Clinical trials: Dental Caries
Deep Carious Lesions, Partial Caries Removal
This Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over the Pulp, Utilizing Three-dimensional Imaging Following the Application of a Bioactive Restorative System Versus a Conventional Restorative System After Selective Caries Removal to Soft Dentin Over 2
This clinical trial aims to evaluate dentin bridge formation over the pulp following selective caries removal in permanent teeth with deep carious lesions (ICDAS scores 5-6).
- Conditions
- Deep Carious Lesions, Partial Caries Removal, Dentin Bridge
- Trial name
- NCT07171775
- Testing
- Experimental - Bioactive Restorative System, Active Comparator -Conventional Restorative System
- Volunteers
- 66 people
- Sponsor
- Cairo University
Dental Caries, Dental Atraumatic Restorative Treatment
Oral Health and Its Relation to Development and Well-being of Schoolchildren Before and After Restorative Treatments
The present study aims evaluate the oral health conditions of schoolchildren and its relation to growth, development and well-being.
- Conditions
- Dental Caries, Dental Atraumatic Restorative Treatment, Oral Health
- Trial name
- NCT02754466
- Testing
- Subjective vs objective criteria in selective excavation, Glass-ionomer vs Bulk fill composites in the ART approach
- Where
- Brazil
- Volunteers
- 270 people
- Sponsor
- University of Brasilia
Caries, Dental
Clinical Evaluation of Bioactive Resin Sealants vs Conventional Sealants in Permanent Molars
This study will be conducted to evaluate the performance; in terms of retention and caries inhibition; of the newly introduced bioactive resin based pits and fissure sealant versus conventional resin based pits and fissure…
- Trial name
- NCT03779893
- Testing
- BioCoat® by Premier®., 3M™ Clinpro™ Sealant.
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Class II Dental Caries
Clinical Performance of Bulk-Fill Composite Using With Adhesives With or Without Chlorhexidine
This study aims to evaluate the clinical success of chlorhexidine-containing dentin bonding agent in primary molars with a 12-month follow-up.
- Trial name
- NCT06257108
- Testing
- Class II Cavity Restorations
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uşak University
Osteoporosis, Dental Caries
Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured.
- Conditions
- Osteoporosis, Dental Caries, Biomarkers, Matrix Metalloproteinase 8
- Trial name
- NCT07709247
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Early Childhood Caries, Dental Caries
Vertical Dimension Changes After Bioflx vs Stainless Steel Crowns in Primary Molars
this randomized controlled trial will compare Bioflx crowns and stainless-steel crowns in children with pulp-treated primary molars.
- Conditions
- Early Childhood Caries, Dental Caries, Pulp-Treated Primary Molars
- Trial name
- BIOFLX-SSC-RCT (NCT07523776)
- Testing
- Bioflx Crown, Stainless Steel Crown
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University
Caries,Dental, Sensitivity, Tooth
Post-operative Sensitivity in Resin Composites
This triple-blind, randomized clinical trial was conducted at the department of Operative dentistry. A total of 60 participants were recruited and were randomly distributed into two groups A and B.
- Trial name
- NCT06242184
- Testing
- Group A(Nano-fortified Adhesive), Group B(Adhesive without nanoparticles)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Dental Caries
Clinical Performance and Wear Resistance of Highly Translucent Nano Zirconia Reinforced Glass Ionomer Filling Versus Conventional Resin Composite Restorations in Patients With Proximal Carious Teeth. (A One-year Randomized Clinical Trial).
This randomized clinical study aims to evaluate the clinical performance and occlusal wear resistance of nano-zirconia reinforced glass ionomer restorations in comparison to Nano-hybrid resin composite in proximal cavities.
- Trial name
- NCT05403008
- Testing
- Zirconomer improved
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Pulp Exposure, Dental
Comparative Clinical and Radiographic Evaluation of Different Pulpotomy Materials in Primary Molars
This randomized clinical trial compared the clinical and radiographic outcomes of ferric sulfate (FS), mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM), and TheraCal PT used for pulpotomy in primary molars.
