Clinical trials: Deprescription
Schizophrenia, Schizoaffective Disorder
Anticholinergic Deprescription in Schizophrenia
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with…
- Trial name
- NCT06562608
- Testing
- Anticholinergic Deprescription, No Anticholinergic Deprescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Deepak K. Sarpal, M.D.
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Deprescriptions, Polypharmacy
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
Overuse is common in frail older people with polypharmacy, especially in frail older users of multidose drug dispensing (MDD) systems.
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- NCT05609981
- Testing
- Clinical medication review focused on deprescribing
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- SIR Institute for Pharmacy Practice and Policy
Dementia, Deprescriptions
Optimization of Deprescribing Antidepressants in Nursing Home Residents With Dementia
The effectiveness of psychotropic medication on behavioral and psychological symptoms in dementia (BPDS) is limited, while they are associated with a higher risk of morbidity and mortality.
- Conditions
- Dementia, Deprescriptions, Antidepressive Agents, BPSD
- Trial name
- NCT04985305
- Testing
- Teaching material, Pre-visit reflection tool, Dialogue tool
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Medication Overuse, Deprescriptions
Prescribing Outcomes of a GP-Targeted Deprescribing Educational Intervention: A Cluster Randomized Trial
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events.
- Conditions
- Medication Overuse, Deprescriptions, Polypharmacy, Frailty Syndrome
- Trial name
- NCT06470308
- Testing
- Medication Reviews and Deprescribing
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Crete
Fall, Congestive Heart Failure
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Polypharmacy is common among older adults in the United States and is associated with harms such as adverse drug reactions and higher costs of care.
- Conditions
- Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
- Trial name
- NCT03791580
- Testing
- Commitment nudge, Justification nudge
- Where
- United States
- Sponsor
- RAND
Polypharmacy, Deprescription
Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults
Potentially inappropriate medications (PIMs) can lead to adverse drug events (ADEs) among older adults and especially those classified as frail. ADEs are responsible for nearly 27,000 hospital admissions in Canada annually.
- Conditions
- Polypharmacy, Deprescription, Aged
- Trial name
- MedSafer (NCT02918058)
- Testing
- MedSafer
- Where
- Canada
- Volunteers
- 924 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polypharmacy, Deprescriptions
Deprescribing: a Portrait and Out-comes of the Reduction of Polypharmacy in Portugal
This study protocol comprises three phases. The first two phases will be nationwide and aim to evaluate the prevalence and patterns of polypharmacy and assess the barriers and facilitators of deprescribing perceived by older…
- Trial name
- DePil17-20 (NCT03283735)
- Testing
- Elderly Enablement
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Polypharmacy, Gabapentin
Deprescription of Gabapentinoids in Medical Inpatients
In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care…
- Conditions
- Polypharmacy, Gabapentin, Pregabalin
- Trial name
- GABA-WHY (NCT04855578)
- Testing
- In-Hopsital Patient Educational Brochure, Physician Education about Gabapentinoid Prescription
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Aging, Fall Injury
Medication Empowerment and Deprescription for Safety (MEDS) Study
The long-term goal of this pragmatic, cluster randomized study is to develop a sustainable program for healthcare systems to reduce fatal and nonfatal falls among high-risk older adults living independently in their communities.
- Trial name
- MEDS (NCT04612166)
- Testing
- Medication Action Plan and Patient Empowerment (MAP-PE )
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Iowa
Proton Pump Inhibitors, Deprescription
Efficacy of a Multi-faceted Intervention to Deprescribe Proton Pump Inhibitors (PPI) in Primary Care: a Population-based, Pragmatic, Cluster-randomized Controlled Trial.
Deprescribing is defined as "the process of withdrawal of an inappropriate medication, supervised by a health care professional with the goal of managing the polypharmacy and improving outcomes".
- Trial name
- DeprescrIPP (NCT04255823)
- Testing
- General practitioner and Patient receive informations related to PPI deprescribing., Only General practitioner receive informations related to PPI deprescribing.
- Where
- France
- Volunteers
- 34,000 people
- Sponsor
- Nantes University Hospital
Deprescriptions, Aged
Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults
The goal of this randomized controlled trial is to assess the effectiveness of a pharmacist-led medication review using the locally developed Malaysian Potentially Inappropriate Prescribing Screening tool in Older Adults…
- Conditions
- Deprescriptions, Aged, Inappropriate Prescribing, Potentially Inappropriate Medications
- Trial name
- NCT05875623
- Testing
- MALPIP criteria
- Where
- Malaysia
- Volunteers
- 500 people
- Sponsor
- Monash University
Deprescriptions, Polypharmacy
Effects of Communication Training to Involve Older People in Decisions to DEPRESCRIBE Cardiometabolic Medication: a Cluster-randomized Trial in Primary Care
The researchers will investigate the effects of a communication training for community pharmacists and general physicians that aims to make it easier for them to stop or lower medication for cardiovascular disease and/or diabetes…
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- CO-DEPRESCRIBE (NCT05507177)
- Testing
- communication training programme for healthcare providers
- Where
- Netherlands
- Volunteers
- 310 people
- Sponsor
- University Medical Center Groningen
Schizophenia Disorder, Schizoaffective Disorder
Reduction of Anticholinergic Medications Among Persons With Schizophrenia or Other Psychiatric Disorders
The goal of this study is to reduce Anticholinergic Medication (ACM) in persons with psychoses or serious mental illness, when these medications are no longer needed.
- Conditions
- Schizophenia Disorder, Schizoaffective Disorder, Bipolar Disorder, Psychiatric Disorders
- Trial name
- RAMP (NCT07043803)
- Testing
- Reduction of anticholinergic medication
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Pittsburgh