Clinical trials: Dementia Alzheimers
Dementia, Pain
Aggression Prevention Training for Caregivers of Persons With Dementia (APT)
This study will evaluate whether a home-based targeted education and skill training (Aggression Prevention Training or APT) will reduce aggression in persons with dementia (PWD) and pain/pain-related features more than usual care…
- Conditions
- Dementia, Pain, Alzheimer's Disease, Aggression
- Trial name
- APT (NCT02380703)
- Testing
- Aggression Prevention Training (APT), Enhanced Usual Primary Care (EU-PC)
- Volunteers
- 239 people
- Sponsor
- Baylor College of Medicine
Alzheimer Disease
REXULTI General Use Results Survey in Patients With Hyperactivity, or Aggressive Behavior Associated With Alzheimer's Dementia
The purpose of this study is to evaluate safety of REXULTI in patients under daily clinical settings. In addition, information on efficacy will be collected.
- Trial name
- NCT06875986
- Testing
- Brexpiprazole (Rexulti)
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Alzheimer Disease
Impact of Photobiomodulation (PBM) on Biomarkers of Alzheimer's Disease
Photobiomodulation (PBM) describes the use of near-infrared light (which is not visible to the eye) to heal and protect tissue that has either been injured, is degenerating, or else is at risk of dying.
- Trial name
- PBMbiomarker (NCT03405662)
- Testing
- Vielight Neuro Gamma
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Francisco
Dementia
Cognitive Behavioural Therapy of Early Dementia
A randomized, controlled, parallel-group trial to evaluate the efficacy of a cognitive behavioral therapy for patients with early dementia.
- Trial name
- KORDIAL (NCT00735046)
- Testing
- Cognitive behavioral therapy for early Alzheimer's disease, Control
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Alzheimer Disease, Dementia
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
The reason for this study is to assess the safety and efficacy of donanemab in participants with early Alzheimer's disease. The study duration including screening and follow-up is up to 93 weeks.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05508789
- Testing
- Donanemab
- Where
- 141 sites in Argentina, Australia and 6 more
- Volunteers
- 1,500 people
- Sponsor
- Eli Lilly and Company
Alzheimer Disease
Neurofeedback in Alzheimer's Disease
This study will evaluate behavioral and electrophysiological changes in a sample of adults with possible or probable Alzheimer's disease (AD), before and after undergoing training using a brain-computer interface (BCI) system…
- Trial name
- NCT03790774
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Agitation, Dementia
Life's End Benefits of cannaBidiol and tetrahYdrocannabinol
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks.
- Trial name
- LiBBY (NCT05644262)
- Testing
- T2:C100
- Where
- 10 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Alzheimer's Disease Psychosis
ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study
This 52-week, open-label extension study is to evaluate the long-term safety and tolerability of ACP-204 in subjects with ADP.
- Trial name
- NCT06194799
- Testing
- ACP-204
- Where
- 78 sites in United States, Brazil and 10 more
- Volunteers
- 752 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Anxiety Acute, Anxiety Fear
Paediatric Peri-operative Anxiety: Does the Little Journey App Help?
To evaluate the clinical effectiveness of a virtual reality psychological preparation app at reducing peri-operative anxiety and its associated sequelae in children aged 3-12 years old undergoing ambulatory surgery compared to…
- Conditions
- Anxiety Acute, Anxiety Fear, Peri-operative, Psychological Distress
- Trial name
- NCT03797716
- Testing
- Little Journey app
- Where
- 17 sites in United Kingdom
- Volunteers
- 596 people, healthy volunteers welcome
- Sponsor
- University College, London
Mild Cognitive Impairment (MCI), Dementia
An Insole and Ankle Device for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD)
This study tests an innovative system and service for collecting objective, consistent, and in-community gait parameters suitable for use as AD/ADRD biomarkers.
- Trial name
- NCT07127133
- Testing
- Insole and ankle device
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Alzheimer's Disease
Efficacy, Safety and Response Predictors of Astragalus Membranaceus on the Improvement of Cognitive Function in Mild-to-Moderate Alzheimer's Disease
Alzheimer's disease (AD), the most common cause of dementia, is characterized by cognitive impairment, mental and behavioural abnormalities, and social dysfunction.
- Trial name
- NCT05578443
- Testing
- 10g Astragalus, Routine treatment, 20g Astragalus
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fujian Medical University Union Hospital
Alzheimer's Disease
A Study to Test the Performance of the CogState Computerized Neuropsychological Battery in Patients With Alzheimer's Disease (0000-086)(COMPLETED)
This study will evaluate the performance of the CogState computerized neuropsychological battery, Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) and Alzheimer's Disease Cooperative Study - Activities of Daily…
- Trial name
- NCT00777608
- Testing
- Donepezil 5 - 10 mg, Donepezil 10 mg
- Volunteers
- 106 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease
The Diagnostic Cut-off Value of Core Biomarkers of Alzheimer's Disease
The participant in this study includes Alzheimer's disease (AD including familial AD and sporadic AD) patients, amnestic mild cognitive impairment (aMCI) patients, non-AD dementia patients and cognitively normal control.
- Trial name
- NCT05020106
- Where
- China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Alzheimer's Disease
Multiple Ascending Dose Study of TC-5619 in Healthy Elderly Subjects and Subjects With Alzheimer's Disease
This is a Phase 1 study to examine the safety, tolerability and pharmacokinetics of TC-5619 in elderly subjects with and without Alzheimer's disease.
- Trial name
- NCT01254448
- Testing
- TC-5619
- Where
- 10 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Functional Aging, Subjective Cognitive Concerns
A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
This intervention is designed to promote enhanced use of compensation strategies including calendar and task list use, and organization systems, as well as increased engagement with brain health activities including physical…
- Conditions
- Functional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health Activities
- Trial name
- NCT03549078
- Testing
- Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Metabolic Syndrome, Normal Cognition
Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
Background: In Alzheimer s disease (AD) the brain cannot use glucose as a fuel. The brain can use ketones as a fuel instead of glucose. Researchers want to test a supplement, Ketone Ester (KE).
- Trial name
- NCT04421014
- Testing
- Ketone Ester drink
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- National Institute on Aging (NIA)
Alzheimer Disease
A Study of the Effects on Sleep, Attention, and Gastrointestinal Tolerance of Galantamine and Donepezil in Patients With Alzheimer's Disease
The purpose of this study is to evaluate the relative effects of galantamine compared to donepezil (both cholinesteraste inhibitors), on sleep, attention, and gastrointestinal tolerance in patients with Alzheimer's disease.
- Trial name
- NCT00035204
- Testing
- galantamine
- Volunteers
- 63 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alzheimer's Disease
Observational Study to Monitor Long-term Immunogenicity and Efficacy of UB 311 Vaccine in Subjects With Alzheimer's Disease
The purpose of this observational study is to determine whether the vaccine (UB 311), targeting the N-terminal amino acids (1-14) of the amyloid beta peptide, has long-term immunogenicity and efficacy in individuals diagnosed…
- Trial name
- NCT01189084
- Testing
- Observational
- Where
- 2 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- United Biomedical
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