Clinical trials: Demyelinating Disorders
Insomnia Chronic, Multiple Sclerosis
Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis
Purpose To determine whether Mindfulness-Based Treatment for Insomnia (MBTI) is more effective in the treatment of chronic insomnia disorder (CID) in patients with multiple sclerosis (MS) when compared with standard sleep hygiene…
- Trial name
- NCT03949296
- Testing
- Mindfulness Intervention, Sleep Hygiene
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Griffin Hospital
Multiple Sclerosis
Virtual Reality for Upper Limb Rehabilitation in Multiple Sclerosis
This study is aimed to test the efficacy and feasibility of an immersive virtual reality (VR) rehabilitation programs to improve upper-limb motor functions in 24 patients with multiple sclerosis (pwMS), characterized by moderate…
- Trial name
- NCT04027491
- Testing
- Virtual Reality
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Cagliari
Multiple Sclerosis
[18F]F-DED PET Imaging of Reactive Astrocytes in Multiple Sclerosis
Despite significant advancements in multiple sclerosis (MS) treatment over the past decade, a specific imaging biomarker for predicting disease progression remains lacking.
- Trial name
- F-DED PET MS (NCT07805473)
- Testing
- [18F]fluorodeprenyl-D2
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Parc de Salut Mar
Optic Neuritis
Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic Neuritis
This study evaluates the length of optic nerve lesion on 3D-DIR sequence as an imaging biomarker predictive of retinal axonal loss and visual disability, 12 months after the occurence of a first clinical episode of optic neuritis.
- Trial name
- IRMANO (NCT03651362)
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis, Physical Activity
Pilates Training in Multiple Sclerosis
To date, despite recent advances in MS care including rehabilitation interventions, many PwMS are unable to access these developments due to limited mobility, fatigue and related issues, and costs associated with travel.
- Trial name
- MS-FIT (NCT04011579)
- Testing
- MSFIT
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Progressive Multiple Sclerosis, Depression
Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients
This trial explores the use of immersive virtual reality (VR) nature-based experiences as a supplementary treatment for depression in individuals with progressive multiple sclerosis (MS).
- Trial name
- NCT07392879
- Testing
- Virtual Reality, Standard care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Multiple Sclerosis
MS and Health Cohort
This study aims to identify clinical, biological, imaging, and environmental factors that predict the progression and severity of Multiple Sclerosis (MS).
- Trial name
- MS-Health (NCT07645703)
- Volunteers
- 2,000 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Secondary Progressive Multiple Sclerosis With Inflammatory Disease Activity
Swiss Study of the Impact of Mayzent on SPMS Patients in a Long-term Non-interventional Study
This study is a national, prospective, multicenter, non-interventional (observational) study with the aim to describe the impact of Siponimod treatment in a real-world SPMS population in Switzerland who are treated with Siponimod…
- Trial name
- SWISSMASIA (NCT04895202)
- Testing
- Siponimod
- Where
- 6 sites in Switzerland
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, MS (Multiple Sclerosis)
At Home Use of Stimulation Suits for Managing MS Symptoms
This study is being carried out at Multiple Sclerosis (MS) centers to evaluate whether a full-body stimulation suit at home can help people with Multiple Sclerosis (pwMS) reduce symptoms like spasticity (muscle stiffness) and…
- Conditions
- Multiple Sclerosis, MS (Multiple Sclerosis), Spasticity With Multiple Sclerosis, Ataxia - Other
- Trial name
- HANDS-MS (NCT07202195)
- Testing
- electro-stimulation suit, Usual Care
- Where
- 2 sites in Belgium, Denmark
- Volunteers
- 70 people
- Sponsor
- Daphne Kos
Multiple Sclerosis, Dysphagia
Effects of CTAR and PNF Exercises on Swallowing in Multiple Sclerosis
This study compares two exercise programs for people with multiple sclerosis (MS) who have trouble swallowing. One group did chin exercises against resistance (CTAR), and the other group did neck exercises based on a technique…
- Conditions
- Multiple Sclerosis, Dysphagia, Deglutition Disorders
- Trial name
- CTAR-PNF-MS (NCT07726667)
- Testing
- CTAR exercise, PNF exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Sanko University
Spinal Cord Injuries, Multiple Sclerosis
Polish Translation and Validation of NBSS, Qualiveen and SF-Qualiveen
The aim of this study is to translate, culturally adapt, and validate Polish versions of the NBSS, Qualiveen and SF-Qualiveen questionnaires.
