Clinical trials: Dental Occlusion
Stenosis of Artery, Peripheral Arterial Disease
The Merit WRAPSODY™ Endovascular Stent Graft for Treatment of Iliac Artery Occlusive Disease
This is a prospective, single-center, non-randomized phase 2, first-in-iliac artery study, to evaluate the safety and effectiveness of the WRAPSODY Stent Graft for the treatment of peripheral arterial occlusive disease in…
- Conditions
- Stenosis of Artery, Peripheral Arterial Disease, Iliac Artery Disease, Iliac Artery Occlusion
- Trial name
- NCT03994185
- Testing
- Placement of WRAPSODY stent graft
- Sponsor
- Merit Medical Systems, Inc.
Ischemic Stroke, Small Vessel Cerebrovascular Disease
Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke
Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels…
- Conditions
- Ischemic Stroke, Small Vessel Cerebrovascular Disease, Cholesterol, LDL, Secondary Prevention
- Trial name
- SVO70 (NCT06649240)
- Testing
- Statins and/or Ezetimibe, PCSK9 inhibitor
- Where
- 46 sites in South Korea
- Volunteers
- 4,016 people
- Sponsor
- Seoul National University Hospital
Intracranial Pressure, Intracranial Pressure Changes
Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein
Elevated intracranial pressure is a common complication of brain injury which means that the pressure within the skull rises above normal levels.
- Trial name
- NCT07222826
- Testing
- CPMX3
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Compremium AG
Recognition of Thrombectomy Candidate
Implementation of Finnish Prehospital Stroke Scale to Emergency Medical Services
The investigators have developed a simple prehospital stroke scale (FPSS), containing 5 dichotomized items to recognize both large and small artery thrombi of the brain.
- Trial name
- NCT03520335
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Amblyopia, Amblyopia Occlusion
Rehabilitation Training Games for Children With Amblyopia
A gamification product was developed to guide children with amblyopia to develop rehabilitation training habits by combining cognitive evaluation theory and occlusion therapy.
- Conditions
- Amblyopia, Amblyopia Occlusion, Child Behavior, Adherence, Treatment
- Trial name
- NCT06372548
- Testing
- Find You! Cure My Animal Friends, DuoBao Vision Training System
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Zhu Dian
Coronary Artery Disease
A-priori Versus Provisional Heparin on Radial Artery Occlusion After Transradial Coronary Angiography and Patent Hemostasis
The Provisional Heparin TherApy on Radial Artery Occlusion after transradial coronary angiography and patent Hemostasis (PHARAOH) study compares the strategy of standard a-priori heparin use in patients undergoing transradial…
- Trial name
- PHARAOH (NCT01489917)
- Testing
- Patent hemostasis and heparin
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 428 people
- Sponsor
- Olivier F. Bertrand
Symptomatic Chronic Middle Cerebral Artery Occlusion, Infarction, Middle Cerebral Artery
Extracranial-intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion: the CMOSS-2 Trial
The CMOSS-2 trial is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit symptomatic chronic occlusion of the middle cerebral artery in patients with severe hemodynamic insufficiency.
- Trial name
- NCT05899582
- Testing
- Extracranial-Intracranial Bypass Surgery, Medical treatment alone
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Xuanwu Hospital, Beijing
Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD
A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
The purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal…
- Conditions
- Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD, Double Outlet Right Ventricle, Subaortic VSD, Double Outlet Right Ventricle, Subpulmonary VSD
- Trial name
- NCT02361008
- Testing
- TEE-guided perventricular device closure without CBP, Surgery repair with CBP
- Where
- China
- Volunteers
- 20,121,212 people
- Sponsor
- Bentong Yu
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- NCT03980717
- Testing
- Goldbal Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Michael A Belfort
Branch Retinal Vein Occlusion
601 Versus Ranibizumab in Patients With Branch Retinal Vein Occlusion (BRVO)
To evaluate the safety and efficacy of intravitreal recombinant humanized anti-VEGF monoclonal antibody in patients with visual impairment due to macular edema secondary to BRVO
- Trial name
- NCT04667897
- Testing
- 601 1.25mg, Ranibizuman 0.5 mg
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.
