alzheimer Disease
Learning Skills Together Family Caregiver Complex Intervention
Learning Skills Together (LST) is a 6-week psychoeducational intervention focused on complex care (nursing) tasks completed by family caregivers to persons living with Alzheimer's Disease and related dementias.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burden, Self Efficacy
- Trial name
- LST (NCT05846984)
- Testing
- Learning Skills Together Intervention, Caregiver Healthy Living Intervention
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Autism, Aggression
The Family VOICE Study
Family centered mental health treatment with children values and supports the role of parents in their child's recovery. However, medications are often the primary focus in community treatment, even in preschool age youth, with…
- Conditions
- Autism, Aggression, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT01804582
- Testing
- Family Navigator consultation
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Maryland, Baltimore
Delirium Superimposed on Dementia
Study of the Aliviado DSD Caregiving Mastery Program
Delirium superimposed on dementia (DSD) is an acute and serious condition that is common in persons living with dementia (PLWD). Involvement of family caregivers may aid prevention, early detection, and management of DSD.
- Trial name
- NCT05630014
- Testing
- Aliviado DSD Caregiving Mastery Program
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Amyloidosis, Amyloid Cardiomyopathy
Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy
Phase 3 efficacy and safety study to evaluate acoramidis (AG10) HCl 800 mg administered orally twice a day compared to placebo in subjects with symptomatic Transthyretin Amyloid Cardiomyopathy (ATTR-CM).
- Conditions
- Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis, Cardiomyopathies
- Trial name
- ATTRibute-CM (NCT03860935)
- Testing
- acoramidis
- Where
- 104 sites in United States, Australia and 16 more
- Volunteers
- 632 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
Alzheimer's Disease (AD), Dementia
Negotiation Training for Family Caregivers of People With Alzheimer's Disease
Family caregivers of people living with Alzheimer's disease and related dementias often experience conflicts and communication challenges when coordinating care, making decisions, and interacting with family members and…
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Impairment
- Trial name
- NCT07859540
- Testing
- NegotiAge, PlanYourLifespan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Dementia
Caregiver as Navigator: Develop Skills Online (CAN-DO)
This study is designed to learn more about ways to promote caregiver mastery online. 270 dementia family caregivers will be enrolled and randomized to take the CAN-DO online course immediately or after a waiting period.
- Trial name
- NCT06177990
- Testing
- Caregiver as Navigator: Develop Skills Online (CAN-DO) program, Healthy Living online course
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Emory University
C9ORF72 Amyotrophic Lateral Sclerosis (ALS)
Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS
This research study is being performed to better understand a specific form of Amyotrophic Lateral Sclerosis (ALS) caused by a mutation (or abnormality) of the C9ORF72 gene.
- Trial name
- NCT02686268
- Where
- 8 sites in United States, Netherlands
- Volunteers
- 128 people
- Sponsor
- Washington University School of Medicine
Caregiver Burden, Caregiver Stress Syndrome
Traumatic Brain Injury and Alzheimer's Disease/Related Dementias Caregiver Support Intervention
The TBI-AD/ADRD Caregiver Support Intervention (TACSI) incorporates psychosocial and psychoeducational approaches with the objective of: a) identifying stressors associated with caregiving for family members who have the dual…
- Conditions
- Caregiver Burden, Caregiver Stress Syndrome, Caregiver Burnout
- Trial name
- TACSI (NCT05465109)
- Testing
- TBI-AD/ADRD Caregiver Support Intervention (TACSI)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Carers, Dementia
Family Interventions iN Dementia Mental Health Environments
Study Goal: Understand carers' needs when someone with dementia is in a mental health ward and develop strategies to support carers as partners in care.
- Trial name
- FIND ME (NCT06937541)
- Where
- United Kingdom
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University of West London
Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC), Amyloidosis, Hereditary
ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)
The purpose of this study was to evaluate the safety and efficacy of revusiran (ALN-TTRSC) in patients with transthyretin (TTR) mediated Familial Amyloidotic Cardiomyopathy.
- Conditions
- Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC), Amyloidosis, Hereditary, Amyloid Neuropathies, Familial, Amyloid Neuropathies
- Trial name
- NCT02319005
- Testing
- Revusiran (ALN-TTRSC), Sterile Normal Saline (0.9% NaCl)
- Where
- 61 sites in United States, Belgium and 7 more
- Volunteers
- 206 people
- Sponsor
- Alnylam Pharmaceuticals