Clinical trials: Demyelinating Autoimmune Diseases, CNS
Telerehabilitation
The Effect of Telerehabilitation on Balance in People With Multiple Sclerosis
The study will compare the effect of individual telerehabilitation with offline remote exercise through videos and with a control group without intervention.
- Trial name
- NCT05839977
- Testing
- Individual telerehabilitation, Home exercises based on videos
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Multiple Sclerosis
Costs, Quality of Life and Functional Outcomes in Veterans Treated for Multiple Sclerosis With Beta-Interferon l-B (Betaseron)
The treatment of multiple sclerosis was evolving in light of specific drug therapies to treat the disease, refinements and acceptance of imaging with MRI to diagnose and monitor the disease process, and progress in understanding…
- Trial name
- NCT00439257
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- US Department of Veterans Affairs
Multiple Sclerosis
Validation of the BeCare Multiple Sclerosis Assessment App
This study involves data collection from use of the BeCare Link LLC mobile device app by subjects with Multiple Sclerosis.
- Trial name
- NCT04288011
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- BeCare Link LLC
Multiple Sclerosis
Activity and Balanced Eating to Reduce Comorbidities and Symptoms of MS
Multiple sclerosis (MS) is the leading cause of irreversible neurological disability among young women and the second leading cause of disability among young men in the U.S.
- Trial name
- ABC's of MS (NCT03808545)
- Testing
- Behavioral Intervention for Physical Activity in Multiple Sclerosis (BIPAMS), BIPAMS + Diet
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Relapsing-remitting Multiple Sclerosis
Understanding the 'Durable Effect' Concept of B-cell Modulating Therapies
This prospective, observational clinical study aims to longitudinally assess peripheral immune cell profiles of patients with relapsing-remitting multiple sclerosis (RRMS) receiving anti-CD20 therapy with ofatumumab (OFA)…
- Trial name
- REBELLION-MS (NCT06586177)
- Testing
- Anti-CD20 antibody
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cognition Disorders, Multiple Sclerosis
A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis
The purpose of this study is to determine the safety and efficacy of C105 in treating the cognitive deficits that can occur due to multiple sclerosis.
- Trial name
- NCT00529581
- Testing
- C105
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Cognition Pharmaceuticals, LLC
Multiple Sclerosis, Dysphagia
Effects of CTAR and PNF Exercises on Swallowing in Multiple Sclerosis
This study compares two exercise programs for people with multiple sclerosis (MS) who have trouble swallowing. One group did chin exercises against resistance (CTAR), and the other group did neck exercises based on a technique…
- Conditions
- Multiple Sclerosis, Dysphagia, Deglutition Disorders
- Trial name
- CTAR-PNF-MS (NCT07726667)
- Testing
- CTAR exercise, PNF exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Sanko University
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Multiple Sclerosis
Effects of Low-intensity Interval Walking With Blood Flow Restriction on Functional Capacity in Multiple Sclerosis
The aim of the study is to evaluate the safety, feasibility and initial efficacy of an interval-based walking training at low speed performed with blood flow restriction (BFR) on gait speed and functional impairments in patients…
- Trial name
- NCT03544177
- Testing
- BFR-Walking, Conventional therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University Hospital of Ferrara
Parkinson Disease, Stroke
Smart Wearable Device (gaitQ): Walk Better Project
This study will be underpinned by the new MRC guidelines for developing a complex intervention with a participatory design methodology that uses evidence-based research and behaviour change models alongside COSMIN methodology for…
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis, Osteoporosis
- Trial name
- NCT05913219
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Multiple Sclerosis
Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Clinical and experimental evidences suggests an immunomodulatory effect of sex hormones in multiple sclerosis. The role of oral estroprogestins in the pathogenesis and in the clinical course of the disease is actually unknown.
- Trial name
- NCT00151801
- Testing
- estroprogestins, interferon-beta 1a
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- S. Andrea Hospital
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072001
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Multiple Sclerosis
Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)
Although the Blood Flow Restriction Training (BFRT) system has attracted the attention of health professionals, research on this tool in people with neurological pathology, particularly multiple sclerosis (MS), is very limited.
- Trial name
- BFRT-EM (NCT06795230)
- Testing
- Muscle strengthening (BFRT), Conventional physical therapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Rey Juan Carlos
Multiple Sclerosis (MS) - Relapsing-remitting
Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis
The purpose of the research study is to explore new retinal imaging biomarkers of immune cell activity in MS during use of ublituximab (Briumvi) treatment.
- Trial name
- NCT06864936
- Testing
- Ublituximab, Other disease modifying therapies
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Multiple Sclerosis, Dysuria
Efficacy of Alpha-blockers (Tamsulosin) in the Treatment of Symptomatic Dysuria in Multiple Sclerosis in Women
Multiple sclerosis (MS) is the leading non-traumatic cause of severe acquired disability in young people. The disease is defined by relapses, which can affect all neurological functions depending on the location of the new…
- Conditions
- Multiple Sclerosis, Dysuria, Lower Urinary Tract Symptoms, Voiding Dysfunction
- Trial name
- ALPHA-SEP (NCT05439902)
- Testing
- Tamsulosin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD)
A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
This is an investigator-initiated, single-center, open-label study of C-CAR168, an autologous bi-specific CAR-T therapy targeting CD20 and BCMA, for the treatment of adult patients with central nervous system autoimmune diseases…
- Conditions
- Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD), Autoimmune Encephalitis, Stiff Person Syndrome
- Trial name
- NCT07341828
- Testing
- CD20/BCMA-directed CAR-T cells
- Volunteers
- 15 people
- Sponsor
- Huashan Hospital
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Multiple Sclerosis
MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis
Multiple sclerosis (MS) is the first non-traumatic cause of disability in young people, responsible for physical but also cognitive deficits.
- Trial name
- SEP-MRI (NCT03356366)
- Testing
- MRI 3T, MRI 1,5T, MRI 7T
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression
To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.
- Trial name
- TERIPET (NCT03368677)
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Turku University Hospital
Rehabilitation
Changes in Physical Activity in All Day Life in People With MS Before and After Rehabilitation
The primary objective is to observe the impact of in-patient rehabilitation on physical activity in daily life using miniature, wearable sensors, fixed on the shoes. These sensors record data about various aspects of walking.
- Trial name
- NCT03769636
- Testing
- GaitUp Physilog 5
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Klinik Valens
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