Retinal Disease
Study to Gather Information on the Safety and Use of Aflibercept Injections Into the Eye for the Treatment of Eye Disorders in Mexican Routine Clinical Practice
The study aims to collect data on the safety and use of intravitreal aflibercept injections into the eye for the treatment of eye disorders that cause blurred vision or a blind spot due to abnormal or blocked blood vessels.
- Trial name
- MAIA (NCT04137120)
- Testing
- Aflibercept (BAY86-5321, Eylea)
- Where
- Mexico
- Volunteers
- 73 people
- Sponsor
- Bayer
Peripheral Vascular Diseases
Clinical Study on the Effectiveness and Safety Evaluation of Directional Atherectomy Combined With Drug-coated Balloons
DCB can maximize the patency rate of blood vessels on the basis of intraluminal DA. DA+DCB treatment is effective and safe [8], and the advantages of DA and DCB in the treatment of severe calcification and occlusive disease…
- Trial name
- Remove (NCT04986098)
- Testing
- TurboHawk, Paclitaxel
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Occlusion
Effect of Mandibular Complete Dentures Relining on Occlusal Force Distribution
evaluation of occlusal force distribution was carried out with the aid of T-Scan device (Tekscan Inc., South Boston, MA, USA) for mandibular complete dentures before and after relining with long term soft liner for controlled…
- Trial name
- NCT04701970
- Testing
- relining of mandibular complete denture
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- National Research Centre, Egypt
Dental Caries, Endodontically Treated Teeth
Clinical Evaluation of Posterior Indirect Adhesive Restorations
Clinical performance of indirect adhesive restorations - onlays, overlays- luted with light-cured composite resin will be evaluated over three years.
- Conditions
- Dental Caries, Endodontically Treated Teeth, Dental Restoration Failure of Marginal Integrity, Wear, Occlusal
- Trial name
- NCT04293770
- Testing
- Indirect adhesive restoration of posterior teeth
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Okan University
Femoral Artery Stenosis, Femoral Artery Occlusion
A Single Arm Trial Evaluating the BARD Lutonix Drug-Coated Balloon (LTX DCB) for Treatment of Femoropopliteal Arteries
To assess the safety and efficacy of the BARD LTX DCB for treatment of stenosis or occlusion of the superficial femoral and popliteal arteries.
- Conditions
- Femoral Artery Stenosis, Femoral Artery Occlusion, Stenosis of Popliteal Arteries, Occlusion of Popliteal Arteries
- Trial name
- NCT02720003
- Testing
- LTX DCB
- Where
- 14 sites in China
- Volunteers
- 148 people
- Sponsor
- C. R. Bard
Acute Ischemic Stroke
Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT07389460
- Testing
- Intravenous rhPro-UK, Endovascular thrombectomy
- Where
- 10 sites in China
- Volunteers
- 820 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke, Ischemic Attack, Transient
Carotid Occlusion Surgery Study
The purpose of this study is to determine if extracranial-intracranial bypass surgery when added to best medical therapy can reduce the subsequent risk of ipsilateral stroke in high-risk patients with recently symptomatic carotid…
- Conditions
- Stroke, Ischemic Attack, Transient, Cerebral Infarction
- Trial name
- COSS (NCT00029146)
- Testing
- extracranial-intracranial bypass surgery, best medical therapy
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of North Carolina, Chapel Hill
Occlusion of Artery
Prevention of Radial Artery Occlusion: Prophylactic Hyperperfusion Evaluation Trial
Evaluating the effect of ulnar artery compression while pressing on radial artery to stop bleeding, in maintaining radial artery potency, after cardiac catheterization through the radial artery.
- Trial name
- PROPHET-II (NCT01564888)
- Testing
- Ulnar artery compression
- Where
- 2 sites in Czechia, India
- Volunteers
- 3,000 people
- Sponsor
- Total Cardiovascular Solutions
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