Clinical trials: Demyelinating Disorder
Multiple Sclerosis
Digital Gait Analysis in the Home Environment of Patients With Multiple Sclerosis
The aim of this study is the development of novel telemedical examination methods based on sensor-based gait analysis in patients with multiple sclerosis (MS).
- Trial name
- MSgoesHome (NCT04771858)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical Valley Digital Health Application Center GmbH
Multiple Sclerosis
Applications of Nanotechnology in Multiple Sclerosis by Respiratory Samples
Multiple Sclerosis (MS) is a complex multi-factorial disease, with underlying both genetic and environmental factors. Different populations have different susceptibility.
- Trial name
- MS-NANOSE (NCT01206023)
- Testing
- NA-NOSE artificial olfactory system
- Where
- 2 sites in Israel
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Sclerosis, Multiple
Can Fatigability Neuromuscular Explain Chronic Fatigue in People With Multiple Sclerosis?
Chronic fatigue is the most common and debilitating symptom in multiple sclerosis patients. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life.
- Trial name
- FatSEP (NCT03983720)
- Testing
- Evaluation of degree chronic fatigue., Questionnaires, Blood sample
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Multiple Sclerosis
Resting Postural Tremor in Multiple Sclerosis
Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple…
- Trial name
- NCT04405479
- Testing
- Examination of tremor and upper hand functions
- Where
- 3 sites in Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Multiple Sclerosis, Exercise Therapy
Carnosine Loading and Periodized Training in MS and HC
Increasing evidence favours exercise therapy as an efficient tool to counteract inactivity related secondary symptoms in MS. Furthermore, exercise therapy may affect MS-associated muscle contractile and energy supply…
- Conditions
- Multiple Sclerosis, Exercise Therapy, Dietary Supplement
- Trial name
- NCT03418376
- Testing
- Beta-alanine supplementation, Exercise intervention
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial
The purpose of this trial is to evaluate the effects of Rebif® 44 mcg subcutaneous (sc) three times a week (tiw) on a) remyelination/demyelination, b) lesion and brain volume, c) central nervous system (CNS) iron deposition, and…
- Trial name
- NCT01085318
- Testing
- Rebif
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- EMD Serono
Multiple Sclerosis
Motor Imagery Training in Persons With Multiple Sclerosis
Motor imagery training facilitates the neural plasticity with increasing the neuronal cortical pathways in the brain. Motor imagery training is an effective way in stroke survivors.
- Trial name
- NCT02781142
- Testing
- Motor imagery training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Multiple Sclerosis
Investigating Indirect Mechanism of Neuroprotection of Tecfidera® (Dimethyl Fumarate) in RRMS and Progressive Patients
The purposes of this study is to identify types of bacteria that reside in the intestine of healthy individuals and compare them to individuals with Multiple Sclerosis (MS).
- Trial name
- NCT03092544
- Testing
- dimethyl fumarate
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Multiple Sclerosis Center of Northeastern New York
Multiple Sclerosis, Oxidative Stress
The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects
The purpose of this study is to investigate the gene expression and activity of SIRT1, and forkhead box O3 pathway by means of investigating target genes MnSOD and catalase in multiple sclerosis and healthy subjects.
- Trial name
- NCT02463318
- Testing
- Melatonin, Hydrogen peroxide
- Where
- Iran
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Acute Inflammatory Demyelinating Polyradiculoneuropathy, Stroke
Processing Integration in Neurological Patients Using fMRI
The main objective of the study is to explore and map brain areas involved in processing and perception in patients suffering from neurological pathologies and condition.
- Conditions
- Acute Inflammatory Demyelinating Polyradiculoneuropathy, Stroke, Anosognosia, Central and Peripheral Neurodegenerative Pathologies
- Trial name
- NCT02722070
- Testing
- 3 Tesla Siemens Skyra MRI scanner
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Multiple Sclerosis
Baseline Cortical Haemodynamics in MS
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease.
- Trial name
- CortHaem (NCT02481882)
- Testing
- Magnetic Resonance Imaging, Prohance (Gadoteridol)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
The Effect of Self-Acupressure Application on Functional Composite and Quality of Life in Multiple Sclerosis Patients
It is important to consider the functional composite and quality of life of patients with multiple sclerosis (MS) and to plan interventions for these problems.
- Trial name
- NCT04936555
- Testing
- Self-Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Sabahattin Zaim University
Multiple Sclerosis, Medical Device
Use of Inertial Units in Patient With Multiple Sclerosis (IMUSEP)
The goal of this case control study is to evaluate the use of inertial navigation systems to detect and characterize early locomotor disorders in patients with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Medical Device, Coordination and Balance Disturbances
- Trial name
- IMUSEP (NCT06634225)
- Testing
- Usual care (as recommended by the Haute Authorité de Santé (HAS)) and medical device test
- Where
- 2 sites in France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Multiple Sclerosis
Remote Evaluation in Patients With Multiple Sclerosis
This study aimed to demonstrate the remote reliability of the 30-second sit-to-stand test in patients with multiple sclerosis.
- Trial name
- NCT06308042
- Testing
- 30 second sit and stand test
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Inonu University
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis, 3D Gait Analysis
Gait Analysis in Multiple Sclerosis Patients
In the literature, the results of vestibular rehabilitation treatment applied in patients with Multiple Sclerosis (MS) have been investigated in detail under the headings such as fatigue, physical activity level, and quality of…
- Conditions
- Multiple Sclerosis, 3D Gait Analysis, Vestibular Rehabilitation
- Trial name
- NCT05299151
- Testing
- Vestibular exercises, Standard neurorehabilitation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Multiple Sclerosis
[18F]PBR111 and Microglial Activation in Multiple Sclerosis
This is a study aimed to characterize [18F]PBR111 as an in vivo marker of microglial activation in Multiple Sclerosis. Regional binding of [18F]PBR111 will be quantified with PET in the brain of up to 24 patients with multiple…
- Trial name
- NCT01428505
- Testing
- [18F]PBR111
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
Restoration of Walking in Multiple Sclerosis Using Treadmill Training.
The primary purpose of this study is to collect preliminary and pilot data to begin to determine whether the use of body weight support treadmill therapy (BWSTT) with and without driven-gait-orthotics (DGO), results in improved…
- Trial name
- NCT00156676
- Testing
- Body-weight supported treadmill, Lokomat
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Multiple Sclerosis, Cognitive Decline
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Trial name
- MSNEUROPLAST (NCT04806568)
- Testing
- Cognitive Training, Monitoring of daily activity
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Autoimmune Diseases, Multiple Sclerosis
First-in-Human Trial in Healthy Adult Volunteers to Evaluate Safety, Tolerability and PK of LAPIX Study Drug; LPX-TI641
A Phase I First-in-Human, Randomized, Double-Blind, Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate Safety, Tolerability, and Pharmacokinetics after Single and Multiple Oral Dose of LPX-TI641.
- Trial name
- NCT05853835
- Testing
- LPX-TI641
- Where
- 2 sites in United States, Jordan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- LAPIX Therapeutics Inc.