Clinical trials: Dental Treatment
Pulpal Inflammation
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care
Background: Vital pulp therapy (VPT) is a cornerstone of minimally invasive dentistry and aims to preserve pulp vitality whenever clinically feasible.
- Trial name
- INFLAPULP (NCT07533396)
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dental Pulp Exposure, Postoperative Pain
Diode Laser-Assisted Direct Pulp Capping Trial
This randomized controlled clinical trial evaluates whether adjunctive 808-nm diode laser therapy after direct pulp capping reduces postoperative pain and dentin hypersensitivity compared with conventional Biodentine treatment.
- Conditions
- Dental Pulp Exposure, Postoperative Pain, Dentin Hypersensitivity
- Trial name
- NCT07593508
- Testing
- Biodentine, 808-nm Diode Laser
- Where
- Vietnam
- Volunteers
- 56 people
- Sponsor
- Hue University of Medicine and Pharmacy
Apexification, Root Canal Therapy
Antimicrobial Pastes and Clinical Cases of Apexogenesis
The aim of this study was to perform a clinical and microbiological evaluation of teeth with incomplete apexogenesis and traumatic necrosis that were treated with a revascularization technique, evaluating the microbial reduction…
- Conditions
- Apexification, Root Canal Therapy, Dental Trauma
- Trial name
- NCT03112291
- Testing
- Apexification
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Adriana Kelly de Sousa Santiago Barbosa
Gingivitis and Periodontal Diseases, Dental Plaque
0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis
Gingivitis is the most common form of reversible gum disease, caused by the accumulation of dental plaque. It leads to inflammation of the gums, bleeding, and discomfort, but it can be managed and reversed with professional…
- Conditions
- Gingivitis and Periodontal Diseases, Dental Plaque, Oral Hygiene
- Trial name
- GEM-CHX02 (NCT07088666)
- Testing
- MicroRepair ABX mouthwash, Chlorhexidine 0.2% mouthwash
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Periodontal Health, Endodontically Treated Teeth
Deep Margin Elevation in Endodontically Treated Posterior Teeth
This study aims to evaluate the periodontal response of proximal surfaces with deep margin elevation (DME) in endodontically treated posterior teeth restored with CAD/CAM systems.
- Trial name
- DME-PERIO (NCT07661719)
- Testing
- Deep Margin Elevation, CAD/CAM Restoration Without DME
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Temporomandibular Disorders (TMD)
The Effect of Manual Physical Therapy and Exercise in Addition to Routine Dental Care in Individuals With Temporomandibular Disorders
The goal of this randomized clinical trial among US military active-duty service-members with temporomandibular disorders (TMD) is to determine whether standard care plus 6-weeks of tailored, individualized physical therapy (PT)…
- Trial name
- NCT06602375
- Testing
- Standard care, Physical Therapy (PT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brooke Army Medical Center
Dental Anxiety, Dental Phobia
Virtual Reality Distraction for Dental Anxiety (PILOT)
Introduction. Dental fear and anxiety (DFA) is a condition that affects approximately a quarter of children and adolescents. Lack of patient cooperation due to DFA can create an environment of stress, often obligating dentists to…
- Conditions
- Dental Anxiety, Dental Phobia, Dental Trauma, Dental Diseases
- Trial name
- NCT05898100
- Testing
- Virtual Reality Distraction, Dental Clinic's Standard Treatment
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- St. Justine's Hospital
Dental Caries
The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances
This study investigates how often cavities develop on the permanent teeth of patients with braces (orthodontic treatment). The hypothesis is that there is no difference in the number of cavities on the permanent teeth of patients…
- Trial name
- WSLs (NCT04186065)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hiroko Nagaoka
Endodontically Treated Teeth
Effect of TruNatomy and HyFlex EDM Instrumentation on Postoperative Pain
The aim of the present study is to clinically compare the incidence of postoperative pain after root canal preparation using TruNatomy system and HyFlex Electrical Discharge Machined (EDM) rotary system in asymptomatic necrotic…
- Trial name
- TRN (NCT05289973)
- Testing
- TruNatomy Files, HyFlex EDM Files
- Volunteers
- 36 people
- Sponsor
- Cairo University
Dental Restoration Failures
An In-vivo Survival Rate of Different Onlay Materials Placed Over Endodontically Treated Molar Teeth
This study aims to evaluate the survival rates of onlays placed over posterior endodontically treated teeth restored with zirconia, lithium disilicate and lithium disilicate reinforced with zirconia.
