Clinical trials: Dental Pulp Necroses
Necrotic Pulp With Symptomatic Apical Periodontitis
Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication .
Calcium hydroxide is advocated as an intracanal medication for various purposes, including prevention of post-treatment symptoms.
- Trial name
- NCT05021809
- Testing
- Calcium hydroxide intracanal medication application
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Pulp Necrosis, Apical Periodontitis
Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods
This randomized clinical trial aims to evaluate the antibacterial efficacy and treatment outcomes of three different final irrigation protocols during root canal therapy: 2.5% sodium hypochlorite alone, sodium hypochlorite with…
- Conditions
- Pulp Necrosis, Apical Periodontitis, Endodontic Treatment
- Trial name
- ENDOABG (NCT06959602)
- Testing
- Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- National and Kapodistrian University of Athens
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Pulp Necroses
The Efficacy and Safety of Pulp Regeneration Induced by SHED Polymerization
Dental pulp necrosis is one of the most common pathological conditions that results in tooth loss. However, regeneration of functional dental pulp has proved difficult.
- Trial name
- NCT05728346
- Testing
- Allogeneic human pulp mesenchymal stem cells mixed with hyaluronic acid polymers
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital of Guangzhou Medical University
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Dental Pulp Necroses, Tooth, Nonvital
Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis
This randomized controlled clinical trial evaluated the immediate reduction in intracanal microbial load and the short-term clinical and radiographic progression of anterior primary teeth with pulp necrosis after conventional…
- Trial name
- NCT02485210
- Testing
- Conventional Endodontic Treatment, Antimicrobial Photodynamic Therapy
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- University of Nove de Julho
Dental Pulp Necrosis, Disorder of Tooth Development
A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation
Both methods tested in this study disinfect the non-vital root canals and induce blood clot formation inside the root canal. One method places calcium hydroxide inside the root canal after disinfection and the blood clot is…
- Trial name
- NCT01827098
- Testing
- Endodontic Regeneration
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Michigan
Apical Periodontitis, Pain
One vs Two Visits Root Canal Treatments in Infected Teeth
The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment.
- Conditions
- Apical Periodontitis, Pain, Tooth Loss, Dental Pulp Necrosis
- Trial name
- NCT04605445
- Testing
- 1 visit root canal treatment (endodontics), 2 visits root canal treatment (endodontics)
- Where
- 7 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Malmö University
Pulp Necrosis, Irreversible Pulpitis
CLINICAL AND RADIOGRAPHIC SUCCESS OF MODIFIED LSTR TECHNIQUES IN PRIMARY SECOND MOLARS
This study aimed to evaluate and compare the clinical and radiographic success of different antibiotic and vehicle modifications of the Lesion Sterilization and Tissue Repair (LSTR) technique in infected mandibular primary second…
- Trial name
- NCT07836686
- Testing
- 3Mix-MP Antibiotic Paste, 3Mix-NS Antibiotic Paste, 2Mix-MP Antibiotic Paste
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Uşak University
Necrotic Pulp
Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp.
- Trial name
- NCT07327996
- Testing
- Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necrosis
The Effect of Sealer Type and Obturation Technique on Postoperative Pain
Postoperative pain is an important consideration in endodontic treatment, and its incidence may be influenced by both obturation technique and sealer type.
- Trial name
- pain (NCT07386197)
- Testing
- Obturation of root canals
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Pulpal Necrosis
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment…
- Trial name
- NCT07210359
- Testing
- human treated dentin matrix hydrogel, Theracal LC - Demineralized dentin matrix combination, Retro Mta
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Pulp Disease, Dental, Pulp Mummification
Lasers as an Alternative to Formocresol and Sodium Hypochlorite Medicaments in Pulpotomy Techniques
The goal of this clinical trial is to evaluate the dental lasers as an alternative of chemical medicaments used in the pulpotomy procedures.
- Trial name
- NCT06002646
- Testing
- Formocresol, Sodium Hypochlorite Solution, Diode laser
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- University of Sulaimani
Dental Pulp Necrosis
Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth
The aim of this study is to compare the effect of antimicrobial-corticosteroid mixture and cryotherapy as final root canal irrigating solutions on post-instrumentation pain in single-canal teeth with necrotic pulps.
- Trial name
- MIXCRYO (NCT05739682)
- Testing
- Local anaesthetic injection of 4% articaine with 1:100000 epinephrine, Tooth isolation, Access cavity preparation
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Pulp Necrosis
Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth
the objective of this study is to evaluate post operative pain after using Endosequence versus Mineral Trioxide Aggregate as coronal plug material in revascularization of non vital immature anterior teeth
- Trial name
- NCT03813433
- Testing
- Revascularization
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Necrotic Pulp, Postoperative Pain
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy
The aim of the current study is to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN \& will be compared to…
- Trial name
- 3-mixtatin (NCT03084601)
- Testing
- Calcium Hydroxide, Iodoform, paste, 3-mixtatin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahmoud M Saadoon
Necrotic Pulp, Post Operative Pain
Effect of Vachellia Nilotica Versus Sodium Hypochlorite as Root Canal Irrigant on Postoperative Pain and Bacterial Load Reduction in Mandibular Premolar Teeth With Necrotic Pulp
The aim of this study is to assess the effect of V. nilotica extract solution versus 2.5% NaOCl on the intensity of postoperative pain and the amount of bacterial load reduction.
- Trial name
- NCT06116214
- Testing
- Vachellia Nelotica, sodium hypochlorite
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp
Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth
The maintenance of the deciduous tooth until its physiological exfoliation occurs is one of the main objectives of pediatric dentistry.
- Trial name
- NCT04587089
- Testing
- Irrigation, Filling with Guedes-Pinto Paste, Filling with CTZ Paste
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho