Clinical trials: Dementia, completed
Anger, Aggression
The Peace of Mind and Body Project: Treatment Development of Yoga for Anger Management in Incarcerated Adults
The investigators will conduct a pilot randomized clinical trial (n = 40) of hatha yoga vs. a health education group (attention control) for prisoners high in self-reported anger dysregulation.
- Trial name
- POMB (NCT05336123)
- Testing
- Hatha Yoga, Health Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Depression, Mental Health Issue
Economic Evaluation of the MEWE Intervention
Cash transfers have shown promise in preventing intimate partner violence, and in reducing recipients' stress levels. Cash transfers with behavioral or psychological interventions have shown limited effectiveness at reducing…
- Conditions
- Depression, Mental Health Issue, Intimate Partner Violence, Domestic Violence
- Trial name
- MEWE-EE (NCT05598697)
- Testing
- Life Skills Building (LSB) curriculum for males, Life Skills Building (LSB) curriculum for females, Cash transfer to adult females
- Where
- Pakistan
- Volunteers
- 1,536 people, healthy volunteers welcome
- Sponsor
- London School of Economics and Political Science
Alzheimer Dementia, Dementia Disorders
Medication Repurposing to Stop Cognitive Decline in Dementia
Dementia creates a great personal and societal burden and there are currently no treatments to stop memory loss. Many patients with dementia take medications to treat other conditions, e.g. high blood pressure and cholesterol.
- Trial name
- NCT05817188
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Karolinska Institutet
Dementia, Pain
Aggression Prevention Training for Caregivers of Persons With Dementia (APT)
This study will evaluate whether a home-based targeted education and skill training (Aggression Prevention Training or APT) will reduce aggression in persons with dementia (PWD) and pain/pain-related features more than usual care…
- Conditions
- Dementia, Pain, Alzheimer's Disease, Aggression
- Trial name
- APT (NCT02380703)
- Testing
- Aggression Prevention Training (APT), Enhanced Usual Primary Care (EU-PC)
- Volunteers
- 239 people
- Sponsor
- Baylor College of Medicine
Alzheimer Disease
Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer's Disease
Photobiomodulation (PBM) describes the use of near-infrared light (which is not visible to the eye) to heal and protect tissue that has either been injured, is degenerating, or else is at risk of dying.
- Trial name
- PBMbiomarker (NCT03405662)
- Testing
- Vielight Neuro Gamma
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Francisco
Dementia
Cognitive Behavioural Therapy of Early Dementia
A randomized, controlled, parallel-group trial to evaluate the efficacy of a cognitive behavioral therapy for patients with early dementia.
- Trial name
- KORDIAL (NCT00735046)
- Testing
- Cognitive behavioral therapy for early Alzheimer's disease, Control
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Cognitive Impairment, Atrial Fibrillation
Atrial Fibrillation Follow-up Investigation to Recover Memory and learnING Trial
The objective of the study is to evaluate the effectiveness of cognitive training in people with atrial fibrillation and cognitive decline over 12-week cognitive training.
- Trial name
- AFFIRMING (NCT05374642)
- Testing
- cognitive training, active control
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Dementia
Extension Connection Evaluation
This study will perform a retrospective analysis to evaluate the effectiveness of a multicomponent educational intervention to improve medication use and management of behavioral and psychological symptoms of dementia, relative…
- Trial name
- ExConEval (NCT02455310)
- Testing
- Educational activities to improve dementia care
- Where
- United States
- Volunteers
- 44,524 people
- Sponsor
- Ryan M. Carnahan
Agitation, Dementia
Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks.
- Trial name
- LiBBY (NCT05644262)
- Testing
- T2:C100
- Where
- 10 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Stoke, Dementia
Evaluation of Usage and Efficacy of the 656 Online Platform for Reducing Caregiver Stress in Chinese Caregivers
This study aimed to assess the efficacy of a new online platform, 656 Online Platform, in Hong Kong in reducing caregiver stress and enhancing caregiver preparedness and competence of caring for older adults with stroke…
- Conditions
- Stoke, Dementia, Fall and Fractures Prevention
- Trial name
- NCT06771557
- Testing
- 656 Online Platform
- Where
- Hong Kong
- Volunteers
- 287 people
- Sponsor
- Hong Kong Metropolitan University
Anxiety Acute, Anxiety Fear
Paediatric Peri-operative Anxiety: Does the Little Journey App Help?