- Conditions
- Dental Caries, Pulp Exposure, Dental, Primary Teeth, Primary Molar Pulpotomy
- Trial name
- NCT07769697
- Testing
- Pulpotomy, Mineral Trioxide Aggregate (MTA), Calcium-Enriched Mixture (CEM)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Inonu University
Myopia, Dental Caries
Bedtime Routines and Children's Health
In Taiwan, the prevalence of sleep problems, myopia, and dental caries in school-age children is high. Little is known regarding the implementation of oral and vision health outcomes around bedtime.
- Conditions
- Myopia, Dental Caries, Sleep, Asthenopia
- Trial name
- NCT05201924
- Testing
- Bedtime routine, Control
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Dental Caries on Pit and Fissure Surface
Effectiveness of Fissure Sealants Bonded With Different Universal Adhesives
The purpose of this study is to evaluate and compare the clinical retention of a resin-based fissure sealant placed with prior application of etch-and-rinse and self-etch modes of universal adhesives.
- Trial name
- NCT02897089
- Testing
- Adhesive agent
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries, Quality of Life
Impact of Two Recall Intervals on Dental Caries Incidence, Anxiety and Quality of Life of Preschool Children
Objectives: To assess the effectiveness of two recall intervals on dental caries incidence (primary outcome) in preschool children with low and moderate caries risk.
- Conditions
- Dental Caries, Quality of Life, Anxiety
- Trial name
- NCT02263768
- Testing
- Oral clinical conditions
- Where
- Brazil
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Preschool Children, Dental Caries in Primary Teeth
A Comparison of Teledentistry vs Clinical Examination for Treatment Needs Assesment
Dental caries is one of the most common chronic diseases in children and may require complex dental treatment, especially in preschool-aged children.
- Trial name
- NCT07625982
- Testing
- Tele- dentistry intraoral exam
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
White Spot Lesion
Fluoride Controlled-release System for Initial Lesions of Caries
OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in a controlled-release system (F-CSL, patent pending) in the remineralization of white spot lesions of caries in caries-active…
- Trial name
- NCT05139966
- Testing
- Mouthwash Product
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Substance-Related Disorders, Dental Caries
A Comparative Feasibility Study to Assess the Prevalence and Severity of Dental Caries in Incarcerated People Who Abuse Methamphetamine
The prevalence and severity of dental caries in incarcerated people who abuse drugs are unknown but an inmate reporting to the dental clinic typically presents with myriad findings: oral signs of uncontrolled decay on the buccal…
- Trial name
- NCT01224002
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Post-operative Sensitivity, Dentin Hypersensitivity
Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations
The aim of this study is to compare the effectiveness of Gluma desensitizer in reducing post-operative sensitivity following composite restorations in posterior teeth.
- Conditions
- Post-operative Sensitivity, Dentin Hypersensitivity, Dental Caries, Tooth Sensitivity After Composite Restorations
- Trial name
- NCT07188142
- Testing
- Drug/Agent: Gluma Desensitizer, Drug/Agent: No desensitizer (Control)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Beenish Hassan
Caries Experience
Evaluation of Dental Caries Using Caries Assessment Spectrum and Treatment Need (CAST) Index, International Caries Detection and Assessment System (ICDAS) Index and World Health Organization (WHO) Index
This study goals is to compare the three indices in Egyptian children aged 4 to 6 years in caries detection and time needed for the assessments which will contribute to valuable data for pediatric oral health assessments both…
- Trial name
- CAST/ICDAS/WHO (NCT06858462)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites
IRB4729 Study Hypothesis: Is there a significant difference in the hard and soft tissue response comparing immediate with delayed implant after tooth removal, with immediate provisionalization, in maxillary anterior sites.
- Trial name
- NCT01244997
- Testing
- Dental Implant
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
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