Clinical trials: Dementia, completed
Agitation Associated With Dementia of the Alzheimer's Type
Brexpiprazole for the Long-term Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
To evaluate the safety of brexpiprazole 1 mg or 2 mg after a 14 week treatment regimen for agitation associated with dementia of the Alzheimer's type patients who completed in a double-blind trial, and to investigate the efficacy…
- Trial name
- NCT03724942
- Testing
- Brexpiprazole
- Where
- Japan
- Volunteers
- 164 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Alzheimer's Disease, Dementia
A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of NIC5-15 in the treatment of Alzheimer's Disease.
- Trial name
- NCT01928420
- Testing
- Drug: NIC5-15
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Humanetics Corporation
Methamphetamine Abuse, HIV/AIDS
The Getting Off App for Methamphetamine-Using Gay and Bisexual Men
A commonly used manualized outpatient methamphetamine intervention for gay and bisexual men, "Getting Off," is being translated into a mobile phone application (i.e., app) available for download through common app marketplaces.
- Trial name
- NCT03884946
- Testing
- Getting Off App
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Friends Research Institute, Inc.
Autism Spectrum Disorder
CPI Training for Parents of Children With ASD
The purpose of this 24-week study is to determine whether the "Parent-based Crisis Prevention Institute (CPI) physical management training program" (i.e., P-CPI) is effective in increasing self-efficacy in parents of children…
- Trial name
- NCT03537261
- Testing
- Parent-based Crisis Prevention Institute (CPI) physical management training program (P-CPI)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Substance Use Disorder (SUD)
A Study of a Mobile Phone Application Measuring the Eyes Before and After Medication
This is a post-market clinical follow-up study on an approved CE-marked eHealth system where a mobile phone application is used to measure the pupils and eye measurements to monitor the use of different drug substances.
- Trial name
- NCT06629740
- Testing
- Measurements with a eHealth system
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Alzheimer Disease
Holistic Nursing Benefits Cognitive and Psychiatric Symptoms in Alzheimer's Patients
This clinical study aims to evaluate the effects of a holistic nursing (HN) intervention on cognitive function, psychological well-being, and overall health outcomes in patients with Alzheimer's disease (AD).
- Trial name
- NCT06868004
- Testing
- Holistic Nursing
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The First People's Hospital of Jingzhou
Dementia
Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia
In the Netherlands a rapidly increasing number of multidisciplinary memory clinics (MMC) currently diagnose 25% of the patients with dementia.
- Trial name
- AD-Euro (NCT00554047)
- Testing
- Multidisciplinary Memory Clinic, General Practitioners
- Where
- 9 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Alzheimer Disease
Safety and Efficacy of Positron Emission Tomography (PET) Imaging With MNI-558
This research will look at how the brain may change in people with Alzheimer disease (AD). The purpose of this research is to find out whether changes in the brain in people with Alzheimer disease can be detected using a brain…
- Trial name
- MNI-558 (NCT01217021)
- Testing
- [18F] MNI-558
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Caregiver Stress Syndrome
Positive Dementia Caregiving: Clinical Trial of an Online Training Program
The goal of this study is to learn if a new online training program is helpful to dementia family caregivers. This online program is fully computerized and supports 24/7 access from any location.
- Trial name
- NCT06409455
- Testing
- Positive Dementia Caregiving in 30 Days
- Where
- Hong Kong
- Volunteers
- 274 people
- Sponsor
- Education University of Hong Kong
Aggression, Physical Restraint
The Effectiveness of De-escalation in Management of Aggression
A multicenter, intervention study will be conducted in all psychiatric hospitals in Slovenia. The purpose of the study is to evaluate the effect of verbal and non-verbal de-escalation techniques on the incidence and severity of…
- Conditions
- Aggression, Physical Restraint, Education
- Trial name
- EDtAC_AC (NCT05166278)
- Testing
- De-escalation training
- Where
- 6 sites in Slovenia
- Volunteers
- 6 people
- Sponsor
- University Medical Centre Maribor
Depression
Cognitive Correlates of Antidepressant Treatment Response in Elders
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants".
- Trial name
- NCT01477268
- Testing
- Zoloft (antidepressant)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Alzheimer's Disease
Improved Diagnosis of Alzheimer's Disease Using Magnetoencephalography (MEG)
The current study is intended to enrich and extend the database of Alzheimer's Disease (AD) and healthy control (HC) MEG scans and will include patients meeting DSM-IV-TR criteria for dementia of Alzheimer's type, and age- and…
- Trial name
- NCT00973518
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.
Healthy, Alzheimer Disease
Study With Lu AF87908 in Healthy Participants and Participants With Alzheimer's Disease
The purpose of this study is to investigate the safety of a single dose of Lu AF87908, how well it is tolerated and what the body does to the drug in healthy participants and participants with Alzheimer's disease.
- Trial name
- NCT04149860
- Testing
- Lu AF87908
- Where
- 6 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Dementia
Community Paramedic Coaching Program for Caregivers and People With Dementia
This pilot study is designed to evaluate the potential effectiveness of the implementation strategy and intervention delivery model of a community paramedic coaching program for caregivers of persons with dementia, in direct…
- Trial name
- CP3D (NCT04239924)
- Testing
- Paramedic Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Vascular Cognitive Impairment no Dementia
Cog-VACCINE: Cognitive Training in Patients With Vascular Cognitive Impairment, no Dementia
This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with subcortical VCIND. Half of participants will receive multi-domain adaptive internet-based training program, while the other…
- Trial name
- Cog-VACCINE (NCT02640716)
- Testing
- multi-domain internet-based adaptive training program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Age-Related Memory Disorders
Nintendo Wii Virtual Reality Application In Dementia
•This study was planned to investigate the effects of the Nintendo Wii virtual reality application on muscle strength and fall risk in individuals with AD.
- Trial name
- NCT04819126
- Testing
- Nintendo Wii Virtual Reality Application
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kırıkkale University
Healthy
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54861911 in Healthy Elderly Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple-ascending dose JNJ-54861911 which is currently being developed for the treatment of Alzheimer's disease.
- Trial name
- NCT01887535
- Testing
- JNJ-54861911 3 mg, JNJ-54861911 10 mg, JNJ-54861911 30 mg
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Substance-related Disorders
Effects of Fatty Acid Supplementation on Substance Dependent Individuals
Many substance dependent individuals continue to abuse a variety of substances during treatment for their disorder. Often, substance dependent individuals are co-diagnosed with depression and violence problems.
- Trial name
- NCT00312455
- Testing
- Pro-eicosapentaenoic acid (EPA), Pro-docosapentaenoic acid (DPA)
- Sponsor
- National Institute on Drug Abuse (NIDA)
Prion Disease, Dementia
Enhanced CJD Surveillance in the Older Population
The purpose of this study to investigate if cases of Creutzfeldt-Jakob Disease (CJD) and other forms of prion disease are being missed in older adults living within Lothian.
- Trial name
- NCT02629640
- Testing
- Medical history questionnaire, Clinical assessment and review, Participant follow-up
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
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