To evaluate the clinical effectiveness of a virtual reality psychological preparation app at reducing peri-operative anxiety and its associated sequelae in children aged 3-12 years old undergoing ambulatory surgery compared to…
- Conditions
- Anxiety Acute, Anxiety Fear, Peri-operative, Psychological Distress
- Trial name
- NCT03797716
- Testing
- Little Journey app
- Where
- 17 sites in United Kingdom
- Volunteers
- 596 people, healthy volunteers welcome
- Sponsor
- University College, London
Caregiver Burden, Dementia
Progressive Muscle Relaxation Exercise on Care Burden, Depression, Anxiety, and Stress Levels in Dementia Caregivers
Dementia, which leads to deterioration in cognitive and behavioral functions, is a chronic progressive disease. Since the diagnosis is made, the care needs of the patients increase.
- Trial name
- NCT06143826
- Testing
- Progressive muscle relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Atlas University
Alzheimer's Disease
A Study to Test the Performance of the CogState Computerized Neuropsychological Battery in Patients With Alzheimer's Disease (0000-086)(COMPLETED)
This study will evaluate the performance of the CogState computerized neuropsychological battery, Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) and Alzheimer's Disease Cooperative Study - Activities of Daily…
- Trial name
- NCT00777608
- Testing
- Donepezil 5 - 10 mg, Donepezil 10 mg
- Volunteers
- 106 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease
Multiple Ascending Dose Study of TC-5619 in Healthy Elderly Subjects and Subjects With Alzheimer's Disease
This is a Phase 1 study to examine the safety, tolerability and pharmacokinetics of TC-5619 in elderly subjects with and without Alzheimer's disease.
- Trial name
- NCT01254448
- Testing
- TC-5619
- Where
- 10 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Functional Aging, Subjective Cognitive Concerns
A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
This intervention is designed to promote enhanced use of compensation strategies including calendar and task list use, and organization systems, as well as increased engagement with brain health activities including physical…
- Conditions
- Functional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health Activities
- Trial name
- NCT03549078
- Testing
- Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Metabolic Syndrome, Normal Cognition
Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
Background: In Alzheimer s disease (AD) the brain cannot use glucose as a fuel. The brain can use ketones as a fuel instead of glucose. Researchers want to test a supplement, Ketone Ester (KE).
- Trial name
- NCT04421014
- Testing
- Ketone Ester drink
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- National Institute on Aging (NIA)
Alzheimer Disease
A Study of the Effects on Sleep, Attention, and Gastrointestinal Tolerance of Galantamine and Donepezil in Patients With Alzheimer's Disease
The purpose of this study is to evaluate the relative effects of galantamine compared to donepezil (both cholinesteraste inhibitors), on sleep, attention, and gastrointestinal tolerance in patients with Alzheimer's disease.
- Trial name
- NCT00035204
- Testing
- galantamine
- Volunteers
- 63 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alzheimer's Disease
Observational Study to Monitor Long-term Immunogenicity and Efficacy of UB 311 Vaccine in Subjects With Alzheimer's Disease
The purpose of this observational study is to determine whether the vaccine (UB 311), targeting the N-terminal amino acids (1-14) of the amyloid beta peptide, has long-term immunogenicity and efficacy in individuals diagnosed…
- Trial name
- NCT01189084
- Testing
- Observational
- Where
- 2 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- United Biomedical
Dementia, Diagnostic Tests, Routine
SIB-Norwegian Version, Validation and Reliability Study
The purpose of this study is to validate and to test interrater reliability for the Norwgian version of Severe Impairment Battery (SIB).
- Trial name
- NCT00449384
- Testing
- Diagnostic Screening
- Where
- Norway
- Volunteers
- 59 people
- Sponsor
- Sykehuset Innlandet HF
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