Clinical trials: Demoralization, open to volunteers
Demoralization
Pragmatic Trial of Psilocybin Therapy in Palliative Care
This multicenter, triple-blind, phase 2, randomized controlled trial will evaluate the efficacy and safety of psilocybin therapy compared to an active control in treating demoralization in adults near the end of life (≤2 years…
- Trial name
- PT2PC (NCT05403086)
- Testing
- Psilocybin, Ketamine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Charles S. Grob, M.D.
Advanced Cancer, Demoralization
A Feasibility Study of a Digitally-enabled Psychological Intervention for Demoralization in Advanced Cancer Patients
Advanced cancer is a leading cause of death worldwide and in China. Cancer patients often face reduced independence and self-care abilities, which may lead to psychological disturbances such as helplessness, hopelessness, or…
- Conditions
- Advanced Cancer, Demoralization, Psychological Intervention
- Trial name
- NCT07872254
- Testing
- A digitally-enabled positive psychological intervention for demoralization in advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Advanced Cancer, Various, NOS
Existential Distress in Advanced Cancer: Comparing a Short-term Psychodynamic Psychotherapy (ORPHYS) to Treatment as Usual (TAU)
The psychological challenges faced by patients with incurable cancer and their caregivers include an uncertain future, fear of dying and uncontrollable suffering, grief, and loneliness.
- Trial name
- NCT07312760
- Testing
- ORPHYS (ShORt-term psychodynamic psychotherapy in serious PHYSical illness), TAU (Treatment As Usual: Standard psycho-oncological care)
- Where
- 3 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Palliative Care, Pain
Lysergic Acid Diethylamide (LSD) in Palliative Care
Background: Terminally ill patients often experience significant psychosocial distress having depressed mood, death anxiety, pain, and an overall poor quality of life.
- Conditions
- Palliative Care, Pain, Anxiety, Depression
- Trial name
- LPC (NCT05883540)
- Testing
- Lysergic Acid Diethylamide Tartrate
- Where
- 4 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Demoralization, Safety
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage Cancer
Demoralization syndrome is frequently present in palliative care and oncology patients. In particular, up to a third of patients diagnosed with cancer will experience demoralization due to their illness.
- Trial name
- NCT06818994
- Testing
- Psilocybin-assisted Psychotherapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Gustavo Vazquez
Advanced Cancer, Demoralization
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
This pilot clinical trial will study psilocybin-assisted therapy for adults with advanced cancer who are experiencing demoralization, existential distress, or related psychological concerns.
- Conditions
- Advanced Cancer, Demoralization, Existential Distress, Psychological Distress
- Trial name
- PAT-MIND (NCT07791901)
- Testing
- PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary