Clinical trials: Dependence
Cannabis Use Disorder
Cannabidiol: a Novel Intervention for Cannabis Use Problems?
The purpose of this trial is to investigate a novel treatment for cannabis dependence: cannabidiol. Between 96 and 168 young people who want to quit cannabis and meet criteria for moderate cannabis use disorder (DSM-5) will be…
- Trial name
- NCT02044809
- Testing
- Cannabidiol
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Methamphetamine Dependence
Open-Label Disulfiram for Methamphetamine Dependence
This 8 week, open-label pilot clinical trial will examine the safety and tolerability of disulfiram at 250 mg/day in up to fifteen methamphetamine dependent individuals.
- Trial name
- NCT00731133
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arkansas
Cocaine Addiction, Cocaine Dependence
Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction
-Context: Study objectives Primary: impact of modafinil versus placebo on DAT density modifications in the striatal and extra-striatal regions in cocaine dependent subjects hospitalised from D3 to D21.
- Trial name
- CAIMAN (NCT00701532)
- Testing
- Modafinil and PET (brain imaging)
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
HIV Infections, Drug Abuse
Disulfiram Interactions With HIV Medications: Clinical Implications
The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease.
- Trial name
- NCT00878306
- Testing
- Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stimulant Abuse and Dependence
Exercise as a Treatment for Substance Use Disorders Protocol
The purpose of this study is to investigate if health interventions (intensive exercise or health education) can be used to help improve substance abuse treatment.
- Trial name
- STRIDE (NCT01141608)
- Testing
- Vigorous Intensity High Dose Exercise, Health Education Intervention
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine-Related Disorders
Effects of Phenytoin on Cocaine Use in Humans - 2
The purpose of this study is to determine the effects of phenytoin on the self-administration of smoked cocaine.
- Trial name
- NCT00000285
- Testing
- Phenytoin
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Abuse, Nicotine Dependence
Cognitive Task Development and Implementation for Functional MRI Studies
Background: Drugs of abuse have effects on mood, behavior, thinking, and decision making that may encourage people to continue using them and make it difficult for them to stop.
- Trial name
- NCT01036685
- Where
- United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
PPPD
Identification of Visual Dependence in PPPD Patients With the Aid of Virtual Reality.
The aim of this study is to evaluate whether increased visual dependence can be identified with the help of Virtual Reality (VR).
- Trial name
- OKAN (NCT06017908)
- Testing
- Optokinetic stimulation through Virtual Reality
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Obesity, Alcohol Dependence
Norepinephrine Transporter Imaging in Addiction Disorders
In this study we propose to study 24 unmedicated abstinent alcohol dependent patients, 24 obese individuals and 24 individually matched healthy control subjects and determine Norepinephrine Transporter (NET) expression in vivo…
- Trial name
- NCT01719458
- Testing
- (S,S)-[11C]MRB
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
This study will investigate a treatment strategy in which a computer-assisted behavioral intervention will be used to help individuals stop their use of cocaine.
- Trial name
- NCT01986075
- Testing
- Computer-assisted behavior therapy, Mixed-Amphetamine Salts- Extended Release (MAS-ER)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Abuse, Cannabis Dependence
Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms
Background: Marijuana is the most widely used illicit drug in the world, yet relatively little is known about users who try to quit without formal treatment ( spontaneous quitting).
- Trial name
- NCT01603992
- Where
- 3 sites in United States
- Volunteers
- 822 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Vaping
Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents
Social media based intervention to support teens in their efforts to quit vaping.
- Trial name
- NCT04707911
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Liver Disease
Efficacy of Baclofen Vs Naltrexon in Achieving & Maintaining Abstinence in Alcohol Dependence.
ALD is the most common cause of liver cirrhosis in western world. In patients with ALD persistent alcohol intake is associated with increased mortality while cessation of alcohol consumption improve survival.
- Trial name
- NCT06175507
- Testing
- Naltrexon, Baclofen
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Schizophrenia, Drug Abuse/Dependency
Influence of Nicotine on Cognitive Function in Schizophrenic Patients With and Without Comorbid Drug Dependence
Background: Individuals with schizophrenia have a significantly higher tendency to develop substance abuse or dependence than the general population.
- Trial name
- NCT01037075
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Selegiline in Outpatient Treatment for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and clinical safety of selegiline in the treatment of cocaine dependence and to assess neurotoxicity (Magnetic Resonance Imaging, MRI) post-hoc as a possible variable for…
- Trial name
- NCT00000336
- Testing
- Selegiline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy
Dose-dependent Kinetics of Thiamin in Healthy Volunteers With and Without Functional OCT1 Hepatic Transporters
This study investigates the differences in thiamin (vitamin B1) kinetic parameters in two cohorts of healthy volunteers: Cohort 1) OCT1 wild type genotypes n = 12 Cohort 2) OCT1 deficient genotypes n = 12 Participants will be…
- Trial name
- THIAMO-1 (NCT06122701)
- Testing
- Thiamin p.o., Thiamin i.v.
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Marijuana Dependence
Marijuana Treatment Project 4
Marijuana is the most commonly used illicit drug in the US, but treatment for marijuana dependence is not fully effective. In the current proposal we are exploring the idea that more tailored teaching of coping skills may result…
- Trial name
- MTP4 (NCT02030665)
- Testing
- Contingency Management, Individualized Assessment & Treatment, Cognitive-Behavioral Treatment
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- UConn Health
Tobacco Cessation
Impact of an Intervention of Screening, Treatment Initiation and Referral to PROmote Smoking CEssation in Emergency Department Patients
Smoking cessation assistance is one of the major issues in prevention policies because the prevalence of smoking remains high in France.
- Trial name
- PROSCEED (NCT05552534)
- Testing
- STIR PROTOCOL
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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