Clinical trials: Demyelinating Autoimmune Diseases, CNS
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Multiple Sclerosis, Relapsing-Remitting
Efficacy Study of Andrographis Paniculata Purified Standardized Extract (ApE) in Patients With Multiple Sclerosis (MS)
To evaluate the efficacy of ApE coated tablets, on the relapse rate in a group of relapsing remitting multiple sclerosis (RRMS) patients, as compared to a placebo group in a period of 12 months.
- Trial name
- PCNS-EM (NCT02280876)
- Testing
- 1 - Andrographis paniculata p/st extract, 2 - Excipients
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad Austral de Chile
Multiple Sclerosis
Preventive Use of COrticosteroids During the Post-Partum in Relapsing MS Patients (COPP-MS)
Multiple Sclerosis (MS) is most prevalent among women of childbearing age. The post-partum (PP) period is a critical phase in MS patients, during which a recrudescence of disease activity is expected.
- Trial name
- COPP-MS (NCT03917589)
- Where
- 5 sites in France
- Volunteers
- 350 people
- Sponsor
- Rennes University Hospital
Spasticity, Multiple Sclerosis
A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosis
To explore the safety and efficacy of IPX056 compared with baclofen tablets for alleviation of symptoms of spasticity associated with multiple sclerosis (MS).
- Trial name
- NCT00914290
- Testing
- IPX056, Baclofen IR
- Where
- 11 sites in United States
- Volunteers
- 23 people
- Sponsor
- Impax Laboratories, LLC
Multiple Sclerosis
Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis
Multiple sclerosis (MS) is among the most prevalent autoimmune diseases among young and middle-aged adults. Up to 65% of MS patients experience objective cognitive impairment including problems with information processing speed…
- Trial name
- NCT03889327
- Testing
- Neuropsychological Feedback & Psychoeducation (Cognition), Psychoeducation (Health)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Missouri, Kansas City
Multiple Sclerosis
Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS
Imaginative Distention (ID) is proposed as supportive and integrative intervention to cope with fatigue, (principal end point), to cope with insomnia, stress perception and to improve QoL of pw MS, insomnia pw and health care…
- Trial name
- DIMMISI (NCT02290990)
- Testing
- "Imaginative Distention" technique
- Where
- Italy
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Relapsing Remitting Multiple Sclerosis
A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS
To establish a pharmacokinetic (PK) profile of BG00012, as measured by its primary metabolite, monomethyl fumarate (MMF), during a 24-hour dosing period in subjects with relapsing-remitting multiple sclerosis (RRMS), with a…
- Trial name
- NCT00837785
- Testing
- BG00012
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Biogen
Multiple Sclerosis, Relapsing-Remitting
Tecfidera and the Gut Microbiota
The primary objective of the study is to determine if dimethyl fumarate (DMF) causes changes in the abundance and diversity of commensal microbiota.
- Trial name
- TECONGUT (NCT02471560)
- Testing
- dimethyl fumarate, injectable MS DMT
- Where
- 7 sites in Norway
- Volunteers
- 36 people
- Sponsor
- Biogen
Multiple Sclerosis, Relapsing-Remitting
Investigation of the Effect of Dimethyl Fumarate on T Cells in Patients With Relapsing Remitting Multiple Sclerosis
This is an exploratory study, which allows analysis of multiple immune parameters derived from peripheral blood mononuclear cells (PBMCs) from patients with relapsing remitting multiple sclerosis before and during…
- Trial name
- DIMAT-MS (NCT02461069)
- Testing
- Dimethyl fumarate
- Where
- 6 sites in Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Multiple Sclerosis
Social and Moral Cognition in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic, progressive disease that affects young adults (aged between 20 and 40) and has a major impact on patients' quality of life. Cognitive disorders in MS are common, affecting 40-60% of patients.
