Clinical trials: Dementia, completed
Alpha-Synucleinopathy, Parkinson's Disease
Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the Brain
The overall goal of this protocol is to evaluate [18F]MNI-1216 (also known as [18F]ACI-12589) as an α-synuclein targeted radiopharmaceutical in 3 parts as follows: Part 1: first in human (FiH) imaging Optional Part 2: expansion…
- Conditions
- Alpha-Synucleinopathy, Parkinson's Disease, Dementia With Lewy Bodies, Multisystem Atrophy
- Trial name
- NCT06445465
- Testing
- [18F]MNI-1216
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Invicro
Huntington's Disease
A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
The primary purpose of this study is to assess the effect of food upon the pharmacokinetics (PK) of SEN0014196 in subjects with Huntington disease (HD).
- Trial name
- NCT01485965
- Testing
- SEN0014196
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Siena Biotech S.p.A.
Down Syndrome (DS)
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool
Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is postulated to modulate dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) and amyloid beta precursor protein (APP) gene overexpression in…
- Trial name
- NCT01699711
- Testing
- Epigallocatechin-3-gallate (EGCG)
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- Parc de Salut Mar
Vascular Dementia
Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia
The purpose of this study is to examine the efficacy and safety of cholinesterase inhibitor (donepezil hydrochloride) Aricept in patients with vascular dementia (VaD).
- Trial name
- NCT00165763
- Testing
- donepezil hydrochloride (Aricept)
- Where
- 2 sites in Philippines
- Volunteers
- 36 people
- Sponsor
- Eisai Inc.
Down Syndrome, Alzheimer's Disease
Down Syndrome Biomarker Initiative (DSBI)
Non-randomized natural history study involving 12 subjects with Down Syndrome, who are aged 30-60 years old. This study will observe 3 different groups: four non-demented subjects between ages 30-40 years old, four non-demented…
- Trial name
- DSBI (NCT02141971)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Michael Rafii
Dementia
A Mobile Phone-based Intervention on Dementia Patients' Caregivers in Vietnam
Background: The growing number of older people with dementia increases demand on informal caregivers who lack information and skills, leading to a high psychological burden in care provision.
- Trial name
- NCT04958707
- Testing
- Information including knowledge and skills related to dementia patient care, Usual care
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
AIDS Dementia Complex, HIV Infections
A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)
The purpose of this study is to determine the safety and effectiveness of memantine, an experimental drug, in improving AIDS dementia complex (ADC). The symptoms of ADC can be improved with zidovudine (ZDV).
- Trial name
- NCT00000867
- Testing
- Memantine
- Where
- 19 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Alzheimer Disease
Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type
The purpose of this study is to learn if aripiprazole is safe and effective in the treatment of psychosis associated with dementia of the Alzheimer's type.
- Trial name
- NCT00036114
- Testing
- aripiprazole
- Where
- 41 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Dementia
Study of Mirtazapine for Agitation in Dementia
This clinical trial evaluates whether Mirtazapine is more effective than placebo in treating agitation in people with dementia. The trial will assess the safety, clinical and cost effectiveness of the treatment.
- Trial name
- SYMBAD (NCT03031184)
- Testing
- Mirtazapine
- Where
- United Kingdom
- Volunteers
- 207 people
- Sponsor
- University of Sussex
Polypathology and Autonomy Loss
Using Environmental Light Therapy to Improve Sleep and Neuropsychiatric Symptoms in Dementia
Alzheimer's disease and related syndromes (AD) is a disease affecting memory but also the relationship with the environment and empower people.
- Trial name
- SOLEIL SOMMEIL (NCT02829892)
- Testing
- Light therapy
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Primary Progressive Aphasia
Communication Bridge 2
This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA).
- Trial name
- CB2 (NCT03371706)
- Testing
- Communication Bridge™, Evidence-Based Impairment Focused
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Chicago
Alzheimer's Disease
Multiple Dose Study of TRx0037
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of TRx0037 after multiple doses in elderly volunteers.
- Trial name
- NCT01253499
- Testing
- TRx0037
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- TauRx Therapeutics Ltd
Agitation, Postoperative Pain
Comparison of Ketamine-propofol Combinations
ASA I-II 3-12 years old children participated to this study. All Participants will divide into the three groups. In Groups I, 2,5 mg/kg propofol and 0,5 mg/kg ketamine will apply at anaesthesia induction.
- Trial name
- NCT02848963
- Testing
- Ketamine-propofol mixture
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Cukurova University
Alzheimer Disease
Telomerase Activator and Retinal Amyloid
A method of detecting amyloid in the retina has been developed. A specially designed retinal camera will directly visualze and record retinal amyloid and via image processing will generate a number: the retinal amyloid index…
- Trial name
- NCT02530255
- Testing
- cycloastragenol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chippewa Valley Eye Clinic
Alzheimer Disease
Socially Assistive Robots for Interaction With Older Adults With Dementia
A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects.
- Trial name
- NCT04384978
- Testing
- Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DreamFace Technologies, LLC
Mild Cognitive Impairment (MCI), Dementia
Exercise Workshop, Skill-Based Art Approaches, and Awareness Studies for Elderly Individuals
Purpose: The aim of the project is to contribute to the physical, social, and psychological well-being of elderly individuals with cognitive impairment within a multidisciplinary approach framework, and to increase the level of…
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Alzheimer Disease, Geriatric Rehabilitation
- Trial name
- NCT07016893
- Testing
- Healthy aging interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul University - Cerrahpasa
Cognitive Symptom, Pre Senile Dementia
Compensatory Training to Support Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease
The Researchers are trying to better understand if behavioral interventions can help improve memory compensation and engagement in healthy lifestyle behaviors in those with memory concerns but normal mental status exam.
- Conditions
- Cognitive Symptom, Pre Senile Dementia, Alzheimer Disease
- Trial name
- NCT04118985
- Testing
- Cognitive rehabilitation and health behavior change intervention, Self-implementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dementia, Agitation
Continuing Education in Nursing Home Dementia Care
This is a single-blinded controlled cluster-randomized intervention trial recruiting staff from 24 NHs in three counties in the region of Western Norway, randomly selected from the total NH population in the region.
- Trial name
- MEDCED (NCT01715506)
- Testing
- Educational intervention
- Where
- 24 sites in Norway
- Volunteers
- 274 people
- Sponsor
- Bergen University College
Alzheimer Disease
18-Month Study of the Efficacy of Xaliproden (SR57746A) in Patients With Mild-to-Moderate Dementia of the Alzheimer's Type
The purpose of this study is to assess xaliproden's potential capacity of slowing the deterioration of cognitive and global functions in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00103649
- Testing
- xaliproden (SR57746A)
- Where
- 121 sites in United States, Canada
- Volunteers
- 1,306 people
- Sponsor
- Sanofi
Early Onset Alzheimer Disease, Frontotemporal Dementia
RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia
The RHAPSODY-plus project consists of two parts. In a first step carers of people with young onset dementia (YOD; onset before the age of 65) have the opportunity to use the RHAPSODY online program (Kurz et al., 2016) to inform…
- Trial name
- RHAPSODY-plus (NCT03923517)
- Testing
- RHAPSODY online program and MEET online sessions
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
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