Clinical trials: Dental Erosion
Tooth Erosion
In Vivo Investigation of Initial Stages of Enamel Erosion
This exploratory study is designed to help develop a clinical model to measure the earlier stages of dietary acid medicated enamel loss. The study will use fluoride as positive control to explore the validity of this design.
- Trial name
- NCT02533466
- Testing
- Sodium fluoride + potassium nitrate, Potassium nitrate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Non-carious Cervical Lesions
Evaluation of the Solvent Evaporation Time of Universal Adhesives in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of prolonging solvent evaporation time on the 6- and 12-months clinical performance of two universal adhesive systems used as selective enamel etch (SEE).
- Trial name
- NCT05945173
- Testing
- Evaporation time for 5 seconds, Evaporation time for 25 seconds, alcohol/water-based universal adhesive
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Gastro Esophageal Reflux, Dental Erosion
Domiciliary Management of Dental Erosion in Patients With GERD With Biomimetic Hydroxyapatite
The aim of the present study is to evaluate dental erosion in patients with gastroesophageal reflux disease (GERD). Patients consenting to participate to the study will undergo periodontal evaluation at the baseline.
- Trial name
- NCT05371717
- Testing
- Domiciliary use of Biorepair Total Protection + Biorepair Shock Treatment, Biorepair Total Protection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Dental Erosion
12 Months Clinical Follow-up of Non-Carious Cervical Lesions Restored With New Injectable Composite
Non-carious cervical lesions are defined as loss of pathological material not associated with caries in the enamel-cement junction of the tooth.
- Trial name
- NCT04095520
- Testing
- Laser Etching, Phosphoric acid etching
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Dental Erosion
Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks
40 specimens were prepared from fresh-extracted human molars and further embedded using the acrylic resin. Specimens were randomly divided into 2 groups according to the treatment before in vivo erosion (n=20): CPP-ACP for 3 min…
- Trial name
- NCT03426150
- Testing
- CPP-ACP
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Non-carious Cervical Lesions
Evaluation of the Reduced Dentin Etching Time Using Universal Adhesives in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of reduced dentin etching time on the 6- and 12-months clinical performance of two universal adhesive systems used as etch-and-rinse application mode in non-carious cervical…
- Trial name
- NCT06465849
- Testing
- Dentin Etching time for 5 seconds, Scotchbond Universal Plus; 3M, Gluma Universal Bond; Kulzer
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Dental Erosion
Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
The purpose of this study is to determine whether an experimental fluoridated dentifrice is effective in the treatment of dental caries
- Trial name
- NCT00752089
- Testing
- NaF/ KNO3/isopentane Dentifrice, NaF/KNO3 Dentifrice, NaF Dentifrice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Erosion
Intra Oral Kinetics of Fluoride Containing Dentifrices
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of…
- Trial name
- NCT02548156
- Testing
- Test Dentifrice, Reference Dentifrice, Comparator Dentifrice
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion
Dental Erosion in Patients With Gastro-oesophageal Reflux
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
- Trial name
- NCT02775149
- Testing
- Collection of saliva samples, Visual detection of BEWE-index
- Volunteers
- 30 people
- Sponsor
- University of Göttingen
Dental Erosion
The Effect of Nitrate Supplement on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when teeth lose some of their parts because of acid from the things people eat and/or drink or even from their stomach. It can make their teeth hurt and become sensitive.
- Trial name
- NCT06156618
- Testing
- Nitrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Congenital Heart Defect, Dental Caries in Children
Oral Health Intervention Program for Children With Congenital Heart Defects
Background: Children with congenital heart defects (CHD) are reported to have poorer oral health compared with healthy children.
- Conditions
- Congenital Heart Defect, Dental Caries in Children, Dental Erosion, Dental Plaque
- Trial name
- NCT03311438
- Testing
- Oral health intervention program
- Volunteers
- 75 people
- Sponsor
- University of Bergen
Dentine Hypersensitivity, Tooth Erosion
The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity
Tooth hypersensitivity due to dental erosion is one of the most common problem related to swimming in improper pH chlorinated pools.
- Trial name
- NCT03515902
- Testing
- mouthguard, mouthguard with desensitizing toothpaste
- Where
- Thailand
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Tooth Erosion
Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness
The investigators have now established a technique to measure enamel thickness which has been shown to work well in-vitro. The teeth tested so far, obtained from the Dental School Tissue Bank, have been molars or pre-molars.
- Trial name
- UMET (NCT01622920)
- Testing
- Ultrasound transducer
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Dental Erosion, Gastroesophageal Reflux
Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion
Dental erosions, the chemical dissolution of enamel without bacterial involvement, are considered to be an established complication of gastroesophageal reflux disease (GERD) by the Montreal global consensus statement.
- Trial name
- NCT02087345
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Brain-Gut Research Group
Dental Erosion, Erosive Tooth Wear
Quantitative In Vivo Monitoring of Early Erosion-Associated Enamel Optical Changes Using Swept-Source Optical Coherence Tomography.
This study aims to evaluate the ability of swept-source optical coherence tomography (SS-OCT) to detect early enamel optical changes associated with erosive tooth wear under clinically relevant in vivo conditions.
- Trial name
- NCT07690644
- Testing
- Swept-Source Optical Coherence Tomography (SS-OCT), Orange Juice Erosive Challenge, Sugar-Free Chewing Gum Stimulation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Dental Erosion
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive.
- Trial name
- NCT06171594
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Tooth Erosion
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra orally using a palatal appliance and…
- Trial name
- NCT03296072
- Testing
- 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Obesity, Childhood
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
Objectives To compare oral health (dental caries, periodontal status, and erosive tooth wear (ETW)), diet and oral hygiene habits between obese and normal weight adolescents, and to explore possible risk associations.
- Conditions
- Obesity, Obesity, Childhood, Tooth Wear, Tooth Erosion
- Trial name
- NCT05146557
- Testing
- Dental examination
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Eating Disorders, Oral Health
Oral Indicators for ED Screening
The main objective of this research project is to explore the capability of a standardized, evidence-based study tool (the OHEDs Checklist) in the early identification of oro-dental manifestations potentially indicative of an…
- Conditions
- Eating Disorders, Oral Health, Eating Disorders Symptoms
- Trial name
- OHEDS (NCT07295197)
- Where
- Italy
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Bologna