- Trial name
- COSMOS (NCT06318923)
- Testing
- Socio-demographic questionnaire, moral judgment task, cognitive tests, psychoaffective assessment, MS questionnaire, MONTREAL COGNITIVE ASSESSMENT (MoCA) test
- Where
- 2 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Multiple Sclerosis
Study of the Mechanisms of Action of Cladribine in Multiple Sclerosis
The main objective of the project is therefore to study and thus better understand the immunomodulatory / anti-inflammatory effects of cladribine during multiple sclerosis.
- Trial name
- Clad'Action (NCT04821596)
- Testing
- biological collection
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Rouen
Multiple Sclerosis
Whole Body Vibration Therapy in a Participant With Multiple Sclerosis Related Balance Deficits - A Case Study
The purpose of this investigation is to determine the effect of Whole Body Vibration Therapy (WBV) on balance in a participant with multiple sclerosis (MS) related balance deficits as measured by the NeuroCom Balance Master, the…
- Trial name
- NCT00343590
- Testing
- Whole Body Vibration machine
- Where
- 2 sites in United States
- Sponsor
- Logan College of Chiropractic
Multiple Sclerosis, Pain
Multiple Sclerosis-Collaborative Approach to Rehabilitation Effectiveness Study
The purpose of this study is to: (1) test the benefits of the patient-centered collaborative care treatment approach for persons with MS who also have depression and/or pain; and also (2) test whether this approach improves…
- Conditions
- Multiple Sclerosis, Pain, Depression
- Trial name
- MS-CARE (NCT02137044)
- Testing
- Collaborative Care (CC)
- Where
- 3 sites in United States
- Volunteers
- 195 people
- Sponsor
- University of Washington
Multiple Sclerosis, Relapsing-Remitting
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun.
- Trial name
- TREAT-MS (NCT03500328)
- Testing
- Natalizumab/natalizumab-sztn, Alemtuzumab, Ocrelizumab, Rituximab/rituximab-arrx/rituximab-abbs/rituximab-pvvr, Cladribine, Ofatumumab, Ublituximab-xiiy, Ocrelizumab and hyaluronidase-ocsq, Glatiramer acetate, Interferons (intramuscular, subcutaneous, pegylated) Teriflunomide, Fumarates (dimethyl, diroximel, monomethyl) Fingolimod, Siponimod, Ozanimod, Ponesimod
- Where
- 47 sites in United States
- Volunteers
- 900 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study
This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults…
- Trial name
- MAPMyeMS (NCT07723599)
- Testing
- Observation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Washington
Multiple Sclerosis
Study on Cognitive Disorders of Multiple Sclerosis
The purpose of this study is to determine if memantine is effective in the treatment on cognitive disorders of Relapsing - Remitting multiple sclerosis. m
- Trial name
- NCT01074619
- Testing
- Memantine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Multiple Sclerosis
Accuracy of Motor Performance Perception in Multiple Sclerosis
The aim of this study is to characterize perceptive abilities in PwMS compared to controls when performing prolonged functional tasks such as walking and repeated standing from a seated position.
- Trial name
- NCT07175792
- Where
- 3 sites in Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis, Balance
Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal degeneration.
- Trial name
- NCT07648277
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Multiple Sclerosis
Repetitive Deep Transcranial Magnetic Stimulation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic-inflammatory autoimmune central nervous system disorder and a leading cause of neurological disability in younger adults in Western countries.
- Trial name
- rTMS in MS (NCT01106365)
- Testing
- H-coil (Repetitive deep transcranial magnetic stimulation)
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Transcutaneous Posterior Tibial Nerve Stimulation in Patients With Multiple Sclerosis Related Urge Incontinence
Recently, several studies have investigated the safety and efficacy of the Stoller afferent nerve stimulation (SANS) treatment in Multiple Sclerosis (MS) patients.
- Trial name
- SANS-REHAB (NCT06314412)
- Testing
- Stoller's Afferent Nerve Stimulation (SANS)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
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