Clinical trials: Dementia, completed
Alzheimer Disease
Does EVOO Induce Gene and Metabolic Changes in Healthy Subjects
Investigators' recent findings from the pilot clinical trial in MCI individuals demonstrated EVOO improved vascular function and memory.
- Trial name
- NCT05929924
- Testing
- Extra virgin olive oil
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Augusta University
Mild Cognitive Impairment, Lewy Body Dementia, Parkinson's Disease Rapid Eye Movement Sleep Behavior Disorder, Parkinson's Disease Dementia
A Study of Clenbuterol (CST-103) Co-administered With Nadolol (CST-107) in Subjects With Neurodegenerative Disorders
This is a Phase II, randomized, placebo-controlled, double-blind, crossover study on the CNS and pharmacodynamic effects of clenbuterol (CST-103) co-administered with nadolol (CST-107) in 4 subject populations with…
- Trial name
- CLIN-011 (NCT04739423)
- Where
- 7 sites in Australia, New Zealand and 1 more
- Volunteers
- 41 people
- Sponsor
- CuraSen Therapeutics, Inc.
Caregiver Burnout
Mindfulness Based Dementia Care Study
Mindfulness based stress reduction (MBSR) refers to a particular type of attention focused on the present moment, non-judgmental awareness, and acceptance of that experience with openness and curiosity.
- Trial name
- NCT04062227
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Dementia, Relation, Family
Gentle Gymnastics and Relationship Between Family Caregivers and Residents With Dementia in Nursing Homes
The goal of this multicentre cluster randomised controlled trial is to evaluate the effects of a joint practice of a Tai Chi inspired gymnastics programme in nursing home on the relationship between family caregivers and…
- Trial name
- NCT05686486
- Testing
- Tai Chi inspired gymnastics
- Where
- 4 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondation Mederic Alzheimer
Alzheimer Disease
Eye to Brain Connection
This is a non-randomized, non-treatment, observational study designed to discover correlations between retinal imaging and amyloid PET imaging. Subjects will be recruited to the clinical cohort from referring physicians.
- Trial name
- NCT05215782
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Optina Diagnostics Inc.
Aggression, Adolescence
Wise Intervention for Reducing Aggressive Behaviors and Promoting Prosocial Behaviors Toward LGB-TNB Individuals
This study evaluates the effectiveness of a wise Intervention to reduce aggressive behaviors and promote prosocial behaviors toward LGB-TNB individuals among Spanish adolescents.
- Trial name
- LGB-TNB (NCT07212283)
- Testing
- Wise Intervention LGB-TNB, Values alignment wise intervention
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Dementia, Alzheimer's Disease
Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia
Alzheimer's disease and related disorders (AD2) are characterised by cognitive changes and Behavioural and Psychological Symptoms of Dementia (BPSD).
- Conditions
- Dementia, Alzheimer's Disease, Neurocognitive Disorders
- Trial name
- LUMEENCOMPAD (NCT04769024)
- Testing
- LUMEEN Virtual Reality sessions, Control/non-digital stimulation sessions
- Where
- 6 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Aging, Healthy, Risk Reduction
The REMINDER Program for Older Adults Supported by Residential and Daycare Facilities
Dementia and mild cognitive impairment (MCI) deeply impact individuals' well-being and are expected to increase due to population aging, with global cases projected to rise to 152.8 million by 2050.
- Conditions
- Aging, Healthy, Risk Reduction, Old Age; Dementia
- Trial name
- REMINDER (NCT06733181)
- Testing
- REMINDER intervention
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Mild Cognitive Impairment, Dementia, Mild
Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment
The goal of this clinical trial is to compare a precision medicine approach to the standard-of-care for people with mild cognitive impairment or early-stage dementia.
- Trial name
- EVANTHEA (NCT05894954)
- Testing
- Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alzheimer's Prevention and Reversal Project, Inc.
Alzheimer's Disease
Evaluation of PET Scan Timing Relative to AV-45 Injection Time
This study will re-read 10-minute positron emission tomography (PET) scans acquired in previous clinical studies of AV-45 at 30 and 50 minutes after injection and compare the results.
