Clinical trials: Dentine Sensitivity
Dentin Sensitivity
Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity
Subjects will be enrolled into 3 balanced groups each using a different strength toothpaste. Dental hypersensitivity (DHS) will be assessed at study start, midway and study end.
- Trial name
- NCT04590040
- Testing
- 15% nano-HAP toothpaste, 5% KNO3 toothpaste
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dentine Hypersensitivity
Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity
The objective of the present study was to compare the effects of a commercially available dentifrice containing 2% strontium chloride and 5% potassium nitrate in a silica base, versus a control dentifrice, containing exactly the…
- Trial name
- NCT01426360
- Testing
- control dentifrice, strontium chloride/potassium nitrate dentifrice
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sun Yat-sen University
Dentin Sensitivity
Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream
This study will investigate the effectiveness of nanohydroxyapatite (nano-HAP)-containing toothpastes and cream to relieve dentin hypersensitivity, comparing it with those of a commercial desensitizing dentifrice containing…
- Trial name
- NCT02918617
- Testing
- Control toothpaste containing Novamin® technology, Control toothpaste containing 1500 ppm fluoride as MFP, Test toothpaste with nano-HAP (high concentration)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dentin Sensitivity
Effectiveness of Two Water-Based Potassium Oxalate Desensitizers
This study will compare the safety and effectiveness of two water-based potassium oxalate desensitizers on existing dentinal hypersensitivity.
- Trial name
- NCT02192307
- Testing
- Potassium oxalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dentin Sensitivity
A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Dentifrice in the Relief of Dentinal Hypersensitivity in a Chinese Population
The purpose of this study is to support long-term dentinal hypersensitivity (DH) relief claims of 0.454 percent (%) stannous fluoride (SnF2) containing toothpastes in China.
- Trial name
- NCT04950465
- Testing
- Sensodyne Sensitivity & Gum, Crest Cavity Protection Fresh Lime, Sensodyne Repair and Protect
- Where
- China
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentine Hypersensitivity
Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over a two week treatment period.
- Trial name
- NCT01592851
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
Effectiveness of Two Water-Based Potassium Oxalate Desensitizers on Dental Hypersensitivity
This study will compare the safety and effectiveness of two water-based potassium oxalate desensitizers on existing dentinal hypersensitivity.
- Trial name
- NCT02152826
- Testing
- Potassium oxalate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingival Recession
Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®
The purpose of the study is to evaluate whether clinical parameters for Puros Dermis are, at minimum, equivalent when compared to AlloDerm, the current industry standard, for the treatment of single, non-adjacent Miller's Class I…
- Trial name
- NCT00881959
- Testing
- Puros® Dermis versus Alloderm®
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Zimmer Biomet
Dentin Sensitivity
A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06354270
- Testing
- Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- HALEON
Dentin Sensitivity
Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity
This study will evaluate the effectiveness of an experimental dentifrice containing stannous fluoride, an established dentine tubule occlusion technology, at reducing dentine hypersensitivity (DH) compared to a negative control…
- Trial name
- NCT02861664
- Testing
- Stannous fluoride (SnF2), Sodium monofluorophosphate (SMFP)
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Clinical Study to Determine the Safety and Effectiveness of Dentinal Hypersensitivity Treatment With Two Different Toothbrushes
This study will determine the effects toothbrush type (power or manual) has on the safety and effectiveness of professional dentinal hypersensitivity treatment with a marketed oxalate-containing solution.
- Trial name
- NCT02513212
- Testing
- Potassium Oxalate, Stannous fluoride paste, Manual toothbrush
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dentin Sensitivity
A Study to Assess Efficacy of an Experimental Oral Rinse in Providing Long Term Relief From Dentinal Hypersensitivity
To investigate the efficacy of an experimental oral rinse, containing 1.5% potassium oxalate (KOX) and 0 parts per million (ppm) fluoride in relieving dentine hypersensitivity (DH) after 8 weeks use compared with a placebo oral…
- Trial name
- NCT03238352
- Testing
- Potassium oxalate, Sodium fluoride
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries, Salivary Function
Lesion Progression After Icon Treatment in Young Adults
This is a three year single site clinical evaluation of a FDA approved (510(k):K100062) lesion penetrating resin used to infiltrate and hamper progression of proximal carious lesions.
- Conditions
- Caries, Salivary Function, Tooth Sensitivity
- Trial name
- NCT01988337
- Testing
- Resin infiltration, Mock treatment
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dentin Sensitivity
A Real-World Evidence Study to Evaluate Oral Health Related Quality of Life Using an Anti-Sensitivity Toothpaste
The purpose of this study is to evaluate changes in oral health-related quality of life (OHrQoL) in participants suffering from Dentinal Hypersensitivity (DH) symptoms following the use of anti-sensitivity toothpaste for 24 weeks.
- Trial name
- NCT04964063
- Testing
- Potassium Nitrate + Sodium Fluoride
- Where
- United States
- Volunteers
- 655 people
- Sponsor
- HALEON
Dentin Hypersensitivity
A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity
The objective of this study is to evaluate the efficacy (changes in dentinal hypersensitivity) and safety (oral soft tissue evaluation) after use of one of four dentifrices in subjects with pre-existing hypersensitivity over an…
- Trial name
- NCT03965039
- Testing
- Dipotassium oxalate toothpaste, Stannous fluoride toothpaste, Potassium nitrate toothpaste
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dentin Hypersensitivity, Dentin Sensitivity
Cyanoacrylate and Laser and Dentin Sensitivity
This study aimed to evaluate the effectiveness of two treatments for dental hypersensitivity: cyanoacrylate (Super Bonder®) compared with use of low intensity laser treatment (LILT).
- Trial name
- Cyano-laser (NCT01111474)
- Testing
- Cyanoacrylate, Laser
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Dentin Hypersensitivity, Dentin Sensitivity
Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity
This exploratory study will characterize the efficacy profile of an experimental dual active 5 percent (%) potassium nitrate/0.454% stannous fluoride dentifrice, compared to a single active 0.454% stannous fluoride desensitizing…
- Trial name
- NCT03943095
- Testing
- Potassium Nitrate, Stannous Fluoride
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentine Sensitivity
Clinical Study to Evaluate the Efficacy of Two Dentifrices for Dentine Hypersensitivity
An 8 week clinical study to evaluate the ability of an experimental dentifrice containing calcium sodium phosphosilicate and sodium fluoride to provide relief from dentine hypersensitivity compared to a marketed dentifrice…
- Trial name
- NCT02371616
- Testing
- Calcium sodium phosphosilicate, Sodium fluoride, Sodium monofluorophosphate
- Where
- 3 sites in United Kingdom
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Bleaching, Tooth Sensitivity
Combined Bleaching Technique: Efficacy and Tooth Sensitivity
The aim of this clinical study is to evaluate the efficacy and dental sensitivity associated with Combined Bleaching Technique (in-office + at-home) varying in-office bleaching application under two different time protocols, and…
- Trial name
- NCT03089216
- Testing
- Combined Bleaching(2x20), Combined Bleaching(2x20) with arginine, Combined Bleaching (1x20)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Terezinha de Jesus Esteves Barata
Dentin Sensitivity
The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)
This single center study will investigate the efficacy of an experimental stannous fluoride containing dentifrice in relieving DH compared with a standard fluoride dentifrice after short term use.
- Trial name
- NCT02924350
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- United Kingdom
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline