Clinical trials: Dementia, app or software or digital or wearable or device or sensor, open to volunteers
- Condition Dementia
- Drug or intervention app OR software OR digital OR wearable OR device OR sensor
- Status Open to volunteers
Alzheimer Disease (AD)
Alzheimer's Disease Treated With Vagus Nerve Stimulation
The goal of this clinical trial is to evaluate the safety and efficacy of vagus nerve stimulation (VNS) for treating Alzheimer's disease (AD) in patients aged 50-80 years with mild cognitive impairment to moderate Alzheimer's…
- Trial name
- Advant (NCT06923007)
- Testing
- Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Dementia, tDCS
The Efficacy of HD-tDCS-Augmented Step Training in Older Adults With Mild Dementia
Falls and mobility decline are major health concerns among older adults with dementia, often linked to deterioration in executive function and cognitive-motor control.
- Conditions
- Dementia, tDCS, Physical Exercise, Neuromodulation
- Trial name
- NCT07841145
- Testing
- Step training, active HD-tDCS
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The Hong Kong Polytechnic University
Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB)
Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies
Progressive supranuclear palsy (PSP), mild cognitive impairment with Lewy bodies (MCI-LB), and Dementia with Lewy Bodies (DLB) are severe neurodegenerative diseases that cause significant motor impairment impacting daily…
- Conditions
- Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB), PSP, Lewy Body Dementia (LBD)
- Trial name
- NCT07240805
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- BioSensics
Dementia
AI4HOPE Pilot Study 1 Digital Toolkit Assessment
The pilot study will develop and test a standardized assessment toolkit that will provide conclusive information with a tolerable burden for cognitively impaired patients with dementia.
- Trial name
- AI4HOPE1 (NCT06289322)
- Testing
- Digital toolkit for assessment
- Volunteers
- 150 people
- Sponsor
- University of Bonn
Alzheimer Disease, Dementia, Mild
Paper-Based and Smartphone-Based Memory Supports
Alzheimer's disease and related dementias lead to marked declines in daily functioning, independence, and quality of life. One of the earliest cognitive changes in these conditions is impairment in prospective memory, or the…
- Conditions
- Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
- Trial name
- NCT06444841
- Testing
- Digital - Google Calendar, Paper-based - Memory Support System
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baylor University
Alzheimer Disease, Dementia
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
The estimated annual cost of dementia in Canada is $15 billion, with a projected cumulative economic burden of $800 billion by 2038.
- Trial name
- BIMII (NCT03035851)
- Testing
- Aerobic exercise, Stretch and Strength
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- University of Calgary
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Alzheimer s Disease, MCI Conversion to Dementia
Development of a Home Test for Measuring Blood P-tau217 in Alzheimer's Disease Using the Tasso Lancet Device
This study compares p-tau217 concentrations in blood collected via the Tasso device versus standard venipuncture in subjects with and without Alzheimer's disease, including a subset with confirmed amyloid pathology.
- Conditions
- Alzheimer s Disease, MCI Conversion to Dementia, pTau217, Biomarkers
- Trial name
- NCT07701161
- Where
- 5 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neurogen Biomarking LLC
Motor Disorders
Combined Artificial Intelligence and Mobile Application for Remote Infant Motor Screening: Development and Validation
The purpose of this study is therefore five-fold: (1) designation of an APP "Baby Go" version 3.0 to include the assessment, follow-up, and education functions for parental use at home, (2) development and validation of the AI…
- Trial name
- NCT06521918
- Where
- Taiwan
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Apathy, Apathy in Dementia
Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)
The goal of this trial is to learn whether home-based robotic interventions can reduce apathy in people with cognitive decline. Apathy means reduced motivation, interest, or initiative in daily life.
- Trial name
- RAPHAel (NCT07404410)
- Testing
- telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- Giovanna Zamboni
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease
The Safety and Efficacy of Sodium Pentaborate Pentahydrate in Patients With Mild to Moderate Alzheimer's Disease
Alzheimer's disease (AD) is the leading cause of dementia, affecting millions worldwide. With its global prevalence steadily increasing, particularly in low- and middle-income countries, the demand for effective treatments has…
- Trial name
- NCT06840054
- Testing
- Sodium Pentaborate Pentahydrate
- Volunteers
- 30 people
- Sponsor
- Tabriz University of Medical Sciences
Logopenic Progressive Aphasia, Primary Progressive Aphasia
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
AD afflicts over 5.5. million Americans and is one of the most expensive diseases worldwide. In AD the variant in which language functions are most affected are referred to as 'logopenic variant Primary Progressive Aphasia'…
- Trial name
- NCT03887481
- Testing
- High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks.
- Trial name
- NCT06094192
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Mild Cognitive Disorder, Alzheimer Disease
Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family Caregivers
Around 57 million people worldwide live with dementia, with approximately 10 million new cases diagnosed each year. By the end of 2023, around 1.8 million people were living with dementia in Germany, the majority of whom were…
- Conditions
- Mild Cognitive Disorder, Alzheimer Disease, Vascular Dementia, Dementia in Other Diseases Classified Elsewhere
- Trial name
- digiDEM Bayern (NCT07721701)
- Where
- 12 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Mild Cognitive Impairment, Alzheimer's Disease
Use of Wearables for Identifying Factors Associated With Mild Cognitive Impairment and Early-Stage Alzheimer's Disease
Cognitive decline affects millions of older adults worldwide and has a profound impact on individuals, families, and healthcare systems.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Dementia
- Trial name
- NCT07391436
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Getúlio Vargas University Hospital
Aging, Mild Cognitive Impairment
China Longitudinal Aging and Cognitive Impairment Study
This is a multi-center longitudinal study that consists of five cohorts: cognitive normal aging (CN), Subjective cognitive impairment (SCI), mild cognitive impairment (MCI), Alzheimer's disease (AD) and vascular cognitive…
- Conditions
- Aging, Mild Cognitive Impairment, Alzheimer Disease, Neurodegeneration
- Trial name
- CLACIS (NCT05468905)
- Testing
- None of intervention
- Where
- 2 sites in China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged…
- Trial name
- WellderlyBrain (NCT07646054)
- Testing
- Education
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Scripps Translational Science Institute
Alzheimer Disease, Parkinson Disease
Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease
The goal of this clinical trial is to learn about the application of domestic PET/MR in major brain diseases. The main questions it aims to answer are: Overcome the bottleneck of early accurate diagnosis and treatment in major…
- Conditions
- Alzheimer Disease, Parkinson Disease, Epilepsy, Malignant Brain Tumor
- Trial name
- CAMIND (NCT06092125)
- Testing
- PET/MR
- Where
- China
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing