Clinical trials: Dental Caries
Dental Cervical Non-carious Lesion
Glass Hybrid Versus Composite Restorations of Non-carious Cervical Lesions
A glass hybrid restorative system (EQUIA forte) clinically compared to a composite resin based material (Clearfil SE Bond, Filtek Supreme XT) for the treatment of dental non-carious cervical lesions.
- Trial name
- NCT02631161
- Testing
- Equia Forte, Filtek Supreme XT/Clearfil SE Bond
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Evaluations, Diagnostic Self, Antimicrobial
ZnO Nanoparticles Coated Orthodontic Molar Tube
Orthodontic treatment is an elective procedure to improve the patient's dentofacial appearance. The complex design of fixed appliances provides a platform that leads to increased plaque accumulation around orthodontic brackets.
- Conditions
- Evaluations, Diagnostic Self, Antimicrobial, Orthodontic Appliance Complication, Bacterial Overgrowth
- Trial name
- ZnONPs (NCT06089720)
- Testing
- Zinc oxide nanoparticle coated orthodontic molar tubes (experimental), orthodontic molar tubes (control)
- Where
- Iraq
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Insufficient Dental Filling or Primary Caries (Class I or II Cavities in Premolars or Molars)
Clinical Evaluation of a New Flowable and a New Sculptable Universal Bulk-fill Composite for Direct Restorative Treatment
The overall objective of this clinical investigation is to evaluate the clinical safety and performance of the new flowable composite TM Flow and the new sculptable composite TM Fill for restoration of class I and class II…
- Trial name
- NCT06369779
- Testing
- TM Fill in combination with TM Flow
- Where
- Liechtenstein
- Volunteers
- 65 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Dental Caries, Dental Plaque Accumulation
Miswak (Salvadora Persica) Versus a Toothbrush in Plaque Removal
The study investigates the effectiveness of a 45°-cut miswak for plaque removal compared to a toothbrush in children and assesses their preferences for these tools.
- Trial name
- NCT07409610
- Testing
- Miswak, Toothbrush
- Where
- Saudi Arabia
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Class II Dental Caries, Dental Caries
Comparison of the Functional Properties of Two Injectable Materials in Posterior Teeth: Randomized Clinical Trial
Using two different injectable materials in class II cavities to compare functional properties
- Conditions
- Class II Dental Caries, Dental Caries, Injectable Composite
- Trial name
- NCT06894186
- Testing
- Gaenial universal injectable
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Caries, Periodontitis
Salivary IgA and Cytokines Response to Dietary Supplementation of Lactobacillus Reuteri
To evaluate the effect of daily ingestion of the probiotic Lactobacillus reuteri on the levels of secretory IgA and the cytokines Il1-beta, IL-6, IL-8 and IL-10 in saliva of healthy young adults.
- Trial name
- NCT02017886
- Testing
- L. reuteri DSM 17938/ATCC PTA
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dental Caries, Hydroxyapatite
Study of People's Profile Living in France Who Could be Interested in the Use of a Nanohydroxyapatite Toothpaste
Nano-hydroxyapatite is an interesting candidate to be a substitute for fluor in toothpastes or a complement to fluorides in order to prevent caries.
- Trial name
- NCT05234060
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hiv
Impact of CMV Status on HIV Viral Load Decay
Background: Cytomegalovirus (CMV) infection is usually observed among patients with HIV infection. No study to date has investigated the impact of CMV infection on HIV viral load decay during antiretroviral therapy.
- Trial name
- NCT03349359
- Testing
- HIV antiretroviral therapy
- Where
- France
- Volunteers
- 345 people
- Sponsor
- Hospices Civils de Lyon
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Investigation of the F-Composite 2 System in Direct Filling Therapy
The objective of this study is to evaluate the clinical performance of F-Composite 2 system in Class I and Class II cavities in permanent teeth.
- Trial name
- NCT03221660
- Testing
- F-Composite 2 system
- Where
- Liechtenstein
- Volunteers
- 50 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries, Irreversible Pulpitis
Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irreversible Pulpitis
This study evaluates the effectiveness of photobiomodulation (PBM) in conjunction with mineral trioxide aggregate (MTA) pulpotomy for treating irreversible pulpitis in immature first permanent molars.
- Trial name
- NCT06730360
- Testing
- MTA Pulpotomy without photobiomodulation, MTA Pulpotomy with Photobiomodulation (LLLT)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Eczema, Allergy
Probiotics in Prevention of Allergies, Obesity and Caries
During the period of 2000-2003, 179 healthy, term infants with no previous signs of allergic disease were recruited and randomized to daily intake of cereals with or without the addition of Lactobacillus paracasei subspecies…
- Conditions
- Eczema, Allergy, Asthma, Obesity
- Trial name
- ELEFANT (NCT00894816)
- Testing
- Lactobacillus F19
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Umeå University
Class II Dental Caries
Comparative Clinical Evaluation Between a Novel Self Adhesive and Conventional Bulk-fill Composites
This study aimed to evaluate the clinical performance of a novel, tooth-colored, self-adhesive bulk-fill restorative, and a conventional bulk-fill composite, for restoring class II cavities.
- Trial name
- NCT06120868
- Testing
- Surefil one®, Filtek One
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Nourhan M.Aly
Dental Caries
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct Treatment of Deep Carious Lesions in Children
This project aims to evaluate the effect of antimicrobial photodynamic therapy (aPDT) in deep carious lesions. This study was approved by the Research Ethics Committee and was conducted on 53 patients between 3 and 12 years.
- Trial name
- NCT02908789
- Testing
- Antimicrobial photodynamic therapy (aPDT), Without Antimicrobial phothodynamic therapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Dental Caries
Efficacy of Hall Technique in Atypical Lesions on Primary Teeth
Atypical carious cavities could be defined as carious lesions in more than 2 surfaces of the same tooth. Dental practitioners have shown difficulties related to material's maintenance in such type of cavities and therefore…
- Trial name
- SLM2078 (NCT02782390)
- Testing
- Dental Restoration with Stainless Crown, Dental Restoration with Composite Resin
- Where
- Brazil
- Volunteers
- 364 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Dental Caries, Child Discomfort
Child Discomfort and Parental Acceptability of Silver Diamine Fluoride and Alternative Restorative Treatment
The aim of the current study was to compare pain perception of young children treated with SDF and ART, as well as their parents' acceptability of both modalities.
- Trial name
- NCT04654624
- Testing
- SDF, ART
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Nourhan M.Aly
Dental Health, Caries
Efficacy of Proximal Caries Infiltration
The goal of the project is to investigate the clinical efficacy of management of early caries lesions by resin infiltration and to further scrutinize the patient stress experiences.
- Trial name
- NCT01726179
- Testing
- Resin infiltration, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Substance Abuse, Dental Caries
Drug-free Without Toothache. A Study of Free Dental Treatment as a Part of Substance Abuse Treatment
Objectives: The main objective of the study is to investigate 1. How many patients will attend and complete dental care if they are offered it for free during the stay at "The department of substance abuse treatment, University…
- Trial name
- RUST (NCT05606562)
- Testing
- Dental care
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Secondary Caries, Dental Restoration Failure of Marginal Integrity
Comparative Evaluation of Class V Restorations
To evaluate and compare the 2-year clinical performance of Class V restorations using various restorative systems with ion-releasing and non-ion-releasing composites, utilizing fluoride-free and fluoride-releasing universal…
- Trial name
- NCT06164418
- Testing
- Dental restoration
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mansoura University
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