Clinical trials: Dependence
Opioid-Dependence Among Adolescents
Science-Based Treatment for Opioid-Dependent Adolescents
The purpose of this study is to evaluate ways to optimize outcomes from combined behavioral-pharmacological treatment for opioid-dependent youth.
- Trial name
- NCT00182572
- Testing
- buprenorphine, naltrexone, behavior therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Development and Research Institutes, Inc.
Cocaine Dependence
A Multi-Center Trial of Nepicastat for Cocaine Dependence
The objective of this study is to evaluate the safety and efficacy of Nepicastat in improving the number of subjects that achieve abstinence from cocaine and reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT01704196
- Testing
- Nepicastat
- Where
- 10 sites in United States
- Volunteers
- 179 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Adults with affective disorders are at increased risk for smoking, nicotine dependence, and using high nicotine yield…
- Trial name
- NCT02232737
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Dependence
Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after single-dose of nicotine.
- Trial name
- NCT01084603
- Testing
- Oral Nicotine, NiQuitinTM Nicotine Lozenge, Nicorette® Nicotine Gum
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- McNeil AB
Tobacco Dependence
Effects of Naltrexone on Nicotine Reinforcement
Despite preclinical evidence supporting the role of the endogenous opioid system in the reinforcing effects of nicotine, the efficacy of the opioid antagonist naltrexone (NTX) as a tobacco dependence treatment remains unresolved.
- Trial name
- NCT00270231
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Caffeine Dependence, Anxiety
Remote Guided Caffeine Reduction
The purpose of this online research study is to determine whether or not a gradual caffeine reduction program developed at Johns Hopkins can help people reduce their caffeine use.
- Conditions
- Caffeine Dependence, Anxiety, Sleep Disturbance, Gastrointestinal Dysfunction
- Trial name
- NCT04560595
- Testing
- Caffeine Reduction Manual
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5
The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers
- Trial name
- NCT00000330
- Testing
- Opioid-Related Disorders
- Where
- United States
- Sponsor
- University of Colorado, Denver
Visual Dependence, Multisensory
Visual Dependence and Multisensory Balance Exercise
The study aimed to investigate the effectiveness of multisensory balance training on the levels of visual dependence and sensory organization capacity in community-dwelling older adults.
- Conditions
- Visual Dependence, Multisensory, Exercise, Training
- Trial name
- NCT04213521
- Testing
- Multisensory balance exercise, Conventional balance exercise
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Quality Indicators, Physical Disability
Impact of Educational and Professional Supportive Interventions on Nursing Home Quality Indicators
Introduction: Efficacy of audit and feedback interventions on nursing home (NH)quality indicators is not well-established. The main objective: The main purpose of the IQUARE study was to examine the impact of two types of audit…
- Trial name
- IQUARE (NCT01703689)
- Testing
- Audit and Feedback, Cooperative Work
- Where
- 175 sites in France
- Volunteers
- 8,039 people
- Sponsor
- Agence Régionale de la Santé - Midi Pyrénées
Alcohol Dependence
Research on Individualized Treatment for Alcoholism
The purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (Broad Spectrum Treatment and Motivational Enhancement Treatment) combined with 3 or 6 months of treatment…
- Trial name
- RITA (NCT00523133)
- Testing
- naltrexone, Broad Spectrum Treatment, Motivational Enhancement Treatment
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Indiana University
Cocaine Dependence
Clavulanic Acid for the Treatment of Cocaine Use Disorder
A dose escalation study to assess the efficacy and safety of Clavulanic Acid (CLAV) vs. placebo (PBO) for the treatment of cocaine use disorder (CUD)
- Trial name
- NCT05562349
- Testing
- Clavulanic Acid Only Product
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Temple University
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
This treatment intervention trial is designed for men and women with substance dependence and comorbid Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01365247
- Testing
- Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure, Relapse Prevention Treatment, Active Monitoring Control Group
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- The City College of New York
Alcohol Dependence, Alcohol Use Disorders
Mifepristone Treatment of Alcohol Use Disorder
This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up…
- Conditions
- Alcohol Dependence, Alcohol Use Disorders, Alcohol Abuse, Alcoholism
- Trial name
- NCT02179749
- Testing
- Mifepristone 1200 mg daily, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Scripps Research Institute
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment 1 - 1
The purpose of this study is to assess the clinical efficacy of the buprenorphine/naloxone combination tablet for alternate-day dosing and determine whether multiples of the daily dose are necessary to maintain an effective…
- Trial name
- NCT00000326
- Testing
- Heroin Dependence
- Where
- United States
- Sponsor
- University of Colorado, Denver
Drug Dependence
Automatic Versus Evaluative Components of Cue Reactivity
Background: Relapse to drug abuse often happens in the presence of stimuli that are associated with previous drug use, also known as cues. Drug-taking behavior appears to be partly controlled by such cues.
- Trial name
- NCT01036126
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Marijuana Abuse, Mood Disorders
Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1
This study will assess the effectiveness of a combination of buspirone and motivational interviewing therapy in the treatment of marijuana dependence.
- Trial name
- NCT00149617
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal
The proposed research is a longitudinal human lab study to examine how measures of abuse liability and product appeal vary by e-cigarette device type, and how these lab assessments may predict subsequent e-cigarette and other…
- Trial name
- NCT02520349
- Testing
- MarkTen and e-Go e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Truth Initiative
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Addiction
Primary Dependence to Analgesic Drugs
Abuse of analgesics represents an important part of prescription drug abuse. The consequences in terms of morbidity and mortality at the population level could reach worryingly high levels, as illustrated by the US context.
- Trial name
- NEO-ADDICT (NCT03684317)
- Where
- France
- Sponsor
- University Hospital, Toulouse
Alcoholism
Study of the Medication Prazosin for Alcohol Dependence
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
- Trial name
- NCT00762710
- Testing
- Prazosin medication
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
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