Clinical trials: Dementia Mild
Alzheimer Disease
Transcranial Alternating Current Stimulation Combined With 40Hz Sound Stimulation for Treatment Alzheimer's Disease
Alzheimer's disease is characterized by progressive cognitive decline, and cognition is associated with cerebral concussion. Previous studies have found reduced gamma energy in the brain of AD patients.
- Trial name
- NCT05251649
- Testing
- tACS combined with 40 Hz sound stimulation, Transcranial alternating current stimulation, 40 Hz sound stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Cognitive Impairment, Dementia, Mild
Cognitive Screening Made Easy for PCPs - R33 Phase
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Dementia, Mild, Cognitive Decline
- Trial name
- NCT06162026
- Testing
- RACS app
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Texas at Austin
Mild Cognitive Impairment, Dementia
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies.
- Conditions
- Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
- Trial name
- NCT05235113
- Testing
- Tele-Exergame Platform, No Tele-Exergame Platform
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Alzheimer Dementia, Alzheimer Disease
Treating Hyperexcitability in AD With Levetiracetam
The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive Impairment
- Trial name
- LeAD (NCT03875638)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Mild Cognitive Impairment, Probable Alzheimer's Disease
Dietary Treatments for Cognitive Impairment in Older Adults
This trial seeks to establish the feasibility of implementing a ketogenic, modified Atkins diet (MAD) to older adults with mild cognitive impairment (MCI) or early Alzheimer's disease (AD) living in the community.
- Trial name
- NCT02521818
- Testing
- Modified Atkins Diet, NIA Diet for Seniors
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease
A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia
The main purpose of this study is to evaluate the safety and the effect on brain tau of the study drug LY3202626 in participants with mild Alzheimer's disease (AD) dementia.
- Trial name
- NAVIGATE-AD (NCT02791191)
- Testing
- LY3202626
- Where
- 76 sites in United States, Australia and 2 more
- Volunteers
- 316 people
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment, Dementia
Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial
The main purpose of this study is to build upon the evidence captured in the Imaging Dementia - Evidence for Amyloid Scanning (IDEAS; NCT02420756) trial to include valuable information regarding patient-reported outcomes and…
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer's Disease
- Trial name
- IMPACT2 (NCT02781220)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Utah
Mild Cognitive Impairment, Alzheimer Disease
Safety and Immunogenicity of Repeated Doses of ABvac40 in Patients With a-MCI or Vm-AD
Alzheimer's disease (AD) is the most common type of dementia, accounting for 50-75% of the estimated 47 million people with dementia worldwide.
- Trial name
- NCT03461276
- Testing
- ABvac40
- Where
- 23 sites in France, Italy and 2 more
- Volunteers
- 134 people
- Sponsor
- Araclon Biotech S.L.
Mild Cognitive Impairment, Dementia
Implications for Management of PET Amyloid Classification Technology
The main purpose of this study is to explore the impact of an amyloid positron emission tomography and computed tomography (PET/CT) scan on physician diagnosis and management, including drug management and care practices, for…
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer's Disease
- Trial name
- IMPACT (NCT02778971)
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Utah
MCI, MCI Conversion to Dementia
Neurocognitive Assessment Platform 4 Alzheimer
The aging population in Europe is leading to an increase in neurodegenerative diseases, such as Alzheimer's disease (AD), which is expected to affect 152 million people worldwide by 2050.
- Conditions
- MCI, MCI Conversion to Dementia, AMCI - Amnestic Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NAP4A2020 (NCT07272811)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Mild Cognitive Impairment, Alzheimer Disease
Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2
To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Type2 Diabetes
- Trial name
- NCT03933696
- Testing
- Tailored Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline.
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD)
- Trial name
- NCT07289061
- Testing
- Positive Psychology Intervention, Treatment as usual (TAU)
- Where
- Greece
- Volunteers
- 128 people
- Sponsor
- Aristotle University Of Thessaloniki
Alzheimer Disease, Cognitive Impairment
Safety, Efficacy and Dose Titration of Sodium Oligo-mannurarate Capsule on Mild to Moderate Alzheimer's Disease
The primary purpose of this study is to determine whether sodium oligo-mannurarate capsule is effective and safe in the treatment of mild to moderate alzheimer' disease, and to determine the best therapeutic dose of sodium…
- Trial name
- NCT01453569
- Testing
- Sodium oligo-mannurarate 600mg, Sodium oligo-mannurarate 900mg
- Where
- 24 sites in China
- Volunteers
- 255 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Alzheimer Disease, Dementia
Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease
This is a 24-month, monocentric, exploratory and observational clinical study aimed at developing and validating a blood-based diagnostic test for Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Disorders, Cognitive Decline
- Trial name
- ADKIT (NCT07294586)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Alzheimer Disease, Mild Cognitive Impairment
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognitive Decline
- Trial name
- QUIP II (NCT06025877)
- Testing
- PrecivityAD2(TM) blood test
- Where
- 9 sites in United States
- Volunteers
- 400 people
- Sponsor
- C2N Diagnostics
Cognition Disorder, Nervous System Diseases
A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
The purpose of this follow-up study is to assess the long-term safety and tolerability of galantamine in individuals with mild cognitive impairment who participated in a previous study with galantamine
- Conditions
- Cognition Disorder, Nervous System Diseases, Mental Disorders, Brain Diseases
- Trial name
- NCT00240695
- Testing
- galantamine hydrobromide
- Volunteers
- 724 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alzheimer Disease
Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
This randomized, double-blind, placebo-controlled, parallel group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early (prodromal to mild) AD.
- Trial name
- NCT03443973
- Testing
- Gantenerumab
- Where
- 155 sites in United States, Argentina and 17 more
- Volunteers
- 975 people
- Sponsor
- Hoffmann-La Roche
Dementia, Mild Cognitive Impairment
Promoting Activity, Independence and Stability in Early Dementia and Mild Cognitive Impairment
A clinical trial to test the clinical and cost-effectiveness of a therapy intervention designed to promote activity and independence and reduce falls, amongst people with early dementia or mild cognitive impairment
- Trial name
- PrAISED2 (NCT04065854)
- Testing
- Intervention
- Where
- 4 sites in United Kingdom
- Volunteers
- 368 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Alzheimer Disease
Efficacy and Safety of NVP-NK4146 in Patients With Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
The purpose of this clinical trial is to exploratively evaluate the efficacy and safety of NVP -NK4146 in improving mild cognitive impairment (MCI) in patients with due to Alzheimer's disease (AD) compared to placebo
- Trial name
- NCT06761066
- Testing
- NVP-NK4146
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- NVP Healthcare
Osteoarthritis, Knee, Dementia
Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia
This is the first study to test the effect of Tai Chi on pain from knee osteoarthritis in community-dwelling elders with mild cognitive impairment.
- Trial name
- NCT01528566
- Testing
- Tai Chi, Attention control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Arkansas