Clinical trials: Dependence
Cannabis Dependence, Alcohol Dependence
Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence
The primary aim of the supplemental study is to provide POC testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence.
- Conditions
- Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
- Trial name
- NCT02210195
- Testing
- aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Scripps Research Institute
Cocaine Dependence
Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.
This proposal describes a combined laboratory and clinical trial preliminary investigation to advance medication development for cocaine dependence.
- Trial name
- NCT02255357
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Use Disorder
Psilocybin-assisted Treatment for Cannabis Use Disorder
This pilot study will evaluate the therapeutic potential of psilocybin in people with Cannabis Use Disorder (CUD). This study will examine the impact of psilocybin treatment on cannabis use and related variables in 12 people with…
- Trial name
- NCT06660381
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder, Dual Tobacco Use
Addictive Potential of LCCs in Dual Users
This study is about whether or not little cigars and cigarillos cause or maintain addiction, and if flavors, such as fruit, make them more addictive.
- Conditions
- Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking
- Trial name
- NCT03496077
- Testing
- Flavored and unflavored little cigars/cigarillos (LCCs)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- UConn Health
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-deficit Hyperactivity Disorder (ADHD)
Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this medication may decrease drug use in individuals dependent on cocaine.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00514202
- Testing
- Dextroamphetamine SR
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center, Houston
Depressive Disorder, Major Depressive Disorder
Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence
This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Dysthymic Disorder, Alcohol-Related Disorders
- Trial name
- NCT01528748
- Testing
- Cognitive Behavioral Analysis System of Psychotherapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Virginia
Opioid Use Disorder, Opioid Dependence
Measuring Acute Drug Demand in Humans
This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.
- Trial name
- NCT05829655
- Testing
- Drug A (Blinded Drug), Drug B (Blinded Drug), Drug C (Blinded Drug)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Nicotine Dependence, Smoking
Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among…
- Conditions
- Nicotine Dependence, Smoking, Tobacco Use Disorder, Nicotine Use Disorder
- Trial name
- NCT00429208
- Testing
- Nicotine
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Parkinson Disease, Freezing of Gait
Understand FoG in PD: Behavioral Physiology and Clinical Application
The overall goals of this proposed study are to investigate the behavioral and neurophysiological mechanisms of patients with Parkinson's disease (PD) experiencing freezing of gait (FoG).
- Trial name
- NCT02987140
- Testing
- Clinical evaluations
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Complex and Chronic Pluripathology
Case Management of Complex Pluripathology in Primary Care
Aims To assess the effect of the implementation of the Community Nurse Case Manager (CNCM) in the care of complex and pluripathological chronic patients (CPCP) with dependence, from Primary Care, on functional capacity, cognitive…
- Trial name
- ENGESCC (NCT06155591)
- Testing
- Community Nurse Case Manager (CNCM)
- Volunteers
- 212 people
- Sponsor
- José Ignacio Recio Rodriguez
Smoking, Tobacco Use
Testing Counseling Styles to Motivate Smokers to Quit
The purpose of this study is to determine, among a sample of general adult smokers, the effectiveness of three different counseling interventions for motivating quit attempts among smokers not yet ready to quit.
- Conditions
- Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT01188018
- Testing
- Brief Advice (BA), Motivational Interviewing (MI), Health Education (HE)
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Heroin Dependence
Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts
The study assessed the efficacy of a methadone-induced memory retrieval-extinction procedure on heroin craving and relapse. Male participants aged 18-55 years old and prescribed MMT to treat heroin dependence were included in the…
- Trial name
- NCT04133974
- Testing
- methadone induced memory retrieval-extinction procedure
- Volunteers
- 87 people
- Sponsor
- National Institute on Drug Dependence, China
Alcoholism, Alcohol-Related Disorders
A Novel Compound for Alcoholism Treatment
Background: Hormones are naturally occurring chemicals in your body. Ghrelin is a hormone that is mainly produced by the stomach and stimulates appetite. Some studies suggest it may stimulate alcohol craving and use.
- Conditions
- Alcoholism, Alcohol-Related Disorders, Alcohol Dependence, Alcohol Drinking Related Problems
- Trial name
- NCT02039349
- Testing
- PF-05190457
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid Use, Opioid Use Disorder
Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate.
This study will aim to investigate the gut microbiota in Egyptian patients with opioid use disorders and correlate microbiota bacterial abundance with clinical data.
- Conditions
- Opioid Use, Opioid Use Disorder, Opioid Dependence
- Trial name
- NCT06231849
- Testing
- stool analysis
- Volunteers
- 52 people
- Sponsor
- Assiut University
Alcohol-Related Disorders, Marijuana Abuse
Substance Dependent Teens - Impact of Treating Depression Study 1 - 1
The purpose of this study is to evaluate the impact of treating depression on substance dependent teens.
- Conditions
- Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
- Trial name
- NCT00061113
- Testing
- Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Cessation, Tobacco Use Disorder
Treating Tobacco Dependence in Adolescents With Co-occurring Psychiatric Disorders
This research aims to identify efficacious strategies for treating tobacco dependence among adolescent smokers with co-occurring psychiatric disorders.
- Trial name
- NCT00618943
- Testing
- Tobacco Use Cessation
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Post-traumatic Stress Disorder, Alcohol Dependence
Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
Method: This study is designed as an accompaniment to an already funded study - a 12-week treatment trial with prazosin for patients with PTSD and AD. The study design will consist of III phases.
- Trial name
- NCT00923923
- Testing
- stress
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Yale University
Alcohol Use Disorder, Alcohol Abuse/Dependence
Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), approved for the treatment of type 2 diabetes and obesity, have shown promise as a novel treatment for alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcohol Abuse/Dependence, Alcohol Dependence, Alcoholism
- Trial name
- DUALPSYCHIATRY (NCT06939088)
- Testing
- Tirzepatide
- Where
- 2 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
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