Clinical trials: Dental Treatment
DENT IMPLANTS, LASER
Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
The purpose of this study is to compare clinical outcomes (change in bleeding sites (BOP) and probing depth reduction (PPD) after mechanical debridement of implant surfaces at sites exhibiting plaque induced inflammation with or…
- Trial name
- NCT04187053
- Testing
- Conventional mechanical therapy, Saline, Methylene Blue
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cigarette Smoking
Free Samples for Health
The Free Samples for Health (FreSH) study tests whether providing free samples of stop smoking medicine called nicotine replacement therapy at dental visits results in a greater number of people quitting smoking than providing a…
- Trial name
- FreSH (NCT05627596)
- Testing
- Ask-Advise-Refer, Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release, Nicotine lozenge
- Where
- United States
- Volunteers
- 1,239 people
- Sponsor
- Sandra Japuntich
Huntington Disease
Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease
Cellavita HD is a stem-cell therapy for Huntington's Disease. This is a prospective, phase II, single-center, randomized (2:2:1), triple-blind, placebo controlled study, with two test doses of Cellavita HD product.
- Trial name
- ADORE-DH (NCT03252535)
- Testing
- Cellavita HD lower dose, Cellavita HD higher dose
- Where
- Brazil
- Volunteers
- 49 people
- Sponsor
- Azidus Brasil
Conscious Sedation
Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care
The general objective of the study is to compare the efficacy of administering midazolam orally as syrup versus nasally with nasal atomizer.
- Trial name
- NCT02679781
- Testing
- oral midazolam, nasal midazolam
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Dental Caries
Providers Against Cavities in Children's Teeth
The study is a multi-site, multi-level, and multi-component cluster randomized clinical trial (RCT) to address poor dental utilization (attendance) and untreated caries among 3-6 year old Medicaid-enrolled children attending…
- Trial name
- PACT (NCT03385629)
- Testing
- CSM theory-based didactic education and skills training, AAP-based didactic education, Practice EMR changes
- Where
- United States
- Volunteers
- 2,108 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery
The present study is proposed to evaluate the efficacy and safety of single doses of Diclofenac HPBCD subcutaneous (s.c.) (25 mg/1 ml and 50 mg/1 ml) in the treatment of acute moderate-to-severe pain after dental impaction…
- Trial name
- NCT00942448
- Testing
- Diclofenac HPBCD
- Where
- 6 sites in Poland, United Kingdom
- Volunteers
- 306 people
- Sponsor
- IBSA Institut Biochimique SA
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Dental Plaque
Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
The objective of the study is to evaluate anti-plaque efficacy of a preventive treatment gel in a modified 4-day plaque model.
- Trial name
- NCT03546491
- Testing
- Preventive Gel, Marketed Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Tooth Extraction
Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction
In patients treated with direct oral anticoagulants, bleeding events during or after tooth extraction can lead to unscheduled interruption of the antithrombotic treatment and a potential increased risk of thrombo-embolic events.
- Trial name
- EXTRACT-NOAC (NCT03413891)
- Testing
- Tranexamic Acid
- Where
- Belgium
- Volunteers
- 222 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Irreversible Pulpitis, Apical Periodontitis
Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis
Statement of problem: Although performing full pulpotomy in mature permanent molars with irreversible pulpitis showed success rates comparable to RCT, there is a growing need for further studies in order to determine the…
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpitis
- Trial name
- NCT06767371
- Testing
- Patients with mature permanent molars diagnosed with severe pulpitis with apical periodontitis to be treated with full pulpotomy., Patients with mature permanent molars diagnosed with moderate pulpitis without apical periodontitis to be treated with full pulpotomy., Teeth with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Misr International University
Dental Pain
Phase 2 Study of Indomethacin Capsules to Treat Dental Pain
The purpose of this study is to determine whether Indomethacin Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00964431
- Testing
- Celecoxib 400 mg, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Dental Caries
Assessment of Caries Diagnosis and Caries Treatment in Dental PBRN Japan
The objective of this study is to examine what methods Dental PBRN Japan dentists adopt for diagnosis, treatment, and prevention of dental caries.
- Trial name
- NCT01680848
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Dental PBRN Japan
Dental Pulp Diseases, Dental Pulp Necrosis
Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Non-surgical root canal therapy (RCT) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection while preserving the tooth for the patient for mainly cosmetic purposes.
- Conditions
- Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
- Trial name
- NCT02698163
- Testing
- Nanodiamond reinforced Gutta Percha, Gutta Percha
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Los Angeles
Caries, Dental Pulp Exposure
Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Background: Dental caries is considered an oral health problem worldwide. In Chile the last national epidemiological study (2007) showed a national prevalence of dental caries in children 6 years (70.3%) and 12 (62.5%).
- Trial name
- NCT02492841
- Testing
- Mineral trioxide aggregate, Calcium hydroxide, Biodentine
- Where
- Chile
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Root Caries
Non-invasive Treatment of Root Caries in Older Adults
This study aims to test the effectiveness in reducing or arresting root caries lesion in community-dwelling elderly subjects by using high fluoridated toothpaste.
- Trial name
- MIT-RCTalca (NCT02647203)
- Testing
- Self-administered fluoridated dentifrices
- Where
- Chile
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- University of Talca
Class I Dental Restorations, Class II Dental Restorations
Clinical Evaluation of a New Dual-cure Universal Adhesive
The overall aim of this study is to evaluate the clinical performance and safety of the new dental dual-cure adhesive for luting indirect ceramic restorations (inlays and onlays).
- Conditions
- Class I Dental Restorations, Class II Dental Restorations, Insufficient Dental Restoration, Caries, Dental
- Trial name
- NCT06615544
- Testing
- Placement of indirect dental restoration
- Where
- Liechtenstein
- Volunteers
- 45 people
- Sponsor
- Ivoclar Vivadent AG
Children's Dental Anxiety
Reducing Children's Anxiety Using Homeopathic Remedy Before Dental Treatment
Pharmacological interventions to aid behavior management's techniques are commonly used in pediatric dentistry. The aim of the medicaments is to control behavior and allow safe completion of a dental procedure.
- Trial name
- NCT01658059
- Testing
- Homeopathic remedy
- Where
- Israel
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Autism Spectrum Disorder
Improving Dental Care and Oral Health in Children With Autism Spectrum Disorder
A randomized controlled trial (at sites) comparing the efficacy of the established AIR-P Dental Toolkit (control condition) to a combined regimen involving the Dental Toolkit and parent-mediated behavioral intervention…
- Trial name
- NCT03003221
- Testing
- AIR-P Dental Toolkit, Parent Training
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of California, Irvine
Dental Pain
Study of Buprenorphine HCl Buccal Film in the Treatment of Dental Pain
The purpose of this study is to assess the activity of buprenorphine hydrochloride (HCl) buccal film in the treatment of dental pain.
- Trial name
- NCT00941304
- Testing
- Oxycodone, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- BioDelivery Sciences International
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.