Clinical trials: Dementia Moderate, open to volunteers
Alzheimer Disease
Allogeneic Adipose Tissue Derived-stem Cells in Alzheimer Disease
A3D is a phase I/II clinical trial. The primary objective is to evaluate the safety of allogeneic adipose tissue derived-stem cells (AdMSC) administered by intravenous (IV) route in mild to moderate Alzheimer disease (AD) using a…
- Trial name
- A3D (NCT07367815)
- Testing
- CellREADY® drug product IV dose of 50 millions, CellREADY® drug product IV dose of 100 millions, cerebral RMI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease, Lewy Body Dementia (LBD)
Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients
This clinical trial aims to evaluate the clinical efficacy and safety of Deep Cervical Lymphaticovenous Anastomosis (DLVA) in patients aged 50-80 with moderate to severe neurodegenerative dementia.
- Conditions
- Alzheimer Disease, Lewy Body Dementia (LBD), Frontotemporal Dementia (FTD), Dementia
- Trial name
- NCT06978946
- Testing
- Deep Cervical Lymphaticovenous Anastomosis(DLVA)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- RenJi Hospital
Alzheimer Disease
BnH-015B Clinical Trial in Moderate Alzheimer's Disease
BnH-015B is a small molecule compound that targets the GluN2B binding site on NMDA receptors and positively modulates. BnH-015B has shown, through nonclinical trials, to improve symptoms of cognitive decline by regulating the…
- Trial name
- NCT06535308
- Testing
- BnH-015B 5 mg, BnH-015B 10 mg, BnH-015B 20 mg
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- BnH Research
Alzheimer Disease
Efficacy of RGn600 in Patients With Mild-to-moderate Alzheimer's Disease
This is a controlled investigation, with randomization of the patients, which aims at demonstrating the efficacy of device RGn600 in treating patients with mild-to-moderate Alzheimer's disease (AD).
- Trial name
- LIGHT4LIFE (NCT05926011)
- Testing
- RGn600
- Where
- 7 sites in France
- Volunteers
- 108 people
- Sponsor
- REGEnLIFE SAS
Type 2 Diabetes
The Effect of Exercise on the Brain in Type 2 Diabetes
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients.
- Trial name
- SAINT (NCT06734546)
- Testing
- Exercise intervention
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Hasselt University
Memory Disorders, Mild Cognitive Impairment
A Mobile Informatics Solution to Assist Caregivers in Care Coordination and Monitoring Social Engagement
This study will evaluate the Social Reminder System, a mobile informatics system designed to support persons with memory concerns and their care partners.
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Dementia, Social Isolation
- Trial name
- NCT07773493
- Testing
- Social Reminder System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Minnesota
Alzheimer s Disease
Effects of X Box Kinect 360 in Alzheimer's Disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia that accounting for 60% to 80% of all cases (Better, et al., 2023).
- Trial name
- AD Alzheimer' (NCT07673263)
- Testing
- 3D Kinect based game, Conventional therapy group
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Ziauddin University
Alzheimer's Disease
Deep Cervical Lymphovenous Anastomosis for Moderate Alzheimer's Disease
This is a multicenter, prospective, open-label, endpoint-blinded randomized controlled clinical study. We aim to evaluate the safety and efficacy of deep cervical lymphovenous anastomosis (LVA) combined with routine treatment for…
- Trial name
- LYMVA-AD (NCT07658430)
- Testing
- Deep cervical lymphovenous anastomosis (LVA), Routine Treatment
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Southwest Hospital, China
Pain, Dementia, Mild
Pain With Dementia
The purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver.
