Clinical trials: Dental Treatment
Dental Pain
Study of Buprenorphine HCl Buccal Film in the Treatment of Dental Pain
The purpose of this study is to assess the activity of buprenorphine hydrochloride (HCl) buccal film in the treatment of dental pain.
- Trial name
- NCT00941304
- Testing
- Oxycodone, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- BioDelivery Sciences International
COVID-19
Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells
Evaluation of novel coronavirus induced severe pneumonia by dental pulp mesenchymal stem cells
- Trial name
- NCT04302519
- Testing
- Dental pulp mesenchymal stem cells
- Volunteers
- 24 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
Acute Pain
Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction
The objective of this study is to evaluate the analgesic efficacy and safety of ADL5859 compared with placebo and an active control (ibuprofen) in subjects with acute dental pain after third molar extraction.
- Trial name
- NCT00993863
- Testing
- ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Periodontitis, Plaque, Dental
Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health
This early-stage study is designed to determine the efficacy of the CE-approved, antibacterial, dual-light Lumoral method in periodontitis patients.
- Conditions
- Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05361590
- Testing
- Lumoral device
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Dental Plaque
Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
The objective of the study is to evaluate anti-plaque efficacy of a preventive treatment gel in a modified 4-day plaque model.
- Trial name
- NCT03546491
- Testing
- Preventive Gel, Marketed Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Class I Dental Restorations, Class II Dental Restorations
Clinical Evaluation of a New Dual-cure Universal Adhesive
The overall aim of this study is to evaluate the clinical performance and safety of the new dental dual-cure adhesive for luting indirect ceramic restorations (inlays and onlays).
- Conditions
- Class I Dental Restorations, Class II Dental Restorations, Insufficient Dental Restoration, Caries, Dental
- Trial name
- NCT06615544
- Testing
- Placement of indirect dental restoration
- Where
- Liechtenstein
- Volunteers
- 45 people
- Sponsor
- Ivoclar Vivadent AG
Anesthesia
Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth
The purpose of this study is to compare the efficacy of Kovacaine Mist, Tetracaine only, and Placebo for inducing pulpal anesthesia of the maxillary teeth in adults.
- Trial name
- NCT01660893
- Testing
- Tetracaine HCl 3% and oxymetazoline HCl 0.05%, Tetracaine HCl 3%
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- St. Renatus, LLC
Acute Pain
A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Primary objective: To assess the efficacy of OKITASK® 40 mg granules versus Placebo in patients with acute pain syndrome after removal of one molar tooth by comparing AUC0-6h of posttreatment pain profile measured by VAS.
- Trial name
- KSL0117 (NCT03836807)
- Testing
- OKITASK®
- Where
- 3 sites in Russia
- Volunteers
- 70 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Post-surgical Dental Pain
Efficacy Of Pf-04531083 In Treating Post-Surgical Dental Pain
The purpose of this study is to evaluate the overall pain relief of a single dose of PF-04531083 against placebo following third molar extraction.
- Trial name
- NCT01512160
- Testing
- PF-04531083, Ibuprofen
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Pfizer
Dental Pain
Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars
To evaluate the efficacy of a single dose NTC-510 or NTC-510A for dental pain following third molar extraction.
- Trial name
- NCT02161354
- Testing
- NTC-510 capsules, NTC-510A Capsules
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NanoSHIFT LLC
Acute Pain, Post Operative Pain
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
MR-107A-02 is being studied to investigate its efficacy, safety and dose-response after dental surgery.
- Conditions
- Acute Pain, Post Operative Pain, Pain
- Trial name
- NCT05317312
- Testing
- MR-107A-02
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Mylan Specialty, LP
Snoring, Apnea, Obstructive
Dental Appliance to Treat SDB in Children
The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.
- Conditions
- Snoring, Apnea, Obstructive, Upper Airway Resistance Syndrome, Sleep-Disordered Breathing
- Trial name
- NCT05661747
- Testing
- Vivos Grow/Vivos Way Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vivos BioTechnologies, Inc.
Caries Infiltration, Fluorosis
Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Dental fluorosis is a clinical manifestation of chronic exposure to high intakes of fluoride during the tooth development. The present study is planned to evaluate the efficacy of Resin Infiltration technique in improving the…
- Conditions
- Caries Infiltration, Fluorosis, Dental Care
- Trial name
- NCT01733888
- Testing
- Office Bleaching, Resin Infiltration, Resin Infiltration twice
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Tooth Extractions
Study of Hemostatic Efficacy of the HemCon Dental Dressing in a Population Treated With Anticoagulant Medications
The purpose of this study is to determine if the HemCon Dental Dressing is effective in stopping bleeding during dental surgeries in patients taking anticoagulant medications.
- Trial name
- NCT00707564
- Testing
- HemCon Dental Dressing, Gauze with pressure
- Where
- 2 sites in United States
- Sponsor
- HemCon Medical Technologies, Inc
Dental Devices, Home Care
Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
This study is 6 weeks long with 6 visits to a clinical site. People participating in this study will be asked to brush their teeth two times a day with a provided toothbrush.
- Trial name
- NCT01224158
- Testing
- Experimental Power Toothbrush, Flat trimmed Manual Toothbrush
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Focal Infection, Dental
AUGMENTIN™ in Dental Infections
In clinical practice, amoxicillin + clavulanic acid is widely used in the treatment of odontogenic infection. Therefore, this study is designed to generate data to support its use by demonstrating efficacy, safety and…
- Trial name
- AUGDENT (NCT02141217)
- Testing
- Amoxicillin/clavulanate, Clindamycin
- Where
- 15 sites in Malaysia, Philippines and 2 more
- Volunteers
- 472 people
- Sponsor
- GlaxoSmithKline
Dental Plaque
Dental Plaque Removal Ability of Prototype Power Toothbrush Versus a Manual Toothbrush in Healthy Participants
The aim of this study is to evaluate the ability of a prototype power toothbrush (PTB) versus a manual toothbrush in healthy, right-handed manual toothbrush (MTB) participants with no signs of periodontal disease or excessive…
- Trial name
- NCT03809910
- Testing
- Reference MTB, Reference PTB, Prototype PTB (Gum line mode)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Anxiety
Trial of Pregabalin, Alprazolam, and Placebo in Subjects With Anxiety Prior to Dental Procedure
The primary purpose of the trial is to assess how effective pregabalin, alprazolam, and placebo are at reducing anxiety levels of subjects who take a dose of these treatments 4 hours before a scheduled dental procedure.
- Trial name
- NCT00245609
- Testing
- Pregabalin, Alprazolam
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 90 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Dental Atraumatic Restorative Treatment
Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
The investigator will review the medical history taken by the participants' orthodontist that determined participants eligibility to participate in this study on the first appointment.
- Trial name
- NCT07165366
- Testing
- Carbamide Peroxide 10%, Hydrogen Peroxide
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ultradent Products, Inc.