- Trial name
- NCT04185792
- Testing
- NBSS, Qualiveen and SF-Qualiveen
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Multiple Sclerosis, Nurse's Role
The Effect of Nurse Practitioner (NP-led) Care Upon Mood in People With Multiple Sclerosis
MS is the leading cause of non-traumatic disability in young adults. Canada and Alberta, have the highest prevalence of people with multiple sclerosis (PwMS) in the world.
- Trial name
- NCT04388592
- Testing
- Nurse Practitioner (NP) Led Care Arm
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- University of Alberta
Guillain-Barre Syndrome
Safety Study of GBS Following Menactra Meningococcal Vaccination
We are conducting a large, record-based study to assess the risk of Guillain-Barré Syndrome (GBS), a serious demyelinating disease, following immunization with the tetravalent meningococcal conjugate vaccine (Menactra) that is…
- Trial name
- NCT00575653
- Where
- 6 sites in United States
- Volunteers
- 6,000,000 people
- Sponsor
- Harvard Pilgrim Health Care
Multiple Sclerosis
Determination of Compliance to Mediterranean Diet, Impacts on Walking and Quality of Life in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease characterized by inflammation, demyelination and axon damage. Affecting approximately 2.5 million individuals around the world and seen mostly in young adults, MS can cause…
- Trial name
- NCT05777629
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- University of Gaziantep
Multiple Sclerosis
Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis
This study is to find out if there is any benefit to adding Simvastatin to Interferon-beta-1a in patients with Multiple Sclerosis.
- Trial name
- SIMCOMBIN (NCT00492765)
- Testing
- Interferon-beta-1a, Simvastatin
- Where
- Denmark
- Volunteers
- 380 people
- Sponsor
- Biogen
Multiple Sclerosis, Depression
Depression and Facial Identity Recognition Abilities in Patients With Multiple Sclerosis
Cognitive and emotional disorders are often encountered in multiple sclerosis (MS) cases: depressive and bipolar disorders are twice as frequent as in general population.
- Trial name
- SepDep (NCT02468765)
- Testing
- Neuropsychological and emotional evaluation with monitoring
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Multiple Sclerosis
Telerehabilitation-based Upper Extremity Training in People With Multiple Sclerosis
In this studly, the effects of an 8-week telerehabilitation-based upper extremity training in persons with multiple sclerosis will be investigated.
- Trial name
- NCT05073731
- Testing
- Telerehabilitation-based Upper Extremity Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dokuz Eylul University
Multiple Sclerosis
Testosterone Treatment for Multiple Sclerosis
Since men are less likely to develop multiple sclerosis, the hypothesis was that testosterone might be protective in MS. Men with MS for followed untreated for 6 months, followed by a 12 month treatment period with Androgel.
- Trial name
- NCT00405353
- Testing
- Androgel 10 grams of gel containing 100 mg of testosterone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis
Fatigue and Inspiratory Muscles Training in Patients With Multiple Sclerosis
The purpose of this study is to assess the effect of a training of the inspiratory muscles against resistance at home during 10 weeks in multiple sclerosis patients with a severe disability.
- Trial name
- AIRSEP (NCT02726672)
- Testing
- respiratory rehabilitation using Powerbreathe
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Lille Catholic University
Relapsing-Remitting Multiple Sclerosis
Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS
MS has been associated with fatigue, attention problems, and a number of cognitive difficulties. There is no treatment approved yet to treat these problems.
- Trial name
- NCT00210301
- Testing
- Provigil (modafinil)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute for Clinical Research