Clinical trials: Dental Pulp Disease
Dental Pulp Diseases
Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four
A two-tailed randomized controlled trial with two parallel arms is aimed to compare success proportions of the articaine and lidocaine groups in children with irreversible pulpitis under 4 years.
- Trial name
- NCT05944341
- Testing
- articaine hydrochloride 4% with epinephrine 1:100 000, Lidocaine hydrochloride 2% with epinephrine 1:100 000
- Where
- Egypt
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Minia University
Endodontic Disease, Endodontic Inflammation
Analysis of Bacterial Microbiome of Endodontically Infected Primary and Permanent Teeth
Recognition of community profiles in endodontic infections may allow a better understanding of the pathogenesis of the disease and the establishment of more effective treatment protocols.
- Trial name
- NCT04211519
- Testing
- sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Nuh Naci Yazgan University
Dental Pulp Regeneration, Dental Pulp Diseases
Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which…
- Trial name
- NCT00595595
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dental Caries in Children, Dental Diseases
Articaine Efficacy and Safety for 3 Years Old Children
The primary purpose of this study is to determine the local anesthetic efficacy and safety of 4% Articaine compared 2% Mepivicaine in 3 years old children, by using infiltration technique for primary teeth that required…
- Conditions
- Dental Caries in Children, Dental Diseases, Pulp Disease, Dental, Behavior, Child
- Trial name
- NCT05839548
- Testing
- Mepivacaine 2% with epinephrine 1:100,000, Articaine (4%) with epinephrine 1:100,000
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Qassim Health Cluster
Periodontitis, Localized Aggressive, Periodontal Diseases
Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket
The aim of this study is to evaluate the accuracy of pulp test in teeth presenting with deep periodontal pocket. The null hypothesis is no significant effect of periodontitis on the accuracy of pulp test.
- Conditions
- Periodontitis, Localized Aggressive, Periodontal Diseases, Endodontic Disease, Endodontic Inflammation
- Trial name
- NCT04399135
- Testing
- Orthopantomogram X-ray view, Endo-Ice, Electric Pulp Tester (EPT)
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qassim University
Pulpitis, Apical Periodontitis
Validation of PUFA Index in Assessing Untreated Dental Caries Among Malaysian Adult Subpopulation
PUFA Index was introduced to detect the clinical consequences of untreated dental caries. To date, there are no studies on the reliability and accuracy of the PUFA index as a screening tool.
- Trial name
- NCT04126928
- Testing
- Screening using DMFT and PUFA, orthopantomogram is taken and assessed using PAI, comprehensive clinical examination to diagnose pulpal and periapical conditions.
- Where
- Malaysia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Regenerative Endodontics in Traumatized Immature Teeth
Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis
Endodontic management of traumatized immature permanent teeth with pulp necrosis is both a clinical challenge for the dental practitioners and a public health care problem.
- Trial name
- NCT04000854
- Testing
- Calcium hydroxide (Calacept)
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Karolinska Institutet
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulp Necrosis, Apical Periodontitis
CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth
This pilot clinical study evaluated the clinical, radiographic, and functional outcomes of autologous pulp transplantation combined with concentrated growth factor (CGF) in mature permanent teeth with pulp necrosis and periapical…
- Trial name
- CGF-PULP (NCT07314866)
- Testing
- Autologous Pulp Transplantation With Concentrated Growth Factor
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Endodontically Treated Teeth
A 3-Year Clinical Evaluation Of Endocrown Restorations With Two Different Materials
The clinical performance of two different materials in endodontically treated teeth produced with CAD/CAM system will be evaluated and compared.
- Trial name
- NCT06311422
- Testing
- resin nanoceramic block, zirconia-reinforced lithium silicate
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Endodontically Treated Teeth
Composite Restorations Performed by Placing Polyethylene Fiber
This study aimed to evaluate the 12-month clinical performance of direct composite restorations by placing polyethylene fibers in different directions in endodontically treated posterior teeth.
- Trial name
- NCT06346769
- Testing
- Polyethylene Fiber
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Endodontically Treated Teeth, Tooth Discoloration
Color Dental Alteration Caused by Endodontic Treatment
The color change of endodontically treated teeth is a common concern in clinical practice. The objective of this study will be to evaluate, in vivo, the color change (ΔE00) caused by endodontic treatment.
- Conditions
- Endodontically Treated Teeth, Tooth Discoloration, Root Canal Infection
- Trial name
- NCT03841877
- Testing
- endodontic treatment
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pulp Necrosis, Apical Periodontitis
The Effect of Different Intra-canal Medications on Postoperative Pain
The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients…
- Trial name
- NCT07603934
- Testing
- ibuprofen, Nitrofurantoin, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Avocado
Clinical Investigation on the Safety of Avocado Pulp Lipids
Obesity and diabetes are a significant global burden and there is an immediate need for novel treatments and management strategies.
- Conditions
- Obesity, Avocado, Overnutrition, Nutritional Disorder
- Trial name
- NCT03898505
- Testing
- AvoMax (Low Dose), AvoMax (High Dose)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Postoperative Pain, Endodontic Disease
Post-endodontic Pain Survey
As part of root canal treatment, canals should be sealed to prevent further contaminations. There are multiple accepted techniques to fill-obturate canals. In the past, different obturation techniques have been compared.
- Conditions
- Postoperative Pain, Endodontic Disease, Obturation
- Trial name
- NCT04462731
- Testing
- Non-surgical root canal treatment filled with WVT, Non-surgical root canal treatment filled with SBT
- Volunteers
- 194 people
- Sponsor
- Ya-Hsin Yu, DDS, MS
Endodontic Inflammation, Pulp Disease, Dental
Evaluation of Clinical and Radiological Success of Vital Amputation Treatment
Total amputation therapy; is a treatment method aimed at maintaining the vitality of the radicular pulp remaining as a result of complete removal of coronal pulp tissue.
- Trial name
- NCT03883295
- Testing
- Control, NeoMTA Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Apical Periodontitis, Pulp Disease, Dental
In Vivo-Ex Vivo Evaluation of the Root ZX3 for Working-Length Determination
This study evaluates the accuracy and repeatability of the Root ZX3 electronic apex locator for determining root canal working length in single-rooted permanent teeth requiring extraction.
- Trial name
- NCT07689838
- Testing
- Root ZX3 Electronic Apex Locator
- Where
- Saudi Arabia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Tooth, Nonvital, Composite Resins
Post-retained Restorations for RPD Abutments
This study will be a controlled, randomized, parallel group trial where the survival rate of direct and indirect restorations on removable partial denture abutment teeth will be assessed.
- Conditions
- Tooth, Nonvital, Composite Resins, Metal Ceramic Restorations, Denture, Partial, Removable
- Trial name
- NCT03466437
- Testing
- Glass-fiber post and composite resin restoration, Glass-fiber post and metalceramic crown, Cast-metal post and metalceramic crown
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas