Clinical trials: Deprescribing, active
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Geriatric Patients
Attitudes and Beliefs Related to Benzodiazepine Deprescribing
The use of benzodiazepines in older adults is associated with an increased risk of adverse effects due to age-related physiological changes.
- Trial name
- BENZ-AC (NCT07474532)
- Testing
- Patient rPATD Benzo questionnaire, Geriatrician rPATD Benzo questionnaire
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Proton Pump Inhibitors, Deprescribing
RAK-PRIDE: Optimizing Proton Pump Inhibitor Use Through Education and Intervention
The goal of this study is to determine if a pharmacist-led educational intervention can reduce the inappropriate use of proton pump inhibitors (PPIs) among adult patients (≥18 years) with potentially inappropriate PPI…
- Conditions
- Proton Pump Inhibitors, Deprescribing, Inappropriate Use
- Trial name
- NCT06858384
- Testing
- Control (Standard treatment), Pharmacist-Led Educational Intervention
- Where
- United Arab Emirates
- Volunteers
- 479 people
- Sponsor
- RAK Medical and Health Sciences University
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Respiratory Tract Diseases
Impact of Pharmacist Led Multidisciplinary Deprescribing Strategy in Patients With Respiratory Tract Infections
This prospective, open-label, randomized controlled trial will evaluate the impact of a pharmacist-led multidisciplinary deprescribing strategy on azithromycin use in clinically stable adults aged 18-65 years with respiratory…
- Trial name
- RCT (NCT07849491)
- Testing
- Pharmacist-Led Azithromycin Deprescribing Intervention
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Xi'an Jiaotong University
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Palliative Care, Cancer
Attitudes Towards Deprescribing Medications in Cancer Patients and Impact of Educational Intervention by a Clinical Pharmacist
Participation in this study consists in responding to some questions from two questionnaires in Romanian about how participants feel about deprescribing, participants' treatment and how participants understand medical…
- Trial name
- NCT06771999
- Testing
- Educational intervention by a clinical pharmacist
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Heartburn, Dyspepsia
Primary carE PPi dEprescRibing Trial
Proton pump inibitors (PPIs) is a class of medications that reduce the acid secretion in the stomach. These medications are very effective to relieve symptoms of acid reflux for a well-identified group of diseases and conditions.
- Conditions
- Heartburn, Dyspepsia, Reflux
- Trial name
- PEPPER (NCT05629143)
- Testing
- de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate
- Where
- Belgium
- Volunteers
- 724 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Deprescribing, Antidepressant
General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients
In Belgium, many adults who have suffered from depression keep using antidepressants on a daily basis for years afterwards, sometimes longer than guidelines recommend.
- Conditions
- Deprescribing, Antidepressant, Depression Disorder, Discontinuation
- Trial name
- GPS-AD (NCT07398053)
- Testing
- GPS-AD intervention
- Volunteers
- 324 people
- Sponsor
- University Ghent
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Rheumatic Diseases, Inflammatory Arthritis
The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate…
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis
- Trial name
- NCT07278609
- Testing
- MedSafer deprescribing opportunity reports, EMPOWER brochures
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making
Factors Determining the Rate of Adoption of Pharmaceutical Recommendations by Patients in Primary Care Following a Medication Review by a Pharmacist
Polypharmacy is a growing public health concern associated with adverse drug events, drug interactions, and hospitalizations. Medication reviews (MedRev) are structured evaluations of patients' medications aiming to optimize…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making, Medication Review
- Trial name
- REVMedAdopt (NCT07606716)
- Testing
- medication review and deprescribing
- Where
- Belgium
- Volunteers
- 123 people
- Sponsor
- Université Catholique de Louvain
Hypothyroidism
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or…
- Trial name
- NCT06629272
- Testing
- D-THIO (Deprescribing Thyroid Hormone In Older Adults), Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Overactive Bladder, Deprescribing
Deprescribing dRrugs for Overactive Bladder in General Practice (DROP)
The objective is to understand and evaluate the effectiveness of a deprescribing intervention in primary care, specifically targeting medications for overactive bladder in individuals aged 65 or older.
- Conditions
- Overactive Bladder, Deprescribing, PIMS
- Trial name
- DROP (NCT06110975)
- Testing
- deprescribing-intervention
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Anne Estrup Olesen
Medication Adverse Effects, Older Adults (65 Years and Older)
Population Health Approach to Optimizing Medications in Older Adults
This randomized controlled pragmatic pilot study examines the feasibility and acceptability of a population health-based deprescribing intervention that leverages a polypharmacy risk prediction model.
- Conditions
- Medication Adverse Effects, Older Adults (65 Years and Older), Polypharmacy, Polypharmacy Patients
- Trial name
- POP-MED (NCT06110156)
- Testing
- Patient-tailored deprescribing assessment and intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Medication Overuse, Deprescriptions
Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events.
- Conditions
- Medication Overuse, Deprescriptions, Polypharmacy, Frailty Syndrome
- Trial name
- NCT06470308
- Testing
- Medication Reviews and Deprescribing
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Crete
Chronic Obstructive Pulmonary Disease (COPD)
Improving Medication Management in COPD
A pilot trial to examine feasibility of a pharmacist-led intervention for patients with COPD (Chronic Obstructive Pulmonary Disease) and multimorbidity to improve medication safety and reduce dyspnea.
- Trial name
- NCT07453719
- Testing
- Pharmacist-led Medication Management Intervention
- Volunteers
- 92 people
- Sponsor
- Duke University
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Cancer
STATIC - Statin Termination in Cancer
There are many guidelines on when to start drug treatment, but surprisingly few guidelines on how and when to stop drugs. For example, there are currently no clear guidelines on when to stop preventive medications such as statins…
- Trial name
- STATIC (NCT07543432)
- Testing
- Deprescribing statins
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Stiftelsen Stockholms Sjukhem