Clinical trials: Demyelinating Disorder
Relapsing-Remitting Multiple Sclerosis (RRMS)
Brimonidine Tartrate for the Treatment of Injection Related Erythema
The primary objective of this study is to evaluate the Injection Related Erythema (IRE) mitigation effect of a single administration of brimonidine tartrate in comparison with a vehicle gel (placebo).
- Trial name
- BRITE (NCT02568111)
- Testing
- peginterferon beta-1a, brimonidine tartrate, Vehicle Gel
- Sponsor
- Biogen
Relapsing Multiple Sclerosis (RMS)
Effects of Cladribine Tablets on the PK of Microgynon®
The purpose of this study was to investigate the potential effects of cladribine on the pharmacokinetics (PK) of monophasic oral contraceptive microgynon® by assessment of its constituents, ethinyl estradiol (EE) and…
- Trial name
- NCT03745144
- Testing
- Cladribine, Microgynon®
- Where
- 7 sites in Germany, Poland
- Volunteers
- 28 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis, Healthy Control
Trunk Restraint in Multiple Sclerosis
This study examined the effect of trunk restraint on upper extremity functionality in patients with Multiple Sclerosis (MS).The study included 66 MS patients over the age of 18 and 30 healthy individuals.
- Trial name
- NCT06982833
- Testing
- Trunk restraint
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
X-Linked Adrenoleukodystrophy, Adrenomyeloneuropathy
Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)
The purpose of this study is to assess the safety, tolerance, pharmacokinetics, and pharmacodynamics of sobetirome, a selective thyroid hormone analog, in adult male X-ALD patients.
- Trial name
- NCT01787578
- Testing
- Sobetirome
- Where
- United States
- Sponsor
- Thomas S. Scanlan
Progressive Multifocal Leukoencephalopathy
Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study
Background: Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal brain infection caused by the JC virus. The JC virus is common. More than half of adults have been exposed to it.
- Trial name
- NCT07511049
- Testing
- Brincidofovir
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis, Control Subjects
Deciphering Preserved Autonomic Function After Multiple Sclerosis
This study looks to characterize gradients of dysfunction in the autonomic nervous system in patients with clinically diagnosed multiple sclerosis.
- Conditions
- Multiple Sclerosis, Control Subjects, Autonomic Dysreflexia
- Trial name
- DPAF-MS (NCT07012135)
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Multiple Sclerosis
Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis
The objective of this study is to evaluate the efficacy of L-carnitine versus placebo in the treatment of fatigue in multiple sclerosis patients. This study will randomize 60 patients in a cross-over design.
- Trial name
- FACTSEP (NCT01149525)
- Testing
- L-Carnitine
- Where
- 6 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Bordeaux
Relapsing Remitting Multiple Sclerosis
Long-term Effect of Fingolimod on Circulating Immunocompetent Mononuclear Cells in Patients With Multiple Sclerosis
The purpose of this study is to explore immunomodulatory and immunosuppressive mechanisms of action of fingolimod in patients with Relapsing remitting multiple Sclerosis to collect data on biomarkers after initiation of…
- Trial name
- BiobankII (NCT01755871)
- Testing
- Fingolimod
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD)
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
This study is an open-label, exploratory, prospective clinical trial with dose escalation(according to "3+3" design), to evaluate the safety and tolerability of QH103(Universal CD19 CAR-γδT Cell Injection)in the treatment of…
- Conditions
- Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD), Autoimmune Encephalitis (AE), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Trial name
- NCT07526493
- Testing
- Universal CD19 CAR-γδT Cell Injection, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Tongji Hospital
Multiple Sclerosis, Vestibular Disease
Conventional Vestibular Training Versus Immersive Virtual Reality- Based Vestibular in Multiple Sclerosis
The effectiveness of convectional vestibular training for balance and dizziness rehabilitation in people with multiple sclerosis has been recently demonstrated in a meta-analysis by this research team (doi: 10.3390/jcm9020590).
- Conditions
- Multiple Sclerosis, Vestibular Disease, Dizziness, Balance Disorders
- Trial name
- NCT04497025
- Testing
- Immersive Virtual-based vestibular rehabilitation, Conventional vestibular rehabilitation protocol
- Where
- Spain
- Sponsor
- Maria Jesus Casuso-Holgado
Multiple Sclerosis
Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects
Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions.
- Trial name
- NCT03424733
- Testing
- Plegridy, Prednisone, Tylenol Pill
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Holy Name Medical Center, Inc.
Multiple Sclerosis
Vitamin D3 and the Stress-axis in MS
Patients with multiple sclerosis (MS) have an increased risk of developing a major depression. The investigators observed a protective effect of high vitamin D levels on the risk of depression in MS.
- Trial name
- NCT02096133
- Testing
- Cholecalciferol
- Where
- 2 sites in Netherlands
- Volunteers
- 54 people
- Sponsor
- Academic MS Center Limburg
Progressive Multiple Sclerosis
Telerehabilitation in Progressive Multiple Sclerosis
Multiple sclerosis (MS) is a highly disabling chronic, inflammatory, demyelinating disease of the Central Nervous System (CNS). Significant progress has been made during the past three decades in managing the relapsing-remitting…
- Trial name
- NCT06485115
- Testing
- Digital Telerehabilitation (Euleria Home), Conventional therapy
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Universita di Verona
Multiple Sclerosis
A Prospective Biomarker Study in Active SPMS Subjects Treated With Cladribine Tablets
The purpose of this study is to explore the concept that biomarker sensitivity will detect activity in Multiple Sclerosis (MS) subjects and allow appropriate change in treatment to prevent dysfunction.
- Trial name
- NCT04550455
- Testing
- Cladribine Tablets
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Keith Edwards, M.D.
Multiple Sclerosis
Effect of Artificial Intelligence Based Cognitive Training on Sleep Disorders and Quality of Life in Patients With Multiple Sclerosis
this study will be conducted to investigate the effect of artificial intelligence (AI) based cognitive training on sleep disorders and quality of life in patients with multiple sclerosis.
- Trial name
- AI (NCT07762326)
- Testing
- cognitive Therapy by artificial intillegence, designed physical-therapy program
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Multiple Sclerosis
A Study to Evaluate the Impact of Using Warm Compress Prior to Daily Injections of Copaxone®
This study is designed to compare skin reactions with or without the use of warm compress prior to performing a Copaxone® injection.
- Trial name
- NCT00239993
- Testing
- glatiramer acetate, Warm compress prior to injection of glatiramer acetate
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Teva Neuroscience, Inc.
Multiple Sclerosis (MS)
Safety and Effectiveness of Nabiximols Oromucosal Spray as Add-on Therapy in Participants With Spasticity Due to Multiple Sclerosis
This trial is being conducted to demonstrate the efficacy of nabiximols, compared with placebo, when added to standard of care, in the treatment of muscle spasms associated with multiple sclerosis (MS).
- Trial name
- RELEASE MSS3 (NCT04203498)
- Testing
- Nabiximols
- Where
- 37 sites in United States, Czechia and 3 more
- Volunteers
- 139 people
- Sponsor
- Jazz Pharmaceuticals
Progressive Multifocal Leukoencephalopathy, AIDS
Treatment of PD-1 Inhibitor in AIDS-associated PML
PD-1 inhibitor （Pembrolizumab, 2mg/kg weight, once per 4 weeks and 3 times of medication usage）treatment on AIDS patients with progressive multifocal leukoencephalopathy.
- Trial name
- TPAP (NCT04091932)
- Testing
- Pembrolizumab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Multiple Sclerosis
Cognitive Stimulation in Patients With Sclerosis Multiple
The primary objective of the study is to determine if the training for 6 months with a specific set of games ( previously selected according to the cognitive domain stimulate : attention, memory , executive functions and…
- Trial name
- JuguEMos (NCT06714487)
- Testing
- cognitive stimulation through games
- Volunteers
- 80 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.