Clinical trials: Dementia Disorder
Frontotemporal Lobar Degeneration
DAPHNE Scale Validation in Frontotemporal Lobar Degeneration
Psycho-behavioral disorders assessment is crucial for the diagnosis and follow-up of patients with frontotemporal degeneration (FTD).
- Trial name
- DAPHNE (NCT02889601)
- Testing
- Psycho-behavioural assessment
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Nantes University Hospital
PTSD, Anger
Breaking the Cycle IV: Military PTSD (MPTSD) Treatment Study
The study will compare the efficacy of Trauma Affect Regulation: Guide for Education and Therapy (TARGET) vs. the best validated psychotherapy for adults with posttraumatic stress disorder (PTSD), Prolonged Exposure (PE).
- Conditions
- PTSD, Anger, Aggression
- Trial name
- MPTSD (NCT01228539)
- Testing
- TARGET (Trauma Affect Regulation), Prolonged Exposure
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- UConn Health
Alzheimer Disease
A Four Month Home Based tDCS Study on Patients With Alzheimer's Disease.
The study is an open label study on patients with Alzheimer's dementia using home based transcranial direct current (tDCS) stimulation. Aims of the study is to investigate applicability and effect of treatment.
- Trial name
- tDCS (NCT04759092)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- University Hospital of North Norway
Alzheimer Disease, Mild Cognitive Impairment
BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers
This research study aims to examine biomarkers of Alzheimer's disease as early as possible which could potentially be a screening tool for the general population.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT05457998
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948 Injection, [18F]-MK-6240 Injection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Alzheimer Disease, Oxidative Stress
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease
High lipid peroxidation and altered antioxidant defenses have been frequently reported in Alzheimer's disease patients. The purpose of this study is to investigate susceptibility to photo-oxidation of isolated erythrocyte…
- Conditions
- Alzheimer Disease, Oxidative Stress, Adrenocortical Hyperfunction
- Trial name
- NCT01707719
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raffaele Antonelli Incalzi
Amyloid, Amyloidosis
Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease
The purpose of this study is to test the safety and efficacy of Selinexor and Dexamethasone and see what effects it has on AL amyloidosis.
- Conditions
- Amyloid, Amyloidosis, AL Amyloidosis
- Trial name
- STARR (NCT04984330)
- Testing
- Selinexor, Dexamethasone
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Lewy Body Disease
Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood.
- Trial name
- DYNAPATH-LB (NCT07335692)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Alzheimer's Disease
An Observational Study of LEQEMBI in Routine Clinical Practice in Taiwan
The primary purpose of this study is to describe the incidence and severity of known adverse events, including amyloid-related imaging abnormalities (ARIA)-oedema/effusion (ARIA-E), ARIA-microhemorrhage and haemosiderin deposit…
- Trial name
- NCT07869264
- Testing
- No Intervention
- Where
- 12 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Eisai Taiwan Inc.
Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease
- Trial name
- MINDSET 1 (NCT06976216)
- Testing
- KarXT, KarX-EC
- Where
- 119 sites in United States, Argentina and 17 more
- Volunteers
- 586 people
- Sponsor
- Bristol-Myers Squibb
Creutzfeldt-Jakob Disease (CJD)
A Natural History Study of Preclinical Genetic Creutzfeldt-Jakob Disease (CJD)
Creutzfeldt-Jakob Disease (CJD) is the most common prion disease in humans causing a rapidly progressive neurological decline and dementia and is invariably fatal.
- Trial name
- NHS_CJD (NCT05746715)
- Where
- Israel
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Lewy Body Dementia With Behavioral Disturbance, Lewy Body Parkinson Disease
Telehealth in Lewy Body Dementia
Lewy body dementia (LBD) is the 2nd most common neurodegenerative dementia in the US. Optimal care requires an interdisciplinary approach, however often faced barriers include rural residence, limited access to specialists…
- Conditions
- Lewy Body Dementia With Behavioral Disturbance, Lewy Body Parkinson Disease, Lewy Body Disease
- Trial name
- NCT05014971
- Testing
- Tele-neurohub
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease
Assess 123-I IMPY and SPECT Imaging as a Tool to Detect β-Amyloid in the Brain
This research is designed to obtain efficacy and safety information for 123-I IMPY as an imaging biomarker for Alzheimer's disease (AD).
- Trial name
- NCT00287248
- Testing
- [123I] IMPY & SPECT Imaging
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Dementia With Vitamin B12 Deficiency
The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia.
Patients who fit the inclusion criteria are admitted into the study. They are given 3 IV injection of MBL in the first week and one tablet three times a day for 16 weeks.
- Trial name
- NCT00165711
- Testing
- Mecobalamin
- Where
- China
- Sponsor
- Eisai Co., Ltd.
Alzheimer Disease
Assessment of Sleep Disturbance in Alzheimer Disease
The purpose of this study is to study circadian rhythms, or daily cycles of sleep, wake, and activity. The investigators hope to learn how disturbed sleep in Alzheimer's Disease relates to changes in activity cycles, and how…
- Trial name
- NCT00831298
- Testing
- Analysis of sleep disturbance
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Caregivers
Life Enhancing Activities for Family Caregivers (LEAF 2.0)
The goal of the proposed intervention, called LEAF (Life Enhancing Activities for Family Caregivers) is to reduce burden and increase well-being in Alzheimer's Disease caregivers through the practice of positive emotion skills.
- Trial name
- NCT03610698
- Testing
- LEAF Positive Emotion Intervention, Emotion Reporting Control Condition
- Where
- United States
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alzheimer Disease
Autologous Activated Adipose-derived Stem Cells (RB-ADSC) Injected Directly Into the Brain for Mild to Moderate Alzheimer's Disease
This is a research study to evaluate the safety of an investigational autologous cell product obtained from participant's own adipose tissue as a possible treatment for Alzheimer disease.
- Trial name
- NCT05667649
- Testing
- RB-ADSC
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Regeneration Biomedical, Inc.
Alzheimer s Disease, Dementia
Usefulness of a Virtual Response Test as a Predictor of Functional and Cognitive Abilities in Older Adults With Different Degrees of Cognitive Impairment: a Pilot Study (ReactVR)
1. BACKGROUND Population aging is one of the most significant trends of the 21st century.In 2020, 21% of the European population was 65 years of age or older, compared to 16% in 2001.Today, 1 in 9 people is over 60, but it is…
- Conditions
- Alzheimer s Disease, Dementia, Virtual Reality, Virtual Reality Cognitive Training
- Trial name
- ReactVR (NCT07620509)
- Testing
- Virtual reality reaction time test
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Vigo
Mild Cognitive Impairment, Alzheimer Disease
Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)
This multi-site study will be the first to evaluate the dose-dependent effects of t-PBM in amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD) (CDR of 0.5-1, FAST 1-4; age 65-85) in a randomized clinical…
- Trial name
- NCT04784416
- Testing
- Active tPBM-2.0, 18F-MK-6240
- Where
- 3 sites in United States
- Volunteers
- 196 people
- Sponsor
- NYU Langone Health
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