- Conditions
- Pain, Dementia, Mild, Dementia, Moderate
- Trial name
- PWD (NCT06854718)
- Testing
- Caregiver-Assisted Pain Coping Skills Training (CG-PCST)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer's Disease
An Efficacy and Safety Study of Sodium Oligomannate (GV-971) for the Treatment of Alzheimer's Disease
The primary purpose of this study is to confirm the clinical efficacy and mechanism of action of GV-971, and identify incidence of known adverse reactions in long-term use and observe new adverse reactions, providing more…
- Trial name
- NCT05908695
- Testing
- GV-971
- Where
- 50 sites in China
- Volunteers
- 1,312 people
- Sponsor
- Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
Alzheimer Disease (AD)
Study of Neural Stem Cell-Derived Exosomes in Moderate-to-Severe Early-Onset Alzheimer's Disease
This is an open-label, single-center, phase I clinical study in patients with moderate-to-severe early-onset Alzheimer's disease.
- Trial name
- NCT07554872
- Testing
- Neural Stem Cell-Derived Exosomes
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Mental Health Center
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Dementia
Dyadic Personalized Home-Based Activity Program for Mild-to-Moderate Dementia Patients Post-Discharge
This interventional study aims to evaluate the efficacy of a dyadic personalized home-based activity program in managing behavioral and psychological symptoms of dementia (BPSD) among home-dwelling people living with…
- Trial name
- NCT07081750
- Testing
- Dyadic personalized home-based activity program intervention, Routine care
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Fujian Medical University
Alzheimer Disease
A Phase 3 Study of Rotigotine in Combination with Rivastigmine in Mild to Moderate Alzheimer's Disease
This is a 24-week prospective, randomized, double-blind, placebo-controlled, multi-center phase III study evaluating efficacy and safety of rotigotine 4mg/24 hrs in combination with rivastigmine 9.5 mg/24 hrs in mild to moderate…
- Trial name
- DOPAD-3 (NCT06702124)
- Testing
- Rotigotine 4Mg/24Hrs Patch
- Where
- Italy
- Volunteers
- 348 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Moderate to Severe Alzheimer's Disease
GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD)
The objective of this study is to evaluate the safety and efficacy of GV1001 administered subcutaneously in patients with moderate to severe Alzheimer's disease (AD).
- Trial name
- NCT05303701
- Testing
- GV1001 1.12mg
- Volunteers
- 750 people
- Sponsor
- Samsung Pharmaceutical Co., Ltd.
Mild Dementia, Moderate Dementia
SHARE Adaptation Intervention for African-American Families
This project aims to culturally adapt the SHARE program for African-Americans in early-moderate stage dementia and their care partner.
- Trial name
- SHARE (NCT07208162)
- Testing
- 5+1 Adapted, early-stage dyadic care planning intervention, Counseling session and printed resources
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Benjamin Rose Institute on Aging
Alzheimer Disease
Study of Intracerebroventricular Injections of Autologous Adipose-Derived Stem Cells (RB-ADSCs) in Participants With Mild-Moderate Alzheimer's Disease
The goal of this Phase 2 clinical trial is to learn if repeated dosing of RB-ADSC (an investigational autologous cell product obtained from participant's own adipose tissue) enhances the positive preliminary results seen in Phase…
- Trial name
- NCT07205601
- Testing
- RB-ADSC
- Volunteers
- 115 people
- Sponsor
- Regeneration Biomedical, Inc.
Traumatic Brain Injury, Mild Traumatic Brain Injury
Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate
- Trial name
- NCT05048966
- Testing
- Group Wellness Class 1, Group Wellness Class 2
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kessler Foundation
Alzheimer's Disease
Evaluation of NBI-1117567 in Participants With Mild to Moderate Alzheimer's Disease (AD) Taking a Background Acetylcholinesterase Inhibitor
This study is designed to evaluate the efficacy on improving cognitive performance as well as the safety, tolerability, and pharmacokinetics (PK) of NBI-1117567 administered once daily (QD) in adults with mild to moderate AD who…
- Trial name
- NCT07832383
- Testing
- NBI-1117567
- Volunteers
- 135 people
- Sponsor
- Neurocrine Biosciences
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra