Clinical trials: Demyelinating Disorder
Relapsing Remitting Multiple Sclerosis, Fatigue
Correlation Between Daily Physical Activity and Disability, Fatigue, Cognition and Quality of Life in MS Patients
The main purpose of the study is to assess the fatigue, cognition, quality of life and disability correlation to MS-patients daily physical activity.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Fatigue, Quality of Life, Physical Activity
- Trial name
- PAMS (NCT04115930)
- Testing
- Physical Activity measurement:
- Where
- 4 sites in Finland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Multiple Sclerosis
Prolonged-release Fampridine as Adjunct Therapy to Active Motor Training in MS Patients
Phase 4, single center, double-blind, placebo-controlled study. Fifty (50) patients with MacDonald criteria (2005) multiple sclerosis will undergo active motor training as per the NeuroGym protocol, consisting of 3 sessions of 1…
- Trial name
- NCT02146534
- Testing
- extended release fampridine
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Clinique Neuro-Outaouais
Spasticity, Multiple Sclerosis
One Year Extension Study To Protocol C2/5/TZ:MS-05
Open label, one year extension study to evaluate the clinical efficacy and safety of 12 mg sublingual tizanidine administered once nightly in MS patients who successfully completed Phase I/II protocol C2/5/TZ:MS-05 at the Tel…
- Trial name
- NCT00464958
- Testing
- sublingual tizanidine 12 mg
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Teva GTC
Multiple Sclerosis
Study Of White Blood Cells In The Cerebrospinal Fluid And Blood Of Patients With Relapsing Forms Of Multiple Sclerosis
This is a study to count the number of white blood cells in the cerebrospinal fluid and blood at the beginning and end of treatment with firategrast and at 4 and 12 weeks after stopping firategrast.
- Trial name
- NCT00469378
- Testing
- firategrast
- Where
- 10 sites in Belgium, Czechia and 3 more
- Volunteers
- 46 people
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
Stem Cells in Rapidly Evolving Active Multiple Sclerosis
This is a randomised, double-blind crossover study to study the effect of intravenous treatment with autologous (derived from the individuals themselves) mesenchymal stem cells (MSCs) in patients with multiple sclerosis (MS).
- Trial name
- STREAMS (NCT01606215)
- Testing
- Mesenchymal stem cells
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Imperial College London
Multiple Sclerosis, Cognition
Lipoic Acid and Omega-3 Fatty Acids for Cognitive Impairment in Multiple Sclerosis
The primary aim is to collect data to determine the correct effect size on the primary outcome to aid in the design of a larger study: The primary outcome is to determine if lipoic acid and omega-3 fatty acids can improve…
- Trial name
- NCT02133664
- Testing
- lipoic acid and omega-3 fatty acids
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Thalamic Nuclei Volumes in Multiple Sclerosis
The thalamus is composed of several nuclei interlocked in a complex anatomy. In multiple sclerosis (MS), the thalamus can be altered due to disconnection by white matter lesions and due to direct damages that could be partly…
- Trial name
- THALNUC-MS (NCT05002764)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Bordeaux
Secondary Progressive Multiple Sclerosis
Acceptance Based Telephone Support When Transitioning to SPMS
What is the purpose of the study? People with Multiple Sclerosis often say that they feel less support is available after they are diagnosed with Secondary Progressive Multiple Sclerosis, compared to before they received this…
- Trial name
- AT-SPMS (NCT04239664)
- Testing
- Acceptance Based Telephone Support (ABS+UC)
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Nottingham
Multiple Sclerosis (MS), Cerebral Small Vessel Diseases
MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis
This study investigates whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can improve the differentiation of white matter lesions in people aged 50-70 years with multiple sclerosis (MS).
- Trial name
- NCT07444047
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Multiple Sclerosis, Fatigue
The Effect of the Nurses Support Program on Fatigue in MS Patient
The research will be carried out as a randomized controlled experimental study to examine the effect of a nursing support program supported by a Web-based education program on the management of fatigue symptoms of patients who…
- Conditions
- Multiple Sclerosis, Fatigue, Sleep Hygiene, Quality of Life
- Trial name
- NCT06166043
- Testing
- NURSE FOLLOW-UP PROGRAM SUPPORTED WITH WEB-BASED EDUCATION
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis
Mesenchymal Stem Cells for Multiple Sclerosis
The aim of the study is to evaluate the safety and efficacy of autologous mesenchymal stromal cells as treatment for Multiple Sclerosis.
