Clinical trials: Dependence
Nicotine Dependence, Alcohol Use Disorder
Combining Varenicline and Naltrexone for Smoking Cessation
This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for…
- Trial name
- NCT02698215
- Testing
- Varenicline, Varenicline plus Naltrexone
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Tobacco Dependence
Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after multiple-doses of nicotine.
- Trial name
- NCT01084707
- Testing
- Oral Nicotine, Nicotine Lozenge, Nicotine gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Tobacco Dependence
Tobacco Dependence Treatment for Asian Americans
Nicotine dependence is very common among Asian Americans; yet, research on understanding and treating nicotine dependence in this group is almost nonexistent.
- Trial name
- NCT01091363
- Testing
- Standard, Deep Cultural
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Drug Dependence
Enhancing the Role of Commune Health Workers in HIV and Drug Control: A Randomized Controlled Trial
This proposed study is an initiative for HIV prevention and care that integrates intervention efforts at multiple strata: Community Health Workers (CHWs), Injecting Drug Users (IDUs), and their Family Members (FMs).
- Trial name
- NCT02130921
- Testing
- Intervention to Address Drug Use and HIV in Vietnam
- Where
- 2 sites in Vietnam
- Volunteers
- 1,800 people
- Sponsor
- University of California, Los Angeles
Opioid Dependence, Heroin Dependence
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)
The purpose of this study, SALOME, is to determine if 1) the closely supervised provision of injectable, hydromorphone (HDM; trade name Dilaudid™) is as effective as injectable diacetylmorphine (DAM; heroin) in the treatment of…
- Trial name
- SALOME (NCT01447212)
- Testing
- Hydromorphone, Injectable, Diacetylmorphine, injectable, Hydromorphone, liquid oral
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of British Columbia
Nicotine Dependence, Cigarettes
Penn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay Quit
This study aims to pilot a method of collecting the post-discharge follow-up data required by the Joint Commission Tobacco Measure Set, using text messages sent to and received from patients' cellular-telephones.
- Trial name
- NCT02986711
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Opioid Dependence, Methadone Withdrawal Syndrome
Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients
The primary objective of this study is to assess QTc (an interval of the heart rhythm) interaction effects between lofexidine and methadone.
- Trial name
- NCT01558934
- Testing
- Lofexidine HCl
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Adult Opioid-Dependence
Applying Web Technology to Buprenorphine Treatment
The purpose of this clinical trial is to examine the efficacy and cost-effectiveness of an interactive, computer-based psychoeducational system when used by opioid-dependent patients in office-based buprenorphine treatment.
- Trial name
- NCT00182598
- Testing
- computer-based psychoeducational intervention, community-based substance abuse counseling
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Development and Research Institutes, Inc.
Cannabis Dependence, Healthy
The Neural Correlates of Cannabis Use
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and…
- Trial name
- Multimodal (NCT03104257)
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Yale University
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Methylphenidate Treatment for Cocaine Abuse and ADHD - 1
Many cocaine dependent individuals are also diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methylphenidate (Ritalin) is currently approved to treat individuals diagnosed with ADHD.
- Trial name
- NCT00136734
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Effect of Oxytocin on Craving and Therapy Response
The purpose of this study is to examine the impact of a medication called oxytocin on marijuana use and therapy response in people who frequently use marijuana.
- Trial name
- NCT01827332
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Validation of a Remote Wireless Sensor Network (WSN) Approach to the Individualized Detection of Cocaine Use in Humans
This study looks to explore the feasibility, sensitivity, validity, and specificity of a Remote Wireless Sensor Network (RWSN) approach to the detection of cocaine use/intoxication in the inpatient human laboratory, as well as in…
- Trial name
- NCT02018263
- Testing
- Cocaine hydrochloride, Exercise, Nicotine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Opioid Abuse, Opioid Dependence
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers
Opioid drugs increase glial cell activation which may be related to the abuse liability of opioid drugs. Data supporting this hypothesis have demonstrated that glial cell attenuators decrease the positive rewarding aspect of…
- Trial name
- NCT01740414
- Testing
- MN-166 (50 mg) First
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Incubation of Alcohol Craving During Abstinence
In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism.
- Trial name
- NCT01991704
- Volunteers
- 99 people
- Sponsor
- National Institute on Drug Dependence, China
Nicotine Dependence, Thoracic Diseases
Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study
Globally, approximately 230 million adults undergo surgical procedures each year, with around 30% of patients maintaining smoking habits prior to surgery.
- Conditions
- Nicotine Dependence, Thoracic Diseases, Analgesia
- Trial name
- NCT07250230
- Testing
- Nicotine patch
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Provincial People's Hospital
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Opiate Dependence
Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia
The long-term goals of this study are to foster development and dissemination of evidence-based behavioral and pharmacological treatments to reduce HIV transmission, injection drug use (IDU), and heroin use in Russia.
- Trial name
- NCT01389167
- Testing
- Vivitrol, Naltrexone (oral), BDRC
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Yale University
Opiate Dependence
HIV Risk Reduction and Drug Abuse Treatment in Malaysia
A randomized clinical trial comparing drug abuse and HIV risk reduction counseling (DC-HIV) alone, DC-HIV combined with naltrexone maintenance, and DC-HIV combined with buprenorphine maintenance for the treatment of heroin…
- Trial name
- NCT00383045
- Testing
- Buprenorphine/Subutex, Naltrexone, Drug counseling
- Where
- 2 sites in United States, Malaysia
- Volunteers
- 180 people
- Sponsor
- Yale University
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