Clinical trials: Demyelinating Disorder
Multiple Sclerosis
A Study of Lu AG06466 for the Treatment of Spasticity in Participants With Multiple Sclerosis
The main purpose of this study is to investigate Lu AG06466 as a treatment for spasticity in participants with multiple sclerosis (MS).
- Trial name
- NCT04990219
- Testing
- Lu AG06466
- Where
- 7 sites in United States, Germany
- Volunteers
- 37 people
- Sponsor
- H. Lundbeck A/S
Relapsing Remitting Multiple Sclerosis
Teriflunomide Observational Effectiveness Study
The main goal of this investigator-initiated study is to evaluate the effectiveness and efficacy of Teriflunomide in a population of Relapsing Remitting Multiple Sclerosis (RRMS) patients treated in regular practice, over a…
- Trial name
- NCT02490982
- Testing
- Teriflunomide
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Multiple Sclerosis
The Effect of Hybrid Telerehabilitation-Based Structured Exercise Programs in Patients With Multiple Sclerosis
The aim of our study is to compare the effects of hybrid telerehabilitation (TR)-based exercise program applied in patients with MS, only TR-based exercise program and only clinical-based exercise program on walking speed…
- Trial name
- NCT06293079
- Testing
- Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Biruni University
Multiple Sclerosis (MS) - Relapsing-remitting
Monthly Monitoring of Plasma NfL in Treated Relapsing-remitting Multiple Sclerosis to Detect Persistent Infraclinical Disease Activity
Reference MRI scan is recommended 6 months after treatment onset in patients with multiple sclerosis (MS), and follow-up scans at 12 months later to monitor subclinical activity.
- Trial name
- MoMo-NfL (NCT07292480)
- Testing
- Monthly pNfL monitoring
- Where
- 6 sites in France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis, Clinically Isolated Syndrome
Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis
This project aims to analyze ocular motility problems, visual processing speed and microperimetry, and their relationship with consolidated retinal structural biomarkers (optical coherence tomography, OCT) in patients with…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis
- Trial name
- NCT05706220
- Testing
- Eye tracking, Microperimetry, Optical coherence tomography (OCT)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Multiple Sclerosis
How to Develop the Highest Possible Leading-edge Interdisciplinary Care Model for People With MS, That Will be Relevant to All Stakeholders and Declinable to Different Local Contexts With the Ultimate Goal of Ensuring the Highest Level of Quality of Care in MS.
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating and degenerative disease of the central nervous system. It is currently not curable, although several disease-modifying treatments (DMT) reduce the occurrence of…
- Trial name
- MUSICALISE (NCT07289724)
- Testing
- Focus group, individual interview
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autoimmune Diseases, Multiple Sclerosis
Treatment of Multiple Sclerosis With Copaxone and Albuterol
The purpose of this study is to determine the effects of glatiramer acetate (Copaxone) alone compared to Copaxone plus albuterol in patients with Multiple Sclerosis (MS).
- Trial name
- NCT00039988
- Testing
- Glatiramer acetate, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
Low levels of tissue carnosine and mitochondrial dysfunction appears to accompany multiple sclerosis (MS), with oral carnosine might be applicable to tackle impaired bioenergetics and oxidative stress in MS, and perhaps win back…
- Trial name
- CARMUS (NCT03995810)
- Testing
- Carnosine, capsulle, 2 g/day, 8 weeks
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Spinal Cord Injury/Disorder, Stroke
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis.
- Conditions
- Spinal Cord Injury/Disorder, Stroke, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT07768761
- Testing
- Exercise with Electrical Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Louis Stokes VA Medical Center
Progressive Multiple Sclerosis
Intrathecal Therapy With Monoclonal Antibodies in Progressive Multiple Sclerosis
This is a is a small scale open phase two interventional study to assess long-term stabilising effects of on neurological symptoms by regular intrathecal administered monoclonal antibodies in progressive multiple sclerosis.
- Trial name
- ITT-PMS (NCT01719159)
- Testing
- Rituximab
- Where
- 2 sites in Sweden
- Volunteers
- 23 people
- Sponsor
- Anders Svenningsson
Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), Trauma
Electric Stimulation of the Eye to Improve Vision After Trauma
Transcorneal Electrical Stimulation (TES) using the "OkuStim®" device delivers electrical impulses to damaged and/or diseased photoreceptor cells.
- Conditions
- Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), Trauma, Multiple Sclerosis (MS)
- Trial name
- TES (NCT02019927)
- Testing
- Transcorneal Electrical Stimulation
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Wills Eye
Alcohol-induced Brain Injury
Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury
Alcohol is one of most common harmful substance, and alcohol intake brings great burden on health worldwide. Excess alcohol intake may lead to alcohol-related brain injuries and cognitive impairment.
- Trial name
- NCT03968042
- Testing
- Nerve Growth Factor, Edaravone, Combination of vitamin B1, B6, C, E and mecobalamine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Neuromyelitis Optica Spectrum Disorders
An Open Label Study of the Effects of SHR1459 in NMOSDs Patients
This is an open-label study, to evaluate the efficacy and safety of SHR1459 in participants with NMOSDs.
- Trial name
- NCT04670770
- Testing
- Drug - SHR1459
- Where
- 8 sites in China
- Volunteers
- 10 people
- Sponsor
- Reistone Biopharma Company Limited
Multiple Sclerosis
Dual-Task Performance in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. It is reported that 85% of patients with multiple sclerosis have gait disturbance, 88% balance, and 35-90% fatigue (1, 2, 3).
- Trial name
- NCT03508284
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis, Endocrine System Diseases
Trabecular Bone Score in Multiple Sclerosis
Assess bone quality in MS patients through TBS and evaluate the potential effects exerted by different drugs used in MS treatment, which may affect BMD and TBS in MS patients
- Conditions
- Multiple Sclerosis, Endocrine System Diseases, Neurologic Disorder
- Trial name
- NCT05811689
- Testing
- sm tbs group
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Guillain-Barre Syndrome
Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome
OBJECTIVES: I. Compare the efficacy of plasmapheresis and human immunoglobulin infusion in minimizing morbidity and augmenting the pace of recovery in children with Guillain-Barre syndrome. II.
- Trial name
- NCT00004833
- Testing
- Immune globulin
- Volunteers
- 170 people
- Sponsor
- Emory University
Multiple Sclerosis, Neuromyelitis Optica
Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct
The purpose of this study is to determine the ability of STRATUS OCT and high resolution OCT to detect and to quantify the neural loss in multiple sclerosis and neuromyelitis optica and its subtypes.
- Trial name
- NCT01024985
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
A Proof of Concept Study With Rituximab in Patients With CIDP Not Responding to Conventional Immune Therapy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic and often disabling neuropathy that often responds to immune therapies.
- Trial name
- NCT05877040
- Testing
- Rituximab
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Clinico Humanitas
Multiple Sclerosis
High Intensity Interval Training for People With Mild Multiple Sclerosis: A Feasibility Study
Exercise has been shown to improve quality of life in people with multiple sclerosis but most exercise programmes are carried out at low to moderate intensities.
- Trial name
- HIIT-MS (NCT02702804)
- Testing
- High Intensity Interval Training
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Multiple Sclerosis
Physical Activity Intervention for Improving Vascular Comorbidity Risk in Multiple Sclerosis
Vascular comorbidities, such as high cholesterol, obesity, high blood pressure, and diabetes, are common among people with multiple sclerosis (MS), and can negatively impact disease diagnosis, treatment, and progression.
- Trial name
- NCT03944538
- Testing
- Lifestyle Physical Activity, General Wellness
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Ottawa
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