- Trial name
- NCT01730547
- Testing
- Autologous mesenchymal stem cells
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis
Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis
The primary objective is to determine whether prolonged-release fampridine (10 mg twice daily) has a clinically meaningful effect on participant-reported walking ability over a 24-week study period.
- Trial name
- ENHANCE (NCT02219932)
- Testing
- fampridine
- Where
- 87 sites in United States, Bulgaria and 9 more
- Volunteers
- 646 people
- Sponsor
- Biogen
Multiple Sclerosis
Functional Electrical Stimulation Cycling for Managing Mobility Disability in People with Multiple Sclerosis
Mobility impairment is one of the most common, poorly managed, and life altering consequences of MS. Current therapies for managing MS do not prevent the long-term accumulation of mobility impairment, highlighting the need for…
- Trial name
- NCT03949387
- Testing
- FES Cycling Exercise, Passive Leg Cycling
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Demyelinating Diseases of the Central Nervous System, Child
Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating Diseases
This study aims to evaluate balance ability, core stability, functional capacity, lower extremity muscle strength, and fatigue levels in children diagnosed with central nervous system demyelinating diseases, in order to…
- Conditions
- Demyelinating Diseases of the Central Nervous System, Child, Core Stability, Balance
- Trial name
- PEDI-CORE (NCT07654738)
- Testing
- No ADT
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Multiple Sclerosis
Resilience in Young Adults Newly Diagnosed With Multiple Sclerosis
This study aims to fill the gap of knowledge on the biopsychosocial (BPS) characteristics and resilience of young adults newly diagnosed with Multiple Sclerosis, to evaluate the relationship among these variables, and to develop…
- Trial name
- BPS-ARMS (NCT03825055)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Universita di Verona
Multiple Sclerosis, Rehabilitation
Functional Disorders of the Musculoskeletal System in People With Multiple Sclerosis
The randomized controlled trial is aimed to study the efficacy of treatment approaches based on developmental kinesiology models and its impact on balance, gait and mobility in people with mild to severe multiple sclerosis…
- Conditions
- Multiple Sclerosis, Rehabilitation, Musculoskeletal Complication
- Trial name
- NCT04973501
- Testing
- Manual physiotherapeutic correction (MFK) Method, Dynamic Neuromuscular Stabilization (DNS) Method
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Optic Neuritis, Neuromyelitis Optica
Optic Neuritis Differential Diagnosis Study
Background: Optic neuritis is a frequent cause of vision loss encountered by ophthalmologists in the Caribbean. The diagnosis is made on clinical grounds.
- Conditions
- Optic Neuritis, Neuromyelitis Optica, Multiple Sclerosis
- Trial name
- ONDDS (NCT03370965)
- Testing
- Neuro-ophtalmology examination
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital Center of Martinique
I Cell Disease, Fucosidosis
Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
OBJECTIVES: I. Evaluate bronchoalveolar lavage fluid and serum obtained from pediatric patients with storage disorders prior to allogeneic hematopoietic stem cell transplantation (HSCT) for the presence of proinflammatory…
- Conditions
- I Cell Disease, Fucosidosis, Globoid Cell Leukodystrophy, Adrenoleukodystrophy
- Trial name
- NCT00005900
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fairview University Medical Center
Multiple Sclerosis, Chronic Progressive, Nervous System Diseases
Intrathecal Rituximab in Progressive Multiple Sclerosis
The goal of investigators is to study the kinetics of action of a single dose of intrathecally-infused rituximab upon cerebro-spinal fluid (CSF) biological targets in progressive MS patients.
- Trial name
- EFFRITE (NCT02545959)
- Testing
- Rituximab IT, methylprednisolone IV, Rituximab IV
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier de PAU
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