Clinical trials: Dementia Alzheimers
Alzheimer Disease
A Phase 1, Corplex™ Donepezil Transdermal System Compared to Oral Aricept®
A Phase 1, Randomized, Open-Label, 3-Way Crossover, Pilot, Pharmacokinetic Study to Evaluate the Steady State Pharmacokinetics of a Once-Weekly Application of Corplex Donepezil Transdermal Delivery System (TDS) Compared to Daily…
- Trial name
- NCT02968719
- Testing
- Donepezil TDS Version A, Donepezil TDS Version B, Aricept
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Genetic Health Risks
A Prospective, Monocentric Clinical Study for the Validation of in Vitro Diagnostic Tests Developed by Firalis
Firalis SA and its affiliate Amoneta Diagnostics SAS are developing novel in-vitro-diagnostic (IVD) tests for diverse diagnostic applications for major human diseases, including cardiovascular, and neurodegenerative disorders.
- Trial name
- ApoDiag (NCT06432192)
- Testing
- APO-Easy
- Where
- 2 sites in France
- Volunteers
- 1,474 people, healthy volunteers welcome
- Sponsor
- Firalis SA
Alzheimer Disease
Effects of Transcranial Direct Current Stimulation Associated With Cognitive Training in Alzheimer's Disease
Alzheimer's disease (AD) is characterized by a progressive decline in cognitive functions, interfering with autonomy and independence.
- Trial name
- NCT04220593
- Testing
- tDCS associated with Tcog
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Alzheimers Disease, AD
A Phase 0, Open Label, Multi-center Exploratory and Safety Study of [F-18]T807
[F-18]T807 is being developed as a diagnostic radiopharmaceutical for PET imaging of the human brain.
- Trial name
- NCT01733355
- Testing
- [F18] T807
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Alzheimer Disease
A Study of Oral EX039 in Subjects with Mild Alzheimer's Disease
This is a phase 2, randomized, double-blind, placebo-controlled study of oral EX039 as add-on to Acetylcholine Esterase Inhibitors in subjects with mild Alzheimer's disease.
- Trial name
- NCT05413655
- Testing
- EX039
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Excelsior
Alzheimer Disease
Effect of CAFfeine on Cognition in Alzheimer's Disease
Sporadic Alzheimer's disease is a multifactorial illness arising a major medico-economic stakes for our aging societies. There is currently no curative treatment available.
- Trial name
- CAFCA (NCT04570085)
- Testing
- Caffeine
- Where
- 17 sites in France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Lille
Transcranial Alternating Current Stimulation, Electroencephalography
Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease
To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease
- Conditions
- Transcranial Alternating Current Stimulation, Electroencephalography, Early Alzheimer's Disease
- Trial name
- NCT06565143
- Testing
- Transcranial alternating current stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Alzheimer Disease
German Registry of Alzheimer's Disease Treated With Transcranial Pulse Stimulation
This study will primarily investigate the safety and secondarily the effect and applicability of Transcranial Pulse Wave Stimulation (TPS) for the treatment of Alzheimer's disease in the context of a PMCF study (Post-Market…
- Trial name
- GE-R-A-TPS (NCT06313944)
- Testing
- Registry
- Where
- 6 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Alzheimer's Disease
Clinical Research Center for Dementia of South Korea (CREDOS)(or CRCD)
The objective of this study is to present evidence-based medicine for development of clinical practice guideline through prospective study of Alzheimer's disease(AD) and mild cognitive impairment(MCI) in korea
- Trial name
- CREDOS (NCT01198093)
- Where
- South Korea
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Alzheimer Disease, Parkinson Disease
Telephone Call From Acute Care Physicians to Long Term Care Physicians: Impact on Transitional Care of Elderly Patients
A telephone call from a physician taking care of a patient in the hospital to a physician in the long term care setting at the time of discharge can improve transitional care for elderly patients.
- Conditions
- Alzheimer Disease, Parkinson Disease, Dysphagia
- Trial name
- NCT00281749
- Testing
- TELEPHONE CALL
- Where
- 2 sites in United States
- Sponsor
- Maimonides Medical Center
Preclinical Alzheimer's Disease
Concurrent Aerobic Exercise and Virtual Reality Cognitive Training
The study will implement and test a unique Virtual Reality Cognitive Training (VRCT) combined with concurrent cycling on a recumbent stationary cycle, also known as exergame that seamlessly integrates specific cognitive tasks…
- Trial name
- VRCT (NCT02963415)
- Testing
- Exergame
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Minnesota
Alzheimer's Disease
Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease
Rosiglitazone (RSG) has been tested in clinical studies and is approved by the FDA as a treatment for type II diabetes mellitus, a disease that occurs when the body is unable to effectively use glucose.
- Trial name
- REFLECT-2 (NCT00348309)
- Testing
- Rosiglitazone Extended Release 2mg, Rosiglitazone Extended Release 8mg, Donepezil
- Where
- 249 sites in United States, Argentina and 17 more
- Volunteers
- 1,496 people
- Sponsor
- GlaxoSmithKline
Alzheimer's Disease
Acupressure as Long-term Intervention to Slow the Progression of Early/Mild Alzheimer's Disease
This is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early/mild AD will be recruited from care and attention homes for the elderly and elderly activity centers.
- Trial name
- NCT07779863
- Testing
- Comfy Acupressure for the Elderly, Least acupressure control
- Where
- Hong Kong
- Volunteers
- 188 people
- Sponsor
- The University of Hong Kong
Alzheimer's Disease
A Biomarker Study of Solanezumab in Patients With and Without Alzheimer's
The purpose of this trial is to compare the average change in the amount of amyloid beta species in blood after an infusion of solanezumab.
- Trial name
- NCT01148498
- Testing
- solanezumab
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alzheimer Disease
Study of Aripiprazole in the Treatment of Patients With Psychosis Associated With Dementia of the Alzheimer's Type
The purpose of this study is to learn if aripiprazole is safe and effective in the treatment of psychosis associated with dementia of the Alzheimer's type.
- Trial name
- NCT00036114
- Testing
- aripiprazole
- Where
- 41 sites in United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Alzheimer Dementia, Statins
Statins, Cholesterol and Cognitive Decline in Alzheimer's
Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or…
- Trial name
- NCT06635252
- Testing
- STA 4783
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Karolinska Institutet
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
Dementia, Alzheimers Disease
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
This phase 2a study will research the safety and tolerability of Foralumab, a human anti-CD3 antibody. An antibody is a molecule secreted by the immune system. These molecules are created to identify a specific pathogen.
- Conditions
- Dementia, Alzheimers Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
- Trial name
- NCT06489548
- Testing
- Foralumab TZLS-401 50 µg, Foralumab TZLS-401 100 µg
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease
Assessment the Efficacy of Acetyl-L-carnitine in Patient With Alzheimer's Disease
clinical trial to assess the efficacy of Acetyl-L-carnitine
- Trial name
- NCT02955706
- Testing
- Acetyl-L-Carnitine
- Where
- South Korea
- Volunteers
- 265 people
- Sponsor
- Dong-A ST Co., Ltd.
Dementia, Alzheimer Disease
A Study of the Effectiveness and Safety of Risperidone in the Treatment of Behavioral Disturbances in Patients With Dementia
The purpose of the study is to compare the effectiveness of an oral formulation of risperidone (an antipsychotic medication) to that of placebo for treating behavioral and psychological signs and symptoms in dementia (BPSSD)…
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT00249158
- Testing
- Risperidone
- Volunteers
- 344 people
- Sponsor
- Janssen-Cilag Pty Ltd
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