Clinical trials: Demyelinating Disorder
Multiple Sclerosis
Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis
Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We…
- Trial name
- EDSS (NCT07123337)
- Where
- Libya
- Volunteers
- 369 people
- Sponsor
- University of Zintan
PARKINSON DISEASE (Disorder), Multiple Sclerosis (MS) - Relapsing-remitting
Myrosinase Bioactivated Gglucoraphanin for the Treatment of Neurodegenerative Diseases (GRA-MYR-ND)
Glucosinolates (GLs) are phytocompounds mainly found in the Cruciferae (Brassicacea) and Moringa oleifera plants. The hydrolysis of GLs by myrosinase led to the production of isothiocyanate (ITCs).
- Conditions
- PARKINSON DISEASE (Disorder), Multiple Sclerosis (MS) - Relapsing-remitting, Pediatric Patients Affected by Neuromuscolar and Degenerative Diseases
- Trial name
- GRA-MYR-ND (NCT07360977)
- Testing
- bioactivated GRA for adult patients, bioactivated GRA for pediatric patients
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Peripheral Neuropathy, Diabetes Mellitus
IVIg for Demyelination in Diabetes Mellitus
The purpose of this study is to determine whether intravenous immunoglobulin (IVIg) is an effective intervention for patients with diabetes, peripheral neuropathy, and demyelination on nerve conduction studies.
- Conditions
- Peripheral Neuropathy, Diabetes Mellitus, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- IDIDM (NCT02372149)
- Testing
- 10% intravenous immunoglobulin (IVIg), 0.9% sodium chloride
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Toronto
Multiple Sclerosis
Multiple Sclerosis and Heavy Progressive Resistance Training
The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training.
- Trial name
- NCT00381576
- Testing
- Resistance training
- Where
- 2 sites in Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Multiple Sclerosis
A Multicenter, Open-label Randomized Crossover Trial to Assess Subject Preference for Kemstro™ Compared to Conventional Baclofen Tablets in Subjects With Stable Multiple Sclerosis
This was a multicenter, open-label, randomized, crossover trial in subjects with MS who were already taking a stable dose of baclofen (up to 80 mg/day) for spasticity.
- Trial name
- NCT00139789
- Testing
- Kemstro
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UCB Pharma
Multiple Sclerosis, Multiple Sclerosis Lesion
Artificial Intelligence in Predicting Progression in Multiple Sclerosis Study
The study proposal focuses on multiple sclerosis (MS), a chronic incurable disease of the central nervous system (CNS). The MS disease is characterised by recurrent transient disability progression, quantified by increase in the…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis Lesion, Multiple Sclerosis Brain Lesion
- Trial name
- AI ProMiS (NCT05426980)
- Where
- 4 sites in Slovenia
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Fibromyalgia, Chronic Fatigue Syndrome
Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called [Zr-89]oxine to track the location of white blood cells (also called leukocytes) in the…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
- Trial name
- NCT03807973
- Testing
- [Zr-89]Oxine-labeled leukocytes PET/MRI
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
Study of Empathy in MS
Multiple sclerosis is a chronic inflammatory disease of the central nervous system whose exact etiology remains unclear, underpinned by multiple pathophysiological mechanisms, and is a cause of significant motor and cognitive…
- Trial name
- SEmPathy (NCT05332951)
- Testing
- Interpersonal Reactivity Index
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
Motor Evoked Potentials With Modified Facilitation Technique
Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in…
- Trial name
- EP-F (NCT03646929)
- Testing
- MEP using standard facilitation technique, MEP using modified facilitation technique
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Stroke, Multiple Sclerosis
Exergames Balance Program in Neurorehabilitation
Exergames are games that require physical movements and are used with a therapeutic purpose, e.g. to improve strength, balance or flexibility.
- Conditions
- Stroke, Multiple Sclerosis, Balance Disorders
- Trial name
- NCT03993275
- Testing
- MindMotion GO
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- Klinik Valens
Multiple Sclerosis, Balance
Vestibular Rehabilitation for Persons With Multiple Sclerosis: Who Benefits the Most? (MSVR3trial)
Impaired standing balance, fatigue and abnormal eye movements are common problems in persons with MS. These complaints are related to advanced disability and decreased quality of life for persons with MS.
- Conditions
- Multiple Sclerosis, Balance, Fatigue, Eye Movement
- Trial name
- NCT01698086
- Testing
- Vestibular rehabilitation: balance and eye movement exercises
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis (MS)
Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences
This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the…
- Trial name
- NCT04819737
- Testing
- SC MRI, patient questionnaire
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Learning Strategies for Improving Dual Task Performance in Multiple Sclerosis
This study is a randomized controlled study in which we aim to include 60 persons with Multiple Sclerosis and 30 healthy controls.
- Trial name
- StraDiMS (NCT04538872)
- Testing
- StraDiMS implicit, StraDiMs explicit
- Where
- 2 sites in Belgium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis, Neurofilament Light Chain
To Study the Pathophysiological Features of Multiple Sclerosis
Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system1, whose demyelination is the pathological hallmark.
- Conditions
- Multiple Sclerosis, Neurofilament Light Chain, Glial Fibrillary Acidic Protein
- Trial name
- NCT04242056
- Testing
- 18F-PM-PBB3
- Volunteers
- 38 people
- Sponsor
- Chang Gung Memorial Hospital
Multiple Sclerosis, Sarcopenia
Investigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters
This cross-sectional observational study aims to determine the prevalence of sarcopenia and dynapenia across disability stages in patients with multiple sclerosis (MS) and investigate their associations with clinical and…
- Conditions
- Multiple Sclerosis, Sarcopenia, Dynapenia
- Trial name
- MS-Sarcopenia (NCT07842731)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Neuromyelitis Optica Spectrum Disorders
A Clinical Research Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorders
To assess the efficacy and safety of Inebilizumab in Chinese adult patients with neuromyelitis optica spectrum disorders.
- Trial name
- NCT06212245
- Testing
- Inebilizumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Hansoh BioMedical R&D Company
Multiple Sclerosis
Lokomat Training Effects on MS Gait Abnormalities
Multiple sclerosis is a degenerative disease that affects more than 400,000 people in the US alone. MS is in fact the most common disabling neurological disorder in young adults.
- Trial name
- NCT00766272
- Testing
- Lokomat
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- US Department of Veterans Affairs
Sclerosis, Multiple
Effects of Blood Flow Restriction Training on Middle-aged People With Multiple Sclerosis.
To analyze the effects of a resistance training program based on the blood flow restriction modality on muscle strengthening and functionality in people over 45 years of age with multiple sclerosis (MS).
- Trial name
- NCT06061939
- Testing
- Blood Flow Restriction training with Oclussion Cuff.
- Where
- Spain
- Volunteers
- 94 people
- Sponsor
- University of Jaén
GBS Positive, Women in Labor Given Vancomycin for Prophylaxis
Intrapartum Vancomycin for Group B Streptococcus (GBS) Prophylaxis
While it is clear that intrapartum antibiotics reduce neonatal GBS infection rates, the mechanism by which these drugs prevent neonatal GBS is not well established.
- Trial name
- NCT02143154
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Multiple Sclerosis (MS), Inflammatory Disease
The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervous System.
While significant progress has been made on medical imagery in recent years in the individualization of different lesions in the nervous system for demyelination, axonal loss, atrophy, little progress has been made in the…
- Trial name
- USPIO-CIS (NCT01567553)
- Testing
- USPIO MRI - Gadolinium MRI
- Where
- 5 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
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