Clinical trials: Demoralization
Depression
Treatment of Depression in Acute Coronary Syndrome (ACS) Patients
Emotional states of depression in association with ischemic heart diseases, such as myocardial infarction or unstable angina, are risk factors for subsequent cardiac events and mortality.
- Trial name
- TREATED-ACS (NCT00998400)
- Testing
- CBT in combination with WBT and life style modification
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
Demoralization
Demoralization Among Palliative Care Patients and Their Family Caregivers in Hong Kong: A Pilot Study
This study aims to explore the prevalence of demoralization among palliative care patients and family caregivers in Hong Kong and examines psychosocial factors associated with demoralization.
- Trial name
- NCT04006327
- Testing
- No intervention will be provided as this study is a cross-sectional observational study.
- Where
- Hong Kong
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Pancreatic Ductal Adenocarcinoma, Pain, Acute
Ketamine-assisted Therapy for Advanced GI Cancer
This clinical trial evaluates whether it is possible to use a single dose of ketamine in combination with talk therapy to treat moderate to severe demoralization in patients with stage 3 or 4 gastrointestinal (GI) cancers who…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pain, Acute, Gastrointestinal Cancers, Demoralization
- Trial name
- NCT06077487
- Testing
- Ketamine, Ketamine Injectable Product, Meaning and Purpose therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brian Anderson, MD
Malignant Neoplasm, Carcinoma
Short-term Psychodynamic Psychotherapy in Serious Physical Illness
Life-threatening physical illness may powerfully re-activate existential conflict. There is little evidence to date on the effectiveness of relationship-focused therapies in this patient group.The aim of this study is to pilot a…
- Conditions
- Malignant Neoplasm, Carcinoma, Palliative Care
- Trial name
- ORPHYS (NCT05520281)
- Testing
- Short-term psychodynamic psychotherapy for patients with serious physical illness (ORPHYS)
- Where
- 4 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
End of Life Patients
The Effectiveness of Dignity Therapy in Terminal Ill Patients
Maintaining patient dignity is the moral obligation and an important ethical consideration of health professionals; it is also the primary connotation of medical care.
- Trial name
- NCT07150728
- Testing
- dignity therapy, Hospice palliative care
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Emotional Stress, Psychological Distress
Dignity Therapy for Terminally Ill Patients: A Randomized Controlled Trial
We conducted a randomized, controlled trial of dignity therapy for terminally ill patients with the aim of reducing dignity-related distress and demoralization and improving spiritual well-being.
- Conditions
- Emotional Stress, Psychological Distress, Death, Dignity
- Trial name
- NCT04256239
- Testing
- Dignity Therapy
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- European University of Rome
Obesity
Promoting Weight Loss and Psychological Well-being in Obese Patients
The goal of the proposed research is to assess the effects of a sequential combination of lifestyle and well-being intervention on weight loss and psychological well-being.
- Trial name
- NCT03962205
- Testing
- cognitive-behavioral life style intervention, wellbeing intervention, treatment as usual
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- University of Bologna
Advanced Cancer, Demoralization
A Feasibility Study of a Digitally-enabled Psychological Intervention for Demoralization in Advanced Cancer Patients
Advanced cancer is a leading cause of death worldwide and in China. Cancer patients often face reduced independence and self-care abilities, which may lead to psychological disturbances such as helplessness, hopelessness, or…
- Conditions
- Advanced Cancer, Demoralization, Psychological Intervention
- Trial name
- NCT07872254
- Testing
- A digitally-enabled positive psychological intervention for demoralization in advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Post-stroke Depression
To Investigate the Correlation of Stroke Patients and Demoralized
This study aim to clarify the participants's mental state with Demoralization Scale- Mandarin Version(DS-MV). Based on clinical observations and literature review, investigators assume participants's DS-MV score high correlation…
- Trial name
- NCT03829397
- Testing
- Questionnaire
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taoyuan General Hospital
Hospice, Psilocybin
Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care
The overall objective of this study is to develop and pilot test a novel regimen of psilocybin-assisted psychotherapy for demoralization in patients receiving hospice care.
