Clinical trials: Demyelinating Disorders
Multiple Sclerosis
The Reliability and Validity of the L-test in Patients With Multiple Sclerosis
Walking safely inside or outside is an important function in patients with Multiple Sclerosis (PwMS) that affects their daily life activity and participation.
- Trial name
- NCT05641714
- Testing
- L test, Timed Up and Go test, 10 meter walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gazi University
Spinal Cord Injuries, Multiple Sclerosis
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis
The UAB Institute for Arts In Medicine (AIM) is currently implementing an expressive emotional writing pilot project for adults with paralysis caused by neurological conditions such as traumatic head or spinal cord injury.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Transverse Myelitis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT04721717
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
The Synergistic Effects of AIH and FES in Persons With MS
The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06413602
- Testing
- Acute Intermittent Hypoxia, Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Clinically Isolated Syndrome, Multiple Sclerosis
Dose-related Effects of Vitamin D3 on Immune Responses in Patients With Clinically Isolated Syndrome
The primary purpose of this study is to assess the immune response to vitamin D supplementation at two doses (5,000 IU and 10,000 IU daily) in both healthy controls and patients with clinically isolated syndrome compared to…
- Trial name
- CISAVID (NCT01728922)
- Testing
- 5000IU vitamin D, 10000IU vitamin D
- Where
- Ireland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Multiple Sclerosis
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and…
- Trial name
- NCT04699747
- Testing
- F-18 3F4AP
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Restless Legs Syndrome, Multiple Sclerosis
Hypnosis and Direct Autonomic Experience Influence on Chronic Symptoms
Study will look at a limited number of participants with various chronic symptoms. Investigating a new and novel form of hypnosis application called "Direct Autonomic Experience (DAX)" which is using combination of visualization…
- Conditions
- Restless Legs Syndrome, Multiple Sclerosis, Trauma, Psychological, Chronic Disease
- Trial name
- HDAX1 (NCT04303143)
- Testing
- Self-Hypnosis, Direct Autonomic Experience Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inner Group Inc.
Alzheimer's Disease, Parkinson's Disease
Rajavtihi Neuronal Adult Stem Cells Project
To study the success of Oligodendrocyte progenitor cell culture project in Rajavithi Hospital to identify an unlimited clone human neuronal progenitor stem cells from the human brain in the Biomolecular Research Center.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis
- Trial name
- RNASc (NCT00927108)
- Testing
- Progenitor Stem Cell Culture
- Where
- Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Multiple Sclerosis
Plantar Pressure Distribution in Patient With Multiple Sclerosis
Fifty patients who were referred to receive physiotherapy and 20 healthy volunteers will be participants of the study.Participants with multiple sclerosis will evaluate with the following assessment tools: Modified Ashworth scale…
- Trial name
- NCT02947906
- Testing
- No intervention
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Multiple Sclerosis
Sunlight-mediated Inter-organ Leukocyte Exchange
Ultraviolet B (UVB) irradiation induces regulatory immune cell types that may transmigrate from the skin to the blood and to the central nervous system and exert regulatory effects.
- Trial name
- SMILE (NCT05627609)
- Testing
- 311 nm narrowband UVB irradiation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis
Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis, Cognitive Deficits, Motor Deficits
- Trial name
- MScog-tDCS (NCT02266121)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
X-linked Adrenoleukodystrophy
Registry of X-linked Adrenoleukodystrophy
This study is a observational study conducted through recruiting X-linked adrenoleukodystrophy (X-ALD) patients, to build a comprehensive evaluation and long-term follow-up platform for X-ALD patients, and to provide a…
- Trial name
- NCT05939232
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Multiple Sclerosis
Learning Strategies for Improving Dual Task Performance in Multiple Sclerosis
This study is a randomized controlled study in which we aim to include 60 persons with Multiple Sclerosis and 30 healthy controls.
- Trial name
- StraDiMS (NCT04538872)
- Testing
- StraDiMS implicit, StraDiMs explicit
- Where
- 2 sites in Belgium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Healthy, Prodromal Alzheimer's Disease
Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
Neurodegenerative diseases are a major health concern due to their growing societal implications and economic costs. The identification of early markers of pathogenic mechanisms is one of the current main challenges.
- Conditions
- Healthy, Prodromal Alzheimer's Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- GutBrain (NCT05934188)
- Testing
- Magnetic Resonance Imaging, Neuropsychological protocol, Eating habits
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Fatigue, Functionality
The Effect of the Level of Hand Fatigability on Multiple Sclerosis on General Fatigue and Functionality
The objective of this study is to investigate the effect of the level of hand fatigability on general fatigue and functionality by comparing Relapsing-Remitting Multiple Sclerosis individuals with age and sex-matched healthy…
- Conditions
- Fatigue, Functionality, Multiple Sclerosis, Dexterity
- Trial name
- NCT05880745
- Testing
- Nine-Hole Peg Test (NHPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Multiple Sclerosis
Improving Hand Movement and Coordination in People With Multiple Sclerosis Using Transcranial Magnetic Stimulation (TMS) and Muscle Electrostimulation (FES) To Support Manual Dexterity and Daily Function
The goal of this interventional study is to test whether combining transcranial magnetic stimulation (TMS) with functional electrical stimulation (FES) can improve hand and upper limb function in adults with Multiple Sclerosis…
- Trial name
- MANTRAStim (NCT07098273)
- Testing
- TMS and FES- based rehabilitation, FES-based rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
B Cell Differentiation in MS
Interventional study with minimal risks and constraints, prospective, monocentric.
- Trial name
- ABCD-SEP (NCT03744351)
- Testing
- Biological Samples
- Where
- France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Progressive Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis
The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the…
- Trial name
- VASOSEP (NCT02580669)
- Testing
- Neuropsychological assessment, Neurologic consultation, MRIs (with vasoreactivity testing)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Pathologic-MRI Findings in Atypical IIDD
Our objective is to describe the pathologic and MRI findings in a series of patients with presumed demyelinating lesion of the central nervous system.
- Trial name
- IIDD (NCT03121105)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
Expression of PARP-1 in Multiple Sclerosis Patients
This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients. The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021.
- Trial name
- NCT05196425
- Testing
- Blood sampling
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University