- Trial name
- NCT01565356
- Testing
- florbetapir F 18
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer's Disease
Monetary Cost of Alzheimer's Disease in China
The purpose of the study is to estimate the Chinese economic burden in patients with Alzheimer's Disease (AD).
- Trial name
- NCT02694445
- Testing
- observation
- Where
- China
- Volunteers
- 3,098 people
- Sponsor
- Beijing Friendship Hospital
Alzheimer Disease, Vascular Dementia
A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
The purpose of this study is to evaluate the safety and efficacy of galantamine (a drug for treating dementia) compared to placebo in the treatment of patients with dementia related to cerebrovascular disease (vascular dementia)…
- Trial name
- NCT00261573
- Testing
- galantamine hydrobromide
- Volunteers
- 593 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Dementia
Self-management and HeAlth Promotion in Early-stage Dementia With E-learning for Carers
This study aims to assess if an educational programme combining approaches of self-management, health promotion, and e-learning will improve self-efficacy and other key health and mental health outcomes for people with mild to…
- Trial name
- SHAPE (NCT04286139)
- Testing
- SHAPE
- Where
- 5 sites in Australia, Norway and 1 more
- Volunteers
- 210 people
- Sponsor
- Helse Stavanger HF
Alzheimer's Disease
Cognitive Changes in Alzheimer's Disease Patients Associated With or Without White Matter Changes After Rivastigmine
The purpose of this study is to evaluate and compare the changes of cognitive function (as measured by ADAS-Cog) in the two group of patients with Alzheimer's disease (AD) associated with and without white matter changes after…
- Trial name
- CAREER (NCT01380288)
- Testing
- rivastigmine patch
- Where
- 16 sites in South Korea
- Volunteers
- 300 people
- Sponsor
- Dong-A University
Mild Cognitive Impairment, Dementia
SCGs as a Proxy for Determining the Cognitive Status of Older Adults
Detecting memory problems early is crucial for treating conditions like Mild Cognitive Impairment (MCI), which often leads to dementia. Currently, doctors use tests in clinics to check for these issues.
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer Disease, Healthy Aging
- Trial name
- NCT06367231
- Testing
- VibrantMinds
- Where
- 8 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Alzheimer Disease, Diabetes Mellitus, Type 2
Light and the Effect on Metabolic Syndrome and Alzheimer's Disease
This study's main hypothesis is that a delivering a tailored lighting intervention (TLI) will provide a successful means for promoting circadian entrainment and treating metabolic disease and inflammation in patients with mild…
- Trial name
- NCT03777722
- Testing
- Tailored Lighting Intervention
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obstructive Sleep Apnea, Mild Cognitive Impairment
Mild Cognitive Impairment and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) has been linked to increased risk for Alzheimer's disease (AD), but little prospective evidence exists on the effects of OSA treatment in preclinical AD.
- Trial name
- MEMORIES (NCT01482351)
- Testing
- CPAP adherence intervention, Attention control intervention
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- George Mason University
Dementia, Nursing Homes Residents
Sing Out Loud: A Choral Singing Program for Persons Living With Dementia
This study intends to investigate whether a singing programme for nursing home residents living with dementia can reduce the mental and physiological effects of dementia. The main questions it aims to answer are: 1.
- Trial name
- SOL (NCT06880237)
- Testing
- Singing
- Where
- Singapore
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Alzheimer's Disease, Aging
Do HMG CoA Reductase Inhibitors Affect Abeta Levels?
Recent evidence suggests that there is a significant overlap between AD and cerebrovascular disease. In fact, AD and cerebrovascular disease may share some of the same risk factors, including hypercholesterolemia.
- Trial name
- NCT00303277
- Testing
- simvastatin, pravastatin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Dementia
Multisensory Stimulation in Dementia.
Dementia is one of the main causes of disability in the elderly. It is characterized by cognitive, functional and social impairment, as well as behavioral changes.
- Trial name
- NCT04008342
- Testing
- Multisensory intervention
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
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