- Conditions
- Hospice, Psilocybin, Demoralization, Terminal Illness
- Trial name
- PATH (NCT04950608)
- Testing
- Psilocybin, Psychotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yvan Beaussant, MD, MSci
Advanced Cancer, Various, NOS
Existential Distress in Advanced Cancer: Comparing a Short-term Psychodynamic Psychotherapy (ORPHYS) to Treatment as Usual (TAU)
The psychological challenges faced by patients with incurable cancer and their caregivers include an uncertain future, fear of dying and uncontrollable suffering, grief, and loneliness.
- Trial name
- NCT07312760
- Testing
- ORPHYS (ShORt-term psychodynamic psychotherapy in serious PHYSical illness), TAU (Treatment As Usual: Standard psycho-oncological care)
- Where
- 3 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Palliative Care, Pain
Lysergic Acid Diethylamide (LSD) in Palliative Care
Background: Terminally ill patients often experience significant psychosocial distress having depressed mood, death anxiety, pain, and an overall poor quality of life.
- Conditions
- Palliative Care, Pain, Anxiety, Depression
- Trial name
- LPC (NCT05883540)
- Testing
- Lysergic Acid Diethylamide Tartrate
- Where
- 4 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Demoralization
Pragmatic Trial of Psilocybin Therapy in Palliative Care
This multicenter, triple-blind, phase 2, randomized controlled trial will evaluate the efficacy and safety of psilocybin therapy compared to an active control in treating demoralization in adults near the end of life (≤2 years…
- Trial name
- PT2PC (NCT05403086)
- Testing
- Psilocybin, Ketamine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Charles S. Grob, M.D.
Prostatic Neoplasms, Self-Management
Effectiveness Evaluation of a Self-management Program for Prostate Cancer Survivors
Objectives: This project aims to develop a self-management program for survivors with prostate cancer experiencing urinary incontinence following radical prostatectomy and determine its effectiveness.
- Trial name
- NCT05335967
- Testing
- Self-management program, Information package
- Where
- 2 sites in Taiwan
- Volunteers
- 85 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Distress, Depression
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
The purpose of this study is to determine whether psilocybin-assisted group psychotherapy is a safe and feasible treatment for demoralization in long-term AIDS survivors (LTAS).
- Conditions
- Distress, Depression, Grief
- Trial name
- NCT02950467
- Testing
- Psilocybin, Modified brief Supportive Expressive Group Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua Woolley
Advanced Cancer, Demoralization
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
This pilot clinical trial will study psilocybin-assisted therapy for adults with advanced cancer who are experiencing demoralization, existential distress, or related psychological concerns.
- Conditions
- Advanced Cancer, Demoralization, Existential Distress, Psychological Distress
- Trial name
- PAT-MIND (NCT07791901)
- Testing
- PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Demoralization
Effects of a Five-Dimensional Intervention Program Based on Inner Strength on Demoralization Syndrome in Elderly Cancer Patients
From January 2025 to January 2026, a total of 66 elderly cancer patients with demoralization syndrome who were hospitalized in the Department of Internal Medicine at Peking Union Medical College Hospital were enrolled.
- Trial name
- NCT07625904
- Testing
- psychological support
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Demoralization
Spiritual Well-being, Self-compassion, Physical Symptoms Distress and Demoralization Among HD Patients
To explore the associations between spiritual well-being, self-compassion, physical symptoms distress and demoralization among hemodialysis patients
- Trial name
- NCT05841459
- Where
- Taiwan
- Volunteers
- 156 people
- Sponsor
- Chang Gung University of Science and Technology
Neoplasms Malignant, Carcinoma
Existential Distress in Patients with Advanced Cancer and Their Caregivers
Despite the potential for alleviation of existential distress through psychosocial interventions, existential concerns and their impact on health care outcomes of patients and caregivers have not yet been systematically studied.
- Conditions
- Neoplasms Malignant, Carcinoma, Palliative Care
- Trial name
- NCT04600206
- Testing
- Self-report questionnaires
- Where
- 5 sites in Germany
- Volunteers
- 800 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Tardive Dyskinesia
Reduction of Demoralization in Patients With Tardive Dyskinesia After Treatment With Valbenazine
This will be an Investigator-initiated pilot study in which participants will be assessed with various scales to measure demoralization, anxiety, depression, and subjective incompetence at baseline and every two weeks after…
- Trial name
- NCT05053321
- Testing
- Valbenazine
- Where
- United States
- Sponsor
- Yale University