- Trial name
- NCT07753941
- Testing
- Monolithic zirconia partial coverage onlays, Lithium disilicate partial coverage onlays, zirconia-reinforced lithium disilicate partial coverage onlays
- Where
- Jordan
- Volunteers
- 39 people
- Sponsor
- Yousef Mahmoud Salem
Dental Anxiety
Testing of Cognitive Behavioral Therapy Resource of Turkish Version
This study aimed to evaluate the cognitive behavioral therapy source of Turkish version of the 'message to dentist' (MTD) with children attending two dental settings.
- Trial name
- NCT05285722
- Testing
- Cognitive Behavioral Therapy form for dental anxiety
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Altinbas University
Dental Plaque, Dental Care
Effectiveness of Theobromine Toothpaste
Since plaque control forms the basis for caries prevention, the type of toothpaste and its constituents becomes more important. Toothpaste containing fluoride are widely popular and fluorides have been historically reported to…
- Trial name
- NCT05187507
- Testing
- Evaluation of the effectiveness of low- fluoridated toothpaste., Evaluation of the effectiveness of fluoridated toothpaste., Evaluation of the effectiveness of theobromine toothpaste (2%) toothpaste.
- Where
- Syria
- Volunteers
- 80 people
- Sponsor
- Damascus University
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Perioperative Anxiety, Preanesthetic Medication
Handheld-multimedia Versus Oral Midazolam in Pediatric on Perioperative Anxiety
The first goal of this study is to compare the efficacy and safety between anxiolysis by multimedia-distraction with an IPAD versus anxiolysis by premedication with midazolam prior to the induction.
- Conditions
- Perioperative Anxiety, Preanesthetic Medication, Inhalation Anesthesia, Ambulatory Surgery
- Trial name
- NCT04273035
- Testing
- Midazolam oral solution, IPAD
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Dental Anxiety, Pain Management
Impact of Local Anesthesia Techniques on Children's Dental Treatment Experience
compare the effectiveness of several local anesthetic delivery systems in managing pain, anxiety, behavior, and vital signs among pediatric dental patients.
- Conditions
- Dental Anxiety, Pain Management, Pediatric Dentistry
- Trial name
- NCT07106138
- Testing
- Conventional syringe injection, Star Pen, Comfort-In
- Where
- Syria
- Volunteers
- 112 people
- Sponsor
- Latakia University
MEDICATION RELATED OSTEONECROSIS OF THE JAW
OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is also a potentially painful and debilitating condition.
- Trial name
- OZONE_EXO (NCT06072404)
- Testing
- OxigenOzone_Insufflation
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Dental Caries
Effectiveness of Atraumatic Restorative Treatment Using Glass Ionomer Cement of Different Costs
Atraumatic Restorative Treatment (ART) is an alternative restorative technique for dental caries, applying the partial caries tissue removal philosophy using hand instruments, relative cotton rolls isolation, immediate…
- Trial name
- SLM1797 (NCT02778503)
- Testing
- High Cost, Low Cost
- Where
- Brazil
- Volunteers
- 574 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Child Autism
Effect of Modified Dental Visual Aids on Behavior Management During Dental Treatment in Children With Autism Spectrum Disorder
There is a need to find an approach that is appropriate for managing children with Autism Spectrum Disorder in the dental clinic, to manage their behaviour and decrease their anxiety in this research we will apply our modified…
- Trial name
- NCT04576559
- Testing
- Modified dental visual aids, Regular dental visual aids
- Where
- Saudi Arabia
- Volunteers
- 64 people
- Sponsor
- King Abdulaziz University
Dental Malocclusion
Maxillary Versus Bi-Maxillary Posterior Segments Intrusion Adult Subjects With Skeletal Open Bite
Compare between bi-maxillary (maxillary and mandibular) posterior dento-alveolar intrusion and maxillary posterior dento-alveolar intrusion as regards open bite closure.
- Trial name
- NCT04713280
- Testing
- Maxillary posterior dento-alveolar intrusion
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Anxiety
Animal Assisted Therapy in Pediatric Dentistry
A prospective randomized trial measuring physiologic biometrics and perceptions of stress during a pediatric dental exam, cleaning, and simulated radiographs with or without a therapy dog present.
- Trial name
- AAT (NCT05464888)
- Testing
- +Short AAT, +Long AAT, Active